Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
HCCA2 (hepatocellular carcinoma-associated gene 2) was initially identified as a
HCC
(hepatocellular carcinoma)-specific protein and subsequently, a long splice variant of HCCA2 was identified as a co-activator of transcription factor YY1 (Yin Yang 1). To investigate the role of HCCA2 in
HCC
genesis and progression, we screened a human fetal liver cDNA library and identified a novel HCCA2-interacting protein,
MAD2L2
(
MAD2 mitotic arrest deficient-like 2 (yeast)
). The interaction between HCCA2 and
MAD2L2
was confirmed by in vitro and in vivo binding assays and the interaction domain was mapped to the N-terminus of HCCA2 by sequential deletion. HCCA2 and
MAD2L2
also colocalized in the nucleus of Hela cells. Furthermore, overexpression of HCCA2 led to cell cycle arrest at G0/G1 phase and therefore inhibited cell proliferation. Our research suggests that HCCA2 may play a novel role in cell cycle regulation.
...
PMID:Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. 1754 14
