Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated whether hepatocyte growth factor (HGF) enhances the invasion activity of three human
HCC
cell lines, HLF, HLE, and HC-4, in vitro. The analysis of the invasiveness consisted of the production of
u-PA
and the chemotaxis for fibronectin. Invasion activity of all cell lines was enhanced by the addition of recombinant human hepatocyte growth factor (rhHGF) to the medium. HGF stimulated the production of
u-PA
in HLF cells. HGF accelerated the chemotaxis of HC-4 and HLE. These data suggest that HGF increase the invasion activity of human
HCC
cell lines by affecting the production of
u-PA
or the chemotaxis for fibronectin.
...
PMID:Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines. 947 7
