Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Our previous study identified RhoC as an invasion and metastasis marker in hepatocellular carcinoma patients. Recent document suggested RhoGTPase is required for autocrine motility factor signaling. In this study, we questioned whether there is a correlation between expression of
autocrine motility factor receptor
and RhoC. Furthermore, we questioned whether elevated expression of autocrine motility factor correlates with metastasis and poor prognosis of
HCC
. The mRNA expression level of
AMFR
and RhoC were examined by RT-PCR in 25 cases of
HCC
and pericarcinomatous liver tissues (PCLT). In addition, the correlation between the expression level of
AMFR
and clinical pathologic parameters was analyzed. Furthermore, follow-up information was collected to evaluate the prognostic value of
AMFR
for
HCC
patients. Our results showed that the expression of
AMFR
and RhoC significantly increased in
HCC
compared with PCLT; extrahepatic metastatic lesions expressed significantly higher levels of
AMFR
and RhoC than corresponding intrahepatic
HCC
tissues. There is a highly significant correlation of
AMFR
expression levels with tumor vein invasion, number of tumor nodes, and tumor stage. Anticipatively, positive correlation was observed between mRNA expression of
AMFR
and RhoC gene. Furthermore, the
HCC
patients with high-expression of
AMFR
had significant high recurrence/metastasis and shorter survival than those with low-expression of
AMFR
. Together, our findings suggested a strong correlation between the expression of
AMFR
and RhoC and also a correlation between overexpression of them and invasion and metastasis of
HCC
. Furthermore, our data indicated
AMFR
as a potential prognosis for
HCC
.
...
PMID:Elevated expression of autocrine motility factor receptor correlates with overexpression of RhoC and indicates poor prognosis in hepatocellular carcinoma. 1726 25
