Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1864663 (
HCC
)
2,985
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Related research has recognized the vital role of methionine cycle metabolism in cancers. However, the role and mechanism of methionine cycle metabolism in hepatocellular carcinoma are still unknown. In this study, we found that [Cu(ttpy-tpp)Br
2
]Br (Referred to as
CTB
) could induce hepatocellular carcinoma cells senescence, which is a new copper complex synthesized by our research group. Interestingly,
CTB
induces senescence by inhibiting the methionine cycle metabolism of
HCC
cells. Furthermore, the inhibitory effect of
CTB
on the methionine cycle depends on mitochondrial carrier protein SLC25A26, which was also required for
CTB
-induced
HCC
cells senescence. Importantly, we found that
CTB
-induced upregulation of SLC25A26 could cause abnormal methylation of TERT and inhibited TERT expression, which is considered to be an essential cause of cell senescence. The same results were also obtained in vivo,
CTB
inhibits the growth of subcutaneously implanted tumors in nude mice and promoted the expression of senescence markers in tumor tissues, and interference with SLC25A26 partially offset the antitumor effect of
CTB
.
...
PMID:Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26. 3304 23
