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Query: UMLS:C1862200 (RHE)
 1,093 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The term haemangioendothelioma has been used in the past for a number of vascular lesions, which vary not only by their morphological features, but more importantly, also by their biological behavior. In the recent WHO-classification of mesenchymal tumours haemangioendotheliomas have been defined as vascular tumours of "intermediate" or "borderline" malignancy, and spindle cell haemangioendothelioma (SHE), epithelioid haemangioendothelioma (EHE), and rare malignant endovascular papillary angioendothelioma (Dabska's tumour) were included in this category. To this list might be added the more recently delineated kaposiform (KHE), retiform (RHE), polymorphous (PHE), and composite haemangioendothelioma (CHE). Although very popular, the concept of "borderline" or "intermediate" malignancy encompasses a wide variety of clinical situations, prognosis, and biological behavior. Therefore uncritical use of the term haemangioendothelioma represents a potential source of confusion to patients and oncologists, and it should not be used without further clarification. SHE was originally described as low-grade angiosarcoma, however, the study of large series with expanded follow-up information clarified that these lesions are often multicentric in one anatomic region, whereas true recurrences are rather rare, and systemic metastases and tumour progression do not occur. Therefore redesignation of these lesions as spindle cell haemangioma has been proposed. EHE of skin and soft tissues represents a distinctive vascular neoplasm characterized by nests and cords of epithelioid endothelial tumour cells with characteristic cytoplasmic vacuoles, which are set in a myxohyaline matrix. The reported rates of systemic metastases (20-30%), and tumour related death of patients (13-17%) in EHE, and the occurrence of multicentric EHE argue against the classification of EHE as a low-grade or "borderline" malignant neoplasm; EHE should be better regarded as a clearly malignant vascular tumour (G2). Although it seems that KHE is associated with a high mortality rate, the deaths are almost always related to locally invasive effects or as result of bleeding and consumption coagulopathy. So far no metastasizing case of KHE has been reported, and it seems that the prognosis in KHE is mainly related to size, anatomical site and depth of the lesion. KHE should be classified as a locally aggressive, non-metastasizing vascular tumour. The remaining entities (RHE, Dabska's tumour, PHE, and CHE) are characterized by an infiltrative growth, a high rate of (often repeated) local recurrences, and a definitive risk of metastases. Therefore these lesions fulfil criteria for low-grade malignant vascular neoplasms.
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PMID:[Hemangioendotheliomas--evolution of a concept of a heterogeneous group of vascular neoplasms]. 1009 22

Organic-inorganic nanohybrids with nanoscale architectures and electrocatalytic properties are emerging as a new branch of advanced functional materials. Herein, nanohybrid organic-inorganic nanosheets are grown on carbon paper via a pulse-electrochemical deposition technique. A benzo[2,1,3]selenadiazole-5-carbonyl protected dipeptide BSeFL (BSe = benzoselenadiazole; F = phenylalanine; and L = leucine) cross-linked with Ni2+ ions (Ni-BSeFL) and nickel hydroxide (Ni(OH)2) in a BSeFL/Ni(OH)2 electrode exhibits stable electrocatalytic activity toward urea oxidation. The cross-linked nanosheet morphology of nanohybrids was optimized by controlling the reduction potential during pulse electrodeposition. The BSeFL/Ni(OH)2 (-1.0 V) nanohybrid deposited at -1.0 V provides abundant active sites of Ni3+ with low charge transfer resistance (RCT) and high exchange current density (J0) at the electrocatalytic interface. The nanohybrids with Ni-BSeFL and Ni(OH)2 show low overpotential and superior stability for electrocatalytic urea electro-oxidation. The BSeFL/Ni(OH)2 (-1.0 V) nanohybrid based electrode requires a low potential of 1.30 V (vs. RHE) to acquire a current density of 10 mA cm-2 for the urea oxidation reaction (UOR) in urea containing alkaline solution which is lower than that for water oxidation in alkaline solution (1.49 V vs. RHE). The organic-inorganic nanohybrid BSeFL/Ni(OH)2 (-1.0 V) shows durability over 10 h for oxygen evolution and urea electro-oxidation, thereby confirming the BSeFL/Ni(OH)2 (-1.0 V) nanohybrid-based electrode as an efficient electrocatalyst.
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PMID:Pulse electrodeposited, morphology controlled organic-inorganic nanohybrids as bifunctional electrocatalysts for urea oxidation. 3321 Jun 94