Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1862103 (
BDC
)
459
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To elaborate the understanding of diphosphonate kinetics, a non compartmental analysis is introduced. Using continuous infusion of 99mTc-methylene diphosphonate (Tc-
MDP
) and 51Cr-EDTA, as a cotracer, the diphosphonate clearance to bone (
BDC
) can be calculated.
BDC
is found to correlate well with the 24 h whole body retention of diphosphonate (WBR) (r = 0.89, P less than 0.01) when renal function is normal, but not in cases of reduced 51Cr-EDTA clearance. These findings indicate that
BDC
measurements are superior to the WBR technique in the estimation of bone turnover, especially when renal function is reduced. The
BDC
measurements may also constitute a useful tool for studies of diphosphonate uptake in bone, the foundation of bone scintigraphy.
...
PMID:Studies on diphosphonate kinetics. Part II: Whole body bone uptake rate during constant infusion--a refined index of bone metabolism. 310 91
