Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1855645 (KPC)
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Human Gene/Protein
ZNF251 13.4
KPC2 13.3
ubiquinol-cytochrome c reductase core protein I 12.8
KPB1 12.4
VIM 12.4
truncated adenomatous polyposis coli 12.1
KPC1 12.0
otubain 1 11.8
SME 11.8
PP36 11.6
ST15 11.2
GES 11.2
NCAPD3 11.1
IMP 11.0
IMP-2 10.9
K73 10.7
plexin D1 10.5
IMP-1 10.5
TEAD3 10.4
PIRH2 10.3
AMAP1 10.1
MBL 10.0
SEMA3D 9.9
CTX 9.9
CR16 9.9
isoform a 9.9
ST14 9.8
KOX 9.8
NTE 9.8
doublecortin-like kinase 9.6
CARB 9.6
SVH 9.4
PPP1CB 9.3
CXCL17 9.3
HOXA2 9.2
AIM-1 9.0
MOX 9.0
UQCRC1 8.8
actin-binding protein 280 8.7
Fox-2 8.7
porin 8.6
PME-1 8.6
ST13 8.6
deleted in azoospermia-like 8.5
KCP 8.4
K24 8.4
GN2 8.4
K35 8.4
CPO 8.4
K37 8.4
SGCA 8.4
Doublecortin-like kinase 1 8.3
cathepsin X 8.3
E.coli) 8.2
STI1 8.2
putative ATPase 8.2
ST18 8.1
DNA mismatch repair protein 8.1
NEDD4L 8.1
SIM 7.9
cyclin-dependent kinase inhibitor p27 7.8
IVD 7.8
PER 7.7
Matrix metalloproteinase 9 7.6
FAS ligand 7.6
K36 7.6
KMT2C 7.6
NMD 7.6
Hox protein 7.5
TEM 7.4
p48 7.4
metastasis-associated protein 7.3
FBL 7.3
BNIP3L 7.2
MIR 7.1
EFG 7.1
Bfl-1 7.1
mda-7 7.1
MIC 7.1
SAPS 7.0
LN1 7.0
dystrophin-associated glycoprotein 7.0
Integrase 7.0
prolyl-tRNA synthetase 7.0
PFKFB3 7.0
MSH receptor 6.9
MGA 6.9
APOBEC-1 6.9
ST7 6.9
Brca1 6.8
Skp2 6.8
SPN 6.8
ST4 6.7
MAST 6.7
ACT 6.7
Vor 6.6
BCD 6.6
IL-20 6.6
LIP 6.6
CIT 6.5
ASCT2 6.5
IAR 6.5
ECO 6.5
A-3 6.5
PSR 6.4
Nix 6.4
DDB2 6.4
SKP2 6.4
CPE 6.4
CLS 6.4
erm 6.4
HBD 6.3
pannexin 1 6.3
KMT2D 6.3
Cyr61 6.3
leucyl-tRNA synthetase 6.3
PDCD4 6.2
PSE 6.2
cell adhesion molecule 1 6.2
KSP 6.2
STAR 6.1
TFP 6.1
MPI 6.0
CCL20 6.0
ARF6 6.0
L1CAM 6.0
VISA 6.0
ADC 6.0
ARI 5.9
REC 5.9
CRL4 5.9
STEP 5.9
plexin 5.9
E.coli 5.9
L1 cell adhesion molecule 5.9
protease-activated receptor-1 5.8
20 copies 5.8
K17 5.8
PVD 5.7
TREK-1 5.7
K27 5.7
dual-specificity phosphatase 5.7
IMPACT 5.6
PC1 5.6
RED 5.6
Pseudomonas 5.6
TRAMP 5.6
short-chain dehydrogenase/reductase 5.6
PRC 5.6
transporter associated with antigen processing 5.6
DEF 5.6
KRAS 5.5
CRM1 5.5
LAMP 5.5
annexin A2 5.5
Gli2 5.5
FAC 5.4
K15 5.4
LAM 5.4
PIM 5.4
MUC4 5.4
H21 5.4
LAP 5.4
FIB 5.4
HPD 5.4
annexin II 5.4
PEA3 5.3
CTB 5.3
E. coli) 5.3
DAC 5.3
MPN 5.3
S19 5.2
NPS 5.2
ARG 5.2
TOF 5.1
GLI1 5.1
alpha B-crystallin 5.1
ROCK1 5.1
Cx26 5.1
RIP1 5.1
NGAL 5.0
ACHN 5.0
SMRT 5.0
Cathepsin B 5.0
ACC 5.0
CK20 5.0
PC2 5.0
MAX 5.0
HAP 4.9
PD1 4.9
orf 4.9
HA2 4.9
IDA 4.9
ST1 4.9
ubiquitin ligase 4.8
XPC 4.8
HER3 4.8
APH 4.8
FAP 4.8
PDC 4.8
STA 4.8
p27 4.8
ANT 4.8
IA-2 4.8
P11 4.8
FMD 4.8
transcription factor Sp1 4.7
uteroglobin 4.7
ESX 4.7
H10 4.7
MPC 4.6
deubiquitinating enzyme 4.6
p27Kip1 4.6
P2Y2 4.6
cyclin D2 4.6
ASP 4.6
CD64 4.6
SCF 4.6
HBA 4.6
GLUT2 4.6
MTB 4.6
Polymerase 4.6
DMA 4.5
ELF 4.5
version 1 4.5
ECL 4.5
K-ras 4.5
PTP 4.5
cytidine deaminase 4.5
CDX2 4.5
FLASH 4.5
ULK1 4.4
MRSA 4.4
Boc 4.4
PAD 4.4
K14 4.4
mesothelin 4.4
MCC 4.4
S10 4.4
LOX 4.4
CD24 4.4
ICE 4.4
GDNF 4.4
Smoothened 4.3
CIP 4.3
chaperonin 4.3
non-active 4.3
cyclin-dependent kinase 4.3
ICS 4.3
mutant p53 4.3
SPA 4.3
mannose receptor 4.3
LMP 4.3
SDH 4.2
RIF 4.2
TAT 4.2
MCP-3 4.2
HSP27 4.2
cytokeratin 19 4.1
kit 4.1
MMR 4.1
AML 4.1
MIA 4.1
RCC 4.1
Jak2 4.0
PKC-alpha 4.0
MLR 4.0
SMS 4.0
GroES 4.0
UTI 4.0
NRC 4.0
FOS 3.9
proteinase 3 3.9
4-1BB 3.9
SMAD4 3.9
EMT 3.9
Slug 3.9
PD-L1 3.9
API 3.8
PDI 3.8
PD-1 3.8
N-cadherin 3.8
glycosyltransferase 3.8
PARP1 3.7
RET 3.7
mouse) 3.7
ST2 3.7
tat 3.7
ADL 3.7
vascular endothelial growth factor A 3.6
adapter protein 3.6
Nestin 3.6
RACE 3.6
IL6 3.6
CMS 3.6
integrase 3.6
CD133 3.6
INS-1 3.6
ECM 3.5
zinc finger protein 3.5
K10 3.5
fur 3.5
E3 ubiquitin ligase 3.5
methyltransferase 3.5
chondroitinase 3.5
Yes 3.5
B7-H3 3.5
transmembrane receptor 3.5
adenomatous polyposis coli 3.5
BAL 3.5
cathepsin L 3.5
PNP 3.5
hTERT 3.4
factor V 3.4
DAF 3.4
TMP 3.3
XIAP 3.3
MMP9 3.3
PP1 3.3
cyclin-dependent kinase inhibitor 3.3
more...
Disease
KPC 14.4
SME 11.6
CTX 9.8
PanIN 9.7
SBL 9.6
Klebsiella 9.5
KHM 9.4
SPM 9.1
Klebsiella pneumoniae infection 9.0
Endogenous endophthalmitis 8.4
PER 7.7
Escherichia coli bacteremia 7.7
Delhi 7.5
TEM 7.4
TEM 7.3
FBL 7.3
Nosocomial pneumonia 7.1
FSI 7.0
Spontaneous pneumothorax 6.7
Neonatal sepsis 6.7
Vidal 6.7
BCD 6.6
Candidemia 6.5
Rotor 6.5
lower urinary tract infection 6.5
Proteus 6.5
HBD 6.3
MIN 6.3
MIN 6.3
IS1 6.2
chest infection 6.0
pancreatic cancer 6.0
VISA 5.9
nosocomial infection 5.9
PDR 5.8
CLS 5.7
MRD 5.6
HPC 5.5
bacteremia 5.5
complex partial seizures 5.4
blood disorder 5.2
Infections 5.2
HPP 5.2
LAP 5.2
NPS 4.9
erythroblastosis 4.9
PDC 4.7
FMD 4.7
urinary tract infection 4.7
orf 4.6
CMV retinitis 4.5
PTP 4.4
proliferative diabetic retinopathy 4.3
adenocarcinoma 4.2
MRSA 4.2
pneumonia 4.0
EMT 3.9
liver metastases 3.9
INS 3.9
LDA 3.9
FMD 3.9
Infection 3.9
pyelonephritis 3.8
lymphangioleiomyomatosis 3.8
SMS 3.7
colibacillosis 3.7
tumor initiation 3.6
Poland 3.5
ICS 3.5
brain abscess 3.4
Nelson 3.4
mediastinitis 3.3
cellulitis 3.3
macular edema 3.3
EPI 3.3
Wiskott-Aldrich syndrome 3.3
ICC 3.2
ICC 3.2
Thymus 3.1
Thymus 3.1
Thymus 3.1
liver abscess 3.1
tumor progression 3.1
Merkel cell carcinoma 3.0
decubitus 3.0
hematologic malignancies 3.0
bacteriuria 2.9
sepsis 2.9
sepsis 2.8
invasive cancer 2.8
Shigella 2.8
infectious diseases 2.8
endophthalmitis 2.7
fasciitis 2.6
opportunistic infection 2.6
connective tissue disease 2.5
Dissociation 2.5
gastroenteritis 2.5
osteomyelitis 2.5
SDS 2.5
follicular lymphoma 2.4
FAS 2.4
aggressiveness 2.4
meningitis 2.4
tumor growth 2.4
BMD 2.4
empyema 2.3
Still 2.3
familial adenomatous polyposis 2.3
chondrosarcoma 2.3
multiple endocrine neoplasia 2.2
tumorigenesis 2.2
lymphopenia 2.2
minimal residual disease 2.1
primary tumor 2.1
APC 2.1
peritonitis 2.1
pericarditis 2.1
papilloma 2.1
respiratory infection 2.1
pancreatitis 2.0
lung metastases 2.0
PSA 2.0
oral cancer 2.0
respiratory disease 2.0
mimicry 1.9
muscular dystrophy 1.9
ARF 1.9
renal impairment 1.8
cystic fibrosis 1.8
COPD 1.8
addiction 1.6
chronic pancreatitis 1.6
hypertrophic cardiomyopathy 1.5
leukopenia 1.5
endocarditis 1.5
diabetic retinopathy 1.4
pneumothorax 1.3
Best 1.3
carcinogenesis 1.2
pulmonary tuberculosis 1.2
Yersinia 1.1
tumor 1.1
acute pancreatitis 1.0
SCID 1.0
Chlamydia 0.8
ATM 0.7
Mycobacterium 0.7
chronic obstructive pulmonary disease 0.6
Mycoplasma 0.6
metastases 0.5
respiratory failure 0.5
dengue 0.5
bacterial infection 0.5
neutropenia 0.3
West 0.2
colitis 0.2
cancer 0.1
cholera 0.1
type 1 diabetes 0.1
renal cell carcinoma -0.1
colorectal cancer -0.3
cytomegalovirus -0.4
aggression -0.4
hyperglycemia -0.4
Hodgkin's disease -0.5
fits -0.5
renal failure -0.6
lung cancer -0.7
tuberculosis -0.8
malaria -1.1
leukemia -1.1
diabetes -1.4
obesity -1.5
Parkinson's disease -1.5
cardiovascular disease -1.6
immunodeficiency -1.7
lymphoma -1.7
carcinoma -1.8
breast cancer -1.9
Symptom
asthenia 3.0
cachexia 2.9
apathy 2.4
ENT 2.0
exhaustion 0.7
chest pain 0.3
cough -0.1
starvation -0.2
diarrhea -1.4
pain -3.6
Drug
2-Butanol 10.9
Fosfomycin tromethamine 10.8
CAZ 10.3
Tylan 10.2
Ertapenem 10.0
CTX 9.9
CTX 9.9
Meropenem 9.8
Colistin 9.8
Ceftazidime 9.7
Meropenem 9.7
Doripenem 9.4
Temocillin 9.4
CTX 9.0
AMK 8.8
IPM 8.1
CPO 7.7
CFX 7.1
Check 6.7
ACT 6.6
CLS 6.2
SMP 5.8
SBT 5.8
AZT 5.2
Everolimus 5.0
ampicillin 4.8
TAT 4.8
CTC 4.4
DMAP 4.3
DPA 4.1
CTC 4.1
Pronase 4.1
Spectrum 4.0
EPI 3.4
Spectrum 3.0
ETS 3.0
AZT 3.0
Retinoic acid 2.7
Gel 2.5
lactose 2.4
Portal 2.4
Asn 1.9
Bifidobacterium 1.9
Biopolymers 1.3
ENT 1.3
ABC 1.3
citric acid 1.1
CSF 0.5
MAP 0.5
vitamin E 0.3
ROS 0.2
lysine 0.1
Leaf -0.0
Monit -0.7
Enzyme
NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase 13.4
matriptase 7.8
beta-lactamase 7.6
cathepsin X 7.2
MDR 7.2
restriction-modification system 6.9
neuropathy target esterase 6.7
mercuric reductase 6.5
leucyl-tRNA synthetase 6.2
LIS 6.1
endo-beta-galactosidase 6.1
endo-beta-galactosidase 5.4
RNase P 5.0
SMP 5.0
deoxyribonuclease 4.8
TAT 4.8
S1 nuclease 4.6
cytidine deaminase 4.5
furin 4.3
chaperonin 4.3
proprotein convertase 4.3
cathepsin L 3.5
BAL 3.5
chondroitinase 3.4
hyaluronidase 3.4
chondroitinase 3.3
hyaluronidase 3.2
DNA methyltransferase 3.1
cathepsin B 2.4
subtilisin 2.3
proteasome 2.2
IKK 2.1
deaminase 2.1
AST 1.8
caspase-1 1.8
papain 1.7
urease 1.6
MAP 1.5
urease 1.5
APC 1.4
plasmin 1.3
topoisomerase 1.2
transcriptase 1.2
CD10 1.1
topoisomerase 1.1
focal adhesion kinase 1.0
ACS 0.9
protein kinase 0.9
ERK 0.9
PARP 0.7
mitogen-activated protein kinase 0.4
protein kinase C 0.4
DNA polymerase 0.3
RNA polymerase 0.3
MEK 0.3
endonuclease 0.2
luciferase 0.2
lysozyme 0.0
aspartate aminotransferase -0.0
lactate dehydrogenase -0.4
thrombin -0.6
trypsin -1.0
catalase -1.4
ATPase -1.6
peroxidase -1.6
Compound
Fluopsin C 13.4
3-fluorobenzamide 12.4
IMP 10.9
Colistin sulfate 10.7
Ceftazidime 9.7
MHT 9.7
Aerobactin 9.1
3GC 9.1
CTX 9.0
Apramycin 9.0
A-14 8.9
Tigecycline 8.8
Imipenem 8.6
SPM 8.3
BIC 8.3
Garcinol 8.3
Clavulanic acid 8.2
Fosfomycin 8.2
PAPP 8.1
DIM 8.1
Polymyxin B 8.0
Aztreonam 7.9
Cloxacillin 7.8
NIX 7.6
Cefepime 7.6
Cerivastatin 7.6
PMB 7.5
2-octanol 7.5
PC-2 7.4
phenylboronic acid 7.3
TEM 7.3
Amikacin 7.2
Lupeol 7.1
MIC 7.1
MDR 7.0
CoM 6.9
DHA 6.9
Bicuculline 6.8
BES 6.8
DHA 6.8
MGA 6.7
Sulbactam 6.7
CLS 6.4
Gemcitabine 6.3
BON 6.3
2-butanol 6.3
Gemcitabine 6.3
DHA 6.3
9H-carbazole 6.2
2-butanone 6.2
2-butanone 6.2
TET 6.1
TET 6.1
MBT 6.0
Ethidium bromide 5.9
K19 5.8
Cefoxitin 5.7
HMM 5.7
HPC 5.6
HPC 5.6
2-butanone 5.6
BAA 5.6
Gentamicin 5.5
Capecitabine 5.4
Tobramycin 5.3
DAC 5.3
APH 5.3
3-hydroxybutyric acid 5.3
NMP 5.2
Probenecid 5.2
Cefotaxime 5.1
TOF 5.1
HBA 5.0
Serine 5.0
Agar 5.0
CIT 5.0
CIT 4.9
HAP 4.9
Rifampicin 4.9
MPC 4.8
IDA 4.8
TMB 4.7
CCP 4.7
Neo 4.7
HfO2 4.7
serine 4.5
Minocycline 4.5
DMA 4.5
DMA 4.5
PABA 4.4
FAP 4.4
FAP 4.4
DPA 4.3
DPA 4.3
SN-38 4.3
DMA 4.2
DPA 4.1
PAN 4.1
DPA 4.1
EDTA 4.1
DPA 4.1
EDTA 4.0
DPA 4.0
Mato 3.9
thiophene 3.9
DPA 3.9
DPA 3.8
DPA 3.8
DPA 3.8
DPA 3.8
DPA 3.8
Alginate 3.8
acrylonitrile 3.7
TMP 3.4
THE 3.4
TMP 3.4
TMP 3.4
acrylonitrile 3.3
thymol 3.3
Ciprofloxacin 3.3
MBC 3.3
MBC 3.2
MIA 3.2
GAL 3.2
Ethylene 3.1
thioglycollate 3.1
NKT 3.1
chalcone 3.1
Vimentin 3.1
Hematoxylin 3.1
BAL 3.0
TMP 2.9
2-propanol 2.9
2-propanol 2.9
piperidine 2.8
piperidine 2.8
AZT 2.7
BMD 2.7
Valproic acid 2.7
succinic acid 2.6
Optimal 2.6
5-FU 2.6
glucose-6-phosphate 2.6
DDE 2.6
SDS 2.5
Congo red 2.5
Triton 2.3
PNP 2.3
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
2-hydroxyethyl 2.2
thiourea 2.2
2-hydroxyethyl 1.9
FK506 1.9
boron 1.8
UDP 1.8
pentose 1.8
hyaluronic acid 1.8
PLA 1.8
pentose 1.8
A 1 1.8
MEK 1.8
pentose 1.7
pentose 1.7
zinc 1.7
ASA 1.5
Clin 1.4
Salt 1.3
sulfate 1.3
acetate 1.3
MAP 1.2
DNA 1.2
isopropanol 1.2
Cholesterol 1.1
Carbon 1.1
CAM 1.1
aspartic acid 1.1
aspartic acid 1.0
water 1.0
ACS 1.0
ACS 0.9
sodium chloride 0.9
aspartic acid 0.9
alanine 0.9
leucine 0.8
retinoic acid 0.8
aspartic acid 0.8
urea 0.7
His 0.7
phenol 0.7
threonine 0.6
TSH 0.5
arginine 0.4
lysine 0.4
cyanide 0.4
Gly 0.3
Asp 0.3
vinyl 0.2
hydrogen 0.2
PEG 0.2
PEG 0.1
NAD 0.1
iron -0.1
copper -0.1
MDA -0.2
Dec -0.2
NADPH -0.2
NADPH -0.2
NAD -0.3
glutamine -0.3
methane -0.3
mercury -0.3
sodium -0.4
silver -0.5
tyrosine -0.6
benzene -0.6
cadmium -0.7
acetic acid -0.7
glycerol -0.9
silicon -1.0
phosphate -1.0
phosphorus -1.1
glucose -1.2
Phe -1.3
nitrate -1.3
oxygen -1.3
salt -1.4
creatinine -1.5
TNF -1.5
ammonium -1.6
ATP -1.6
glutamate -1.8
cysteine -1.8
calcium -2.4
ethanol -2.7
nitrogen -2.9