Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1855645 (
KPC
)
1,473
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Carbapenemase-producing combined porin loss is one of the primary mechanisms for carbapenem resistance. Although mutations in
ompK35
and
ompK36
genes have often been identified in carbapenem-resistant
Klebsiella pneumoniae
, reports on the porin protein gene disruption by insertion sequence (IS) elements are varied. The
ompK36
porin protein gene disruption by IS elements and OmpK36 production loss in six
bla
KPC
-2
-carrying
K. pneumoniae
isolates were detected in this study. IS
903
, IS
Ec68,
and IS
1
insertions were noted in the 3, 2, and 1 isolates, respectively. The six
K. pneumoniae
isolates showed five different pulsed-field gel electrophoresis patterns and belonged to four multilocus sequence typing types,
ST4
, ST11, ST15, and ST39. This study increases our understanding of the genetic background of
KPC
-2 carbapenemases in porin-defective clinical isolates and the contribution of OmpK36 production loss to carbapenem resistance.
...
PMID:Characterization of the Genetic Background of KPC-2-Producing
Klebsiella pneumoniae
with Insertion Elements Disrupting the
ompK36
Porin Gene. 3228 46
