Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1852044 (
HS3
)
171
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Fusion of the Chinese hamster stably transformed Tk+ cells containing chromosomally integrated plasmid with a fragment of human satellite III DNA (
HS3
), with mitomycin C-treated human cells (B-lymphoma, line
Raji
) results in amplification and excision of heterogeneous plasmid material from hamster chromosomes. Some of these plasmids contain
HS3
. Functional activity of
HS3
in the initiation of DNA replication is shown in transient transfection experiments. The results indicate that mitomycin C induces in human cells some trans-acting factors (possibly proteins) activating a replication origin within
HS3
DNA and leading to plasmid replication in situ and their excision from chromosomes.
...
PMID:[Excision of the plasmid containing the inserted human satellite DNA from Chinese hamster chromosomes after fusion of hamster and human cells]. 362 35
