Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1852044 (HS3)
 171 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Escherichia coli strain HS3, metabolically engineered to have Met(-), AHV(r), Ile(L) and AEC(r) characteristics, produced 58.0 g/l of L-threonine, but it was neither salt-tolerant nor osmotolerant; and the growth and threonine production of the strain were severely inhibited both by the addition of NaCl with a concentration higher than 2% and by the presence of glucose with a concentration higher than 10%. Therefore, salt-tolerant mutants were isolated. The salt-tolerant mutants, HS454 and HS528 which were derived from strain HS3, were both tolerant to salt (2%) and hyper-productive. The growth and L-threonine production by the mutant strain HS454 were almost unaffected by a glucose concentration lower than 10%, but gradually reduced with increasing glucose concentration, up to 15%. However, the mutant strain HS528 showed slightly enhanced growth and L-threonine production with increasing glucose concentration, up to 10-12.5%. Strains HS454 and HS528 produced 69.8 g/l and 74.0 g/l of L-threonine, respectively in a 5-1 jar fermentor.
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PMID:Characterization of salt-tolerant mutant for enhancement of L-threonine production in Escherichia coli. 1113 89

Biosurfactant production was studied by Bacillus licheniformis K51, B. subtilis 20B, B. subtilis R1 and Bacillus strain HS3 using molasses or cheese whey as a sole source of nutrition at 45 degrees C. The isolates were able to grow and produce biosurfactant under shaking as well as static conditions. Maximum biosurfactant production was achieved with molasses at 5.0-7.0% (w/v). The biosurfactant retained its surface-active properties after incubation at 80 degrees C at a wide range of pH values and salt concentrations for nine days. Oil displacement experiments in sand pack columns with crude oil showed 25-33% recovery of residual oil.
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PMID:Biosurfactant production using molasses and whey under thermophilic conditions. 1732 39