Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1835664 (
TOC
)
2,763
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pituitary is an endocrine gland with ability to uptake diverse radiopharmaceuticals and, therefore, susceptible to be investigated by nuclear medicine diagnostic procedures. Although this topic has been scarcely scrutinized, we have data indicating that somatostatin receptor scintigraphy with
111
In-DTPA-D-Phe-octreotide or
99m
Tc-EDDA/HYNIC-
TOC
may be of clinical utility in the diagnosis of some pituitary adenomas (PA). Only a few studies have evaluated the diagnostic performance of
99m
Tc-MIBI and
99m
Tc (V)-DMSA scintigraphy in pituitary disease. Scintigraphy using
123
I-methoxybenzamide (
123
I-IBZM) might be useful in macroprolactinomas expressing dopamine D2 receptors.
Pituitary gland
does not usually accumulate 2-deoxy-2-[
18
F]fluoro-d-glucose (
18
F-FDG) and, therefore, it is not visualized on positron emission tomography (PET) imaging studies with this radiotracer. The pituitary uptake on
18
F-FDG PET/CT scans performed in the follow-up of oncological patients are uncommon. However, 60% of these incidental findings are due to PA, mainly non-functioning pituitary macroadenomas, and a small percentage to metastases or other pituitary lesions. Interestingly,
18
F-FDG PET/CT may identify hypophysitis induced by different immunotherapeutic agents used in cancer patients. Positive
18
F-FDG uptake has been reported in a high percentage of patients with PA, mainly macroadenomas and it seems that there is correlation between tumor size and SUVmax.
68
Ga-DOTA-TATE PET/CT may identify functioning and non-functioning PA, although this technique is more useful in the detection of remaining normal pituitary tissue after transsphenoidal adenomectomy, and in the confirmation of recurrence of functioning PA, such as thyrotroph-secreting PA. Furthermore,
68
Ga-DOTA-TATE uptake has potential therapeutic implications on molecular-targeted therapy. Lastly, other radiopharmaceuticals that have shown to be taken up in some patients with pituitary disease include
18
F-DOPA (prolactinoma),
11
C-methionine (residual or recurrent PA), O-(2-
18
F-fluoroethyl)-l-tyrosine (metastasis),
18
F-choline (silent adenoma, ectopic corticotropinoma), and
13
N-ammonia (hypopituitarism).
...
PMID:The pituitary in nuclear medicine imaging. 3151 79
