Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1832588 (PSS)
 2,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Currently there are no widely accepted criteria for the diagnosis of MCTD. In this work we attempted to define the clinical profile of a group of 68 patients with anti nRNP antibodies, detected by immunoprecipitation in 0.6% agarose. The diagnosis of each collagen vascular disease was established in every patient, who met with the strict diagnostic criteria either at clinical presentation or during the follow-up period. Twenty-eight patients had SLE, 9 had classical erosive RA, three had PSS and one had PM. The only distinctive features in the group of SLE with anti nRNP was an increased incidence of anti Sm antibodies (p less than 0.05). In the RA group there was a trend towards a high frequency of Raynaud's phenomenon and swollen hands. At clinical presentation twenty-seven patients did not fulfil enough criteria to be diagnosed of any of the well-defined collagen vascular disease. They presented an undifferentiated syndrome, characterized clinically by Raynaud's phenomenon (100%), swollen hands (88.9%) and joint symptoms (88.9%), with scarce tendency of developing severe systemic manifestations. The main laboratory abnormalities in this group were hypergammaglobulinemia, mildly increased ESR, abnormal levels of CIC, negative anti nDNA and anti Sm antibodies, and the virtual absence of hypocomplementemia. During a clinical course of 96 +/- 72.5 months only one patient evolved into another collagen disease (SLE). The clinical course in the remaining cases, was stable improving with low doses of prednisone and/or NSAID. We suggest considering this undifferentiated syndrome as a distinct entity, for which the already classical term of MCTD could be reserved.
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PMID:Clinical profiles of patients with antibodies to nuclear ribonucleoprotein. 633 22

Program evaluation data from 451 veterans treated with at least four sessions of prolonged exposure (PE) within a U.S. Department of Veterans Affairs outpatient posttraumatic stress disorder program were examined to explore to what degree change by Session 8 predicted achieving meaningful change (MC; 50% reduction on the Posttraumatic Stress Disorder Symptom Scale-Self-Report [PSS-SR]) after Session 8. The overall MC rate was 33.4%. A survival analysis determined the number of sessions required to achieve MC on the PSS-SR had a modal number of nine sessions. Logistic regressions found that younger veterans and those from more recent wars were more likely to achieve MC than the rest of the sample. An analysis of a subset of 156 patients who had more than eight sessions, had not achieved MC by Session 8, and had a Session 8 PSS-SR available found that those who had a reduction of at least 10% on the PSS-SR by Session 8 (71 patients) had a 42.3% rate of MC, while only 7.1% of the 85 patients with a less than 10% reduction by Session 8 went on to achieve MC. Approximately 636 post-Session 8 clinician hours were spent treating these 85 patients with PE to have only 6 achieve MC. These outcomes suggest that patients without an at least 10% reduction on the PSS-SR by Session 8 are unlikely to achieve MC with additional PE sessions; therefore, alternate treatments or augmentation of PE should be considered. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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PMID:Extending prolonged exposure for veterans with posttraumatic stress disorder: When is enough really enough? 3033 16

Mental illness is a major public health concern negatively affecting persons across multiple domains. To address this, health care systems have prioritized access to care and use of empirically supported treatments to better serve those with psychiatric concerns. Rates of dropout from psychotherapy are high, especially in routine clinical settings. Peer support has been promulgated as fostering treatment engagement and completion due to a connection forged from common experience (e.g., military service, psychiatric diagnosis, etc.). As such, the Veterans Health Administration has invested heavily in peer support, although there is limited direct evidence that it enhances treatment engagement or completion. The current study advances upon prior research, showing positive effects of a Cognitive Behavioral Therapy-Pretreatment Intervention (CBT-PTI) on individual therapy outcomes (Lusk, Lyubkin, Chermack, Sanborn, & Bowersox, 2016), by comparing CBT-PTI initial engagement and completion among 352 veterans who met with either a Peer Support Specialist or a Program Support Assistant. Logistic regressions were used to assess the effects of significant unadjusted predictors on CBT-PTI initial engagement and completion, and Mann-Whitney tests were used to further describe differences between veterans who met with PSA versus PSS. Support for the role of PSS was found for CBT-PTI completion, and there was a trend for engagement, although further research is needed. This study provides preliminary support for the use of PSS in fostering CBT-PTIs in routine clinical settings, although further study is warranted to confirm and expand support. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PMID:Predictors of CBT-pretreatment intervention engagement and completion: Evidence for peer support. 3038 47

Objective: PTSD in female veterans and service members (SMs) is understudied, and new, effective treatments for PTSD are needed. Reconsolidation of Traumatic Memories (RTM) is a brief, manualized treatment for PTSD previously piloted in RCTs of male veterans and SMs. Here we examine RTM's effect on military women with PTSD. Method: We report a waitlist RCT using 30 military-connected females with DSM-IV-TR PTSD diagnoses, including current-month nightmares or flashbacks. Trauma types include military sexual trauma, other sexual traumas, combat, and other trauma types. Participants were randomized to treatment or waitlist. Of those enrolled, 97% completed treatment. Independent psychometricians, blinded to treatment condition, evaluated participants at intake, postwait, and two weeks post. The clinician took follow-up measures at six months and one year. The primary measure was the PTSD Symptom Scale-Interview (PSS-I). The secondary measure was the PTSD Checklist. Participants received up to three 120-min sessions of RTM. Results: RTM eliminated intrusive symptoms and significantly decreased symptom scale ratings in 90% (n = 27) of participants, versus 0% of controls (p < .001). Two-week treatment group PSS-I scores dropped 33.9 points versus 3.9 points for postwait controls (g = 3.7; 95% CI [2.5, 4.8]; p < .001). Treatment results were stable to 1 year. Conclusions: RTM effectively treated PTSD, independent of trauma source in female SMs and veterans effectively replicating previous results in male populations. Further research is recommended. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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PMID:An open-label, randomized controlled trial of the reconsolidation of traumatic memories protocol (RTM) in military women. 3321 19