Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1832588 (
PSS
)
2,979
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In goldfish, growth hormone (GH) transiently rises 30 min after meals, returning to baseline at 1 h postmeal. Somatostatin (SRIF) is the major inhibitor of GH release. Three cDNAs encoding pre-pro-SRIF (
PSS
) have been previously cloned from goldfish brain:
PSS
-I, which encodes SRIF-14;
PSS
-II, which is potentially processed into gSRIF-28 that has [Glu(1),Tyr(7)(,)Gly(10)]SRIF-14 at the COOH terminus; and
PSS
-III, which encodes [Pro(2)]SRIF-14 at its COOH terminus. In goldfish,
bombesin
(
BBS
), mimicking the endogenous gastrin-releasing peptide (GRP), acutely suppresses food intake and also stimulates GH release. Ghrelin was recently characterized in goldfish as a GH secretagogue and an orexigen. In this paper, we studied the changes in SRIF mRNA levels during feeding and analyzed the influences of
BBS
and ghrelin peptides on forebrain
PSS
expression. The results showed a 60% reduction in
PSS
-II mRNA after meals, but no changes in the expression of
PSS
-I and
PSS
-III were found. Intraperitoneal injections of 100 ng/g body wt of
BBS
increased GH secretion and decreased
PSS
-I and
PSS
-II gene expression. Intraperitoneal injection of goldfish ghrelin (100 ng/g body wt) transiently increased the serum GH levels and increased
PSS
-I, while decreasing
PSS
-II mRNA levels. Ghrelin (50 ng/g body wt) blocked the effects of
BBS
(100 ng/g body wt) on
PSS
-I but not on
PSS
-II expression. Coadministration of
BBS
and ghrelin decreased only the
PSS
-II gene expression. We conclude that the interactions between
BBS
/GRP and ghrelin can account for the postprandial variations in serum GH levels and the forebrain expression of
PSS
-II. Furthermore, we demonstrate that intraperitoneal administration of
BBS
reduces the ghrelin expression levels in the gut. Thus the inhibition of production of ghrelin in the gut may contribute to the satiety effects of
BBS
/GRP peptides.
...
PMID:Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide. 1574 4
