Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1832588 (PSS)
 2,979 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

PEM capsules have been proposed for vehicles of drug microencapsulation, with the release triggered by pH, salt, magnetic field, or light. When built on another carrier encapsulating drugs, such as nanoparticles, it could provide additional release barrier to the releasing drug, providing further control to drug release. Although liposomes have received considerable attention with PEM coating for sustained drug release, similar results employing PEM built on poly(lactic-co-lycolic acid) (PLGA) particles is scant. In this work, we demonstrate that the build-up pH and polyelectrolyte pairs of PEM affect the release retardation of BSA from PLGA particles. PAH/PSS pair, the most commonly used polyelectrolyte pair, was used in comparison with PLL/DES. In addition, we also demonstrate that the release retardation effect of PEM-coated PLGA particles diminishes as the particle size increases. We attribute this to the diminishing relative thickness of the PEM coating with respect to the size of the particle as the particle size increases, reducing the diffusional resistance of the PEM.
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PMID:Release retardation of model protein on polyelectrolyte-coated PLGA nano- and microparticles. 2464 68

Introduction With an emphasis on good grades and a high level of performance, studying dentistry can be stressful and may attract a greater number of students with perfectionist strivings. Prolonged stress can lead to mental ill-health, including a risk of burnout and psychological distress.Aims To examine the level and sources of stress, psychological distress and burnout in UK dental students. Perfectionism was also measured to see if dental students showed high levels of perfectionism and how this may relate to psychological outcomes. Finally, coping strategies were assessed.Materials and methods BDA student members were invited to take part in an online survey using validated measures examining stress (DES, PSS), burnout (OLBI-S), perfectionism (short APS) and coping (brief COPE) in UK dental students.Results Four hundred and twelve students from all UK dental schools completed the survey. High levels of stress, burnout and psychological distress were found, which generally increased as the course went on. Thirty-five percent of students were identified as maladaptive perfectionists and were shown to exhibit increased levels of stress, burnout and psychological distress, and a greater use of ineffective coping strategies.Conclusions Stress management needs to be taught as part of the dental education curriculum and should include information about coping strategies, as well as maladaptive perfectionism and how to address this.
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PMID:Stress, psychological distress, burnout and perfectionism in UK dental students. 3318 44