Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C1832588 (
PSS
)
2,979
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The interaction of 1,1'-diethyl-2,2'-cyanine (
PIC
), a non-fluorescent cationic dye known to form emissive J-aggregates in aqueous solutions, with the polyelectrolyte poly(styrenesulfonate) (
PSS
) is investigated by absorption and fluorescence spectroscopy. Depending on the amount of polyelectrolyte added, three regimes are identified. At a large excess of
PIC
, there is an equilibrium between the
PIC
monomer and a non-fluorescent
PIC
aggregate characterized by a strong absorption band centered at 565 nm. As the amount of
PSS
increases, we observe the growth of the
PIC
J-aggregate onto the
PSS
backbone, characterized by a sharp absorption band at 572 nm and a narrow emission at 577 nm. At a large excess of
PSS
, the major species consists of
PIC
molecules adsorbed independently along the polyelectrolyte chains.
...
PMID:Investigation of pseudoisocyanine aggregates formed on polystyrenesulfonate. 1265 22
Dendrimer-based
PIC
micelles are novel nanostructures from the assembly of dendrimers with polyion-neutral diblock copolymers. Because of the branched and three-dimensional structure of dendrimers, understanding the electrostatic assembly is challenging yet essential for manipulating the formation and property of the
PIC
micelles. Herein, we present the pH effects on the assembly of amine-terminated PAMAM dendrimers with
PSS
92
-
b
-PEO
113
diblock copolymers. The step-wise protonation of primary and tertiary amine groups of PAMAM allows us to manipulate the number of the positive charges by tuning pH. We find that the assembly based on the surface charges of PAMAM from G2 to G7 at pH 7 leads to well-defined micelles with high stability against salt. At pH 3, both the interior and surface charges contribute to the assembly, and the formed micelles are sensitive to ionic strength, namely, increasing salt concentration results in the formation of elongated (G2-G5) or bigger (G7) aggregates. Our study reveals the pH manipulation on the assembly of PAMAM dendrimers with linear polyelectrolytes and displays new findings that shall be helpful for understanding the assembly of asymmetric polyelectrolytes, as well as for designing new
PIC
micelles and functional soft nanocarriers.
...
PMID:Effects of pH on the Formation of PIC Micelles from PAMAM Dendrimers. 3261 Sep 10
