Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Stereotactic radiosurgery was used in the treatment of 126 patients with acoustic neurinomas up to 30 mm in diameter from 1969 to 1984. Adequate follow-up data (mean follow-up period 4.7 years) were available for 111 (116 ears) of these 126 patients; of these 111 patients, 64 (65 ears) had a pure-tone threshold of less than 90 dB before the treatment and were followed up audiologically. Preserved hearing was found in 26% of the ears one year postoperatively. Shrinkage of the tumour was obtained in 44% and arrest of its growth in 42%. There was no mortality related to the radiosurgical treatment. Transitory facial weakness was noted in 15% of the patients (3% in 1983-84). Eighteen per cent of the patients had some, usually transitory, trigeminal dysfunction. The stapedius reflex threshold was improved in 13 ears (20%). In one patient the audiological tests became pathological in the contralateral ear during growth of a new tumour. Initially the stapedius reflex threshold was elevated, and 11 months later the BRA pattern also became abnormal.
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PMID:Audiological findings after stereotactic radiosurgery in acoustic neurinomas. 305 87

A 69-year-old man visited a clinic for left leg weakness. With suspicions of lung cancer and a metastatic brain tumor, he was referred to our hospital and was diagnosed with large cell neuroendocrine carcinoma, cT1bN0M1b (BRA), stage IV. After stereotactic radiosurgery for his brain metastasis, he was treated with chemotherapy containing cisplatin and irinotecan. A week after initiating chemotherapy, he suddenly developed severe right leg pain and adynamia. A computed tomography angiogram revealed occlusion of the right common femoral artery, and percutaneous thrombectomy was performed. The symptoms resolved completely, and he was discharged without any sequelae or recurrence. Acute arterial occlusion of the limbs during chemotherapy is uncommon and requires prompt diagnosis and treatment; hence, caution should be paid when it is clinically suspected.
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PMID:[A Case of Acute Arterial Occlusion of the Lower Limb during Chemotherapy for Lung Cancer]. 2721 93