Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 73-year-old female complained of pain in the right lower-abdomen and medial aspect of the distal thigh after a gynecological operation. Computer tomography and MRI findings excluded obturator canal herniation or lumbar plexopathy. Both lumbar epidural block and obturator nerve block with local anesthetics were effective, except their limited duration of pain relief and muscle weakness for several hours after the blockade. Treatment with radio-frequency lesion of 50 degrees C for 60 seconds of the right obturator nerve relieved her pain for 9 months without muscle weakness. This case shows usefulness of radiofrequency lesion for obturator nerve pain.
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PMID:[Effective radiofrequency lesioning for obturator nerve neuropathy]. 1453 Dec 61

Although historically considered a diagnosis of exclusion, suprascapular neuropathy may be more common than once believed, as more recent reports are describing the condition as a cause of substantial pain and weakness in patients with and without concomitant shoulder pathology. The etiology is traction or compression of the suprascapular nerve. This can result from a space-occupying lesion, such as a ganglion cyst, or a traction injury as a result of repetitive overhead activities. More recent studies have cited cases of traction injuries occurring with retraction of a large rotator cuff tear. Atrophy of the infraspinatus and/or supraspinatus rotator cuff muscles with resultant weakness in forward flexion and/or external rotation of the shoulder on physical examination may be demonstrated. Magnetic resonance imaging (MRI) is the preferred modality to assess atrophy of the rotator cuff muscles as well as assess potential causes of suprascapular nerve compression. Electromyography and nerve conduction velocity studies remain the gold standard for confirmation of the diagnosis of suprascapular neuropathy; however, nerve pain may occur even in the setting of a negative electromyography. Initial management is usually nonoperative, consisting of activity modification, physical therapy, and nonsteroidal anti-inflammatory drugs. Surgical intervention is considered for patients with nerve compression by an external source or for symptoms refractory to conservative measures. Decompression of the suprascapular nerve may be accomplished through an open approach, although arthroscopic surgical approaches have become more common in the past several years.
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PMID:Suprascapular neuropathy: diagnosis and management. 2250 53

Overall complication rates of 9.1% have been reported following implantable cardioverter defibrillator (ICD) placement. Brachial plexus injury is infrequently reported in the literature. We describe a 26-year-old female experiencing left arm nerve pain, a positive Tinel's sign, numbness in the median nerve distribution of the hand and biceps muscle weakness following revision ICD via subclavian vein approach. Nerve conduction studies identified severe partial left brachial plexopathy, which remained incompletely resolved with conservative management. Surgical exploration revealed lateral cord impingement by the ICD generator and a loop of the ICD lead, along with fibrosis, necessitating surgical neurolysis and ICD generator repositioning. As increasing numbers of patients undergo cardiac device implantation, it is incumbent on practitioners to be aware of potential increases in the prevalence of this complication.
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PMID:Brachial plexus impingement secondary to implantable cardioverter defibrillator: A case report. 3101 32

Percutaneous treatments for trigeminal neuralgia (TN) include glycerol rhizotomy (GR), radiofrequency thermocoagulation (RF), and balloon compression (BC), which aim to provide pain relief by targeted injury to the trigeminal nerve pain fibers. All three techniques are well established and can provide immediate pain relief; however each of them can be associated with a range of complications. Our objective was to compare the safety and efficacy of GR, RF and BC in patients with TN. This study was performed according to the PRISMA guidelines. A random effects model meta-analysis was conducted. Fourteen studies were included. The comparisons of RF vs GR comprised 2,518 patients overall. RF was associated with statistically significant higher odds of immediate pain relief (OR: 2.65; 95% CI: 1.29-5.44; I 2:85.5%) when compared to GR. Patients in the RF group had a statistically significant higher risk of anesthesia in the trigeminal distribution (OR: 4.73; 95% CI: 2.25-9.96; I2:0%) and lower risk for herpes eruption (OR: 0.30; 95% CI: 0.17-0.56; I2 :0%). The comparison of BC vs GR included 961 patients. Patients in the BC group had a statistically significant higher risk of mastication weakness (OR: 9.29; 95% CI: 2.71-31.86; I2:0%) and diplopia due to CN IV or CN V palsy (OR: 6.31; 95% CI: 1.70-23.33; I2 :0%) compared to patients in the GR group. The comparisons of BC vs RF comprised 3,183 patients and did not show significant differences between the two groups. RF is associated with statistically significant higher odds for immediate pain relief and anesthesia and lower risk for post-operative herpes eruption as compared to GR. Patients in the BC group had a statistically significant higher risk to develop post-operative mastication weakness and diplopia when compared to GR.
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PMID:Comparative safety and efficacy of percutaneous approaches for the treatment of trigeminal neuralgia: A systematic review and meta-analysis. 3112 70