Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 14-yr-old male presented for medical clearance to play fall football for his high school team. He had stayed out of the prior spring football practice sessions after a shoulder injury on the first day of practice, but indicated no other positive responses to the standard medical questionnaire. He was severely overweight with height of 180 cm, weight 133.4 kg, and his estimated body fat was 36%. His examination was otherwise not revealing. He demonstrated poor aerobic fitness, exercise-induced bronchospasm, residual left shoulder weakness, and a dyslipoproteinemia on further medical evaluation. He was disqualified on an empirical basis, the attending physician making the clinical decision that it would be of greater harm than good for this adolescent to participate. However, there is little data and no established guidelines for this type of situation. The overweight football athlete is a challenge to the sports medicine team, both in managing the condition and in determining athletic eligibility.
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PMID:Obesity in a high school football candidate: a case presentation. 156 Jul 49

Cartilage-hair hypoplasia is an osteochondrodysplasia with short-limbed short stature. The cartilage-hair hypoplasia gene is exceptionally prevalent in Finland; more than 100 patients have been identified. We have analyzed the growth of 100 Finnish patients and present cartilage-hair hypoplasia-specific growth charts of height and weight for height. The disproportions were analyzed by sitting height, subischial leg height, sitting height:height ratio, and span-height difference. The stature was short at birth with a mean relative length of -3.0 SD. The median adult height was 131.1 cm (-7.9 SD, range 110.7 to 149.0 cm) for 15 males and 122.5 cm (-7.9 SD, range 103.7 to 137.4 cm) for 20 females. The progression of the growth failure was partly explained by weakness or absence of pubertal growth spurt. Weight for height was above normal median in childhood and increased further at puberty. Most of the adults were overweight. The adults' mean relative head circumference was -0.9 SD. Growth was disturbed both in the limbs and in the spine, more severely in the limbs. Adult height showed no correlation with the midparent height. The charts are useful for assessment of growth, prediction of adult height, detection of superimposed disorders, and evaluation of growth-accelerating therapy.
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PMID:Growth in cartilage-hair hypoplasia. 154 48

The concept that obesity is a risk to health was clearly identified in the works of Hippocrates and frequently over the ensuing centuries. Obesity was originally discussed as part of more general texts. Scholarly theses on this subject began to appear in the late 16th century with the first monographs published in the 18th century. The value of dietary restriction, increasing exercise and reducing the amount of sleep were identified early in medical history dating at least from the time of Hippocrates. These concepts were often framed in a manner which implied a 'moral' weakness on the part of the overweight individual. The most spectacular dietary success was published by a layman in 1863 and was the forerunner to many subsequent diet books. Cases of massive obesity were identified in stone age carvings and have been described frequently since the time of Galen and the Roman Empire. More specific types of obesity began to be identified in the 19th century. Following the identification of the cell as the basic building block of animals and plants, fat cells were described and the possibility that obesity was due to too many fat cells was suggested. After the introduction of the calorimeter by Lavoisier, the suggestion that obesity might represent a metabolic derangement has been suggested and tested. Standards for measuring body weight appeared in the 19th century. The possibility that familial factors might also be involved was clearly identified in the 18th and 19th century. In conclusion, most of the concepts which are currently the basis for research in the field of obesity had their origin in the 19th century and often earlier.
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PMID:Obesity: historical development of scientific and cultural ideas. 227 53

From the factors known to promote descensus those which may best be objectified--among them overweight, hard physical labour, weakness of the connective tissue and number of births--are examined in a group of women with descensus and a control group with regard to their valence for the development of a descensus. Log-linear models are applied in the calculation of qualitative variables. According to that, overweight means a fourfold, hard physical labour a threefold, weakness of the connective tissue a 2,7-fold and birth of more than one child a 2,2-fold risk of descensus.
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PMID:[Etiology of uterine prolapse]. 655 May 43

When the free TRAM flap was introduced for breast reconstruction, it was supposed to have many advantages over the pedicled TRAM flap: good perfusion of all four zones, better mobility and easier shaping of the breast, lower incidence of abdominal-wall complications, and less restrictive selection of patients. However, we have experienced several complications after free TRAM flaps in our practice, including fat necrosis, partial and complete flap necrosis, abdominal-wall weakness, and hernias. In order to evaluate the incidence and types of complications, as well as the influence of preoperative risk factors (chemotherapy, radiotherapy, overweight, smoking habits, and abdominal scars), on complications, a multicentric prospective study including Bern (Switzerland), Leuven (Belgium), Stuttgart (Germany), and Verona (Italy) was designed. In 111 consecutive patients, operated on over a period of 18 months, 123 flaps were done; 99 flaps were unilateral and 24 bilateral, and 36 were used for primary and 87 for late reconstruction. There was no preoperative selection of patients. The follow-up period was from 8 to 24 months (average 19 months). A two-team operating approach was used. All four zones were always included in the flap, and the end-to-end anastomoses were done to the thoracodorsal, the circumflex scapular, or the internal mammary arteries. The total number of fat and flap necroses was 24 (19.5 percent), 6 (5 percent) minor and 4 (3 percent) major fat necroses, 2 (1.6 percent) minor and 6 (5 percent) major flap necroses, and 6 (5 percent) total flap necroses. Twenty-two (20 percent) patients had abdominal-wall complications. The results of this study show that the complication rate of free TRAM flaps is considerable. Preoperative risk factors did not play a major role in the development of complications and should not be considered as contraindications for free TRAM flap surgery. All total flap failures resulted from impaired arterial inflow to the flap, and the choice of recipient vessel did not influence the outcome. The incidence of total flap failures might be reduced by good postoperative flap monitoring and early revision of the anastomosis. Partial fat and flap necroses might be prevented by removing the fat under the scarpa fascia in zones 4 and 3 or by reducing zone 4. Sparingly harvesting the rectus muscle and its sheath as well as the use of mesh in the rectus sheath repair may reduce the abdominal-wall complications.
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PMID:Late results of breast reconstruction with free TRAM flaps: a prospective multicentric study. 776 6

With the conventional method of fasting or aggressive dieting to reduce excess body fat, hunger, weakness, ketogenesis and ketosis are the sequential events that follow. It is not fully understood why, under conditions of negative calorie balance where complete energy release from storage fat is critical, ketosis should arise with a concomitant wastage of energy. Here, I wish to propose a theory that relates the formation of ketone bodies under such conditions to a deficiency in dietary pantothenic acid. Supplementation of this vitamin would facilitate complete catabolism of fatty acids and thus the formation of ketone bodies could be circumvented. As a result, a sufficient amount of energy would be released from storage fat to relieve dieters of the sensation of hunger and weakness which otherwise would be difficult to endure. Hence, using this method for weight reduction together with a careful observation of calorie intake, I have great success in treating overweight-to-obese patients to lose weight.
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PMID:Pantothenic acid as a weight-reducing agent: fasting without hunger, weakness and ketosis. 858 72

There is increasing concern that too much physical activity may lead to osteoarthritis. The continuous stress that physical activity places on the joints can result in microtrauma and degeneration of the articular cartilage. However, the onset of osteoarthritis appears to depend on the frequency, intensity and duration of physical activity. Research has shown that individuals of all ages can tolerate moderate amounts of exercise without adverse consequences or accelerated development of osteoarthritis. However, excessive participation in high impact sports, particularly over a long period of time and at an elite level, can increase the risk of developing osteoarthritis. Participants may also be at risk if they have abnormal joint anatomy or alignment, joint instability, underlying muscle weakness or imbalance, or if they are overweight and engage in significant amounts of exercise. Individuals who have experienced sports injuries to joints, or macrotrauma, may also be at risk of accelerated development of osteoarthritis. Certain types of surgery for the treatment of severe sports injuries, particularly to the knee, also appear to be associated with an increased risk. If surgery to the knee is required, continuous passive motion is an ideal form of rehabilitative treatment, as it promotes healing of the articular cartilage, ligaments and tendons. Moreover, athletes who have undergone surgery should return slowly to sporting activities to ensure they do not place too much stress on their injured joint(s). Further research into the causes of osteoarthritis is required; in particular, prospective and retrospective cohort studies are needed to confirm the association between exposure to risk factors and the development of osteoarthritis.
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PMID:Sports participation, sports injuries and osteoarthritis: implications for prevention. 1049 30

The aim of the study was to assess the clinical picture of patients with sleep apnea syndrome (SAS). The study group consisted of 54 patients (51 men, 3 women) mean age 49.7 +/- 8.7 years, mean body mass index (BMI) 33.1 +/- 5.8. In all cases polisomnography confirmed the diagnosis of SAS. Mean apnea and hypopnea index (AHI) was 66.6 +/- 30.7 and mean minimum arterial blood oxygen saturation was 67.57 +/- 11.58%. It allowed us to qualify 69.4% of patients to the group with a severe SAS. Snoring (93%), apneas (83%), excessive daytime sleepiness (80%), morning weakness (81%), nycturia (66%) were the most common symptoms. The most frequently accompanying diseases in patients with SAS were overweight (89%), depression (67%), arterial hypertension (51%), impaired glucose tolerance (41%).
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PMID:[Clinical picture in sleep apnea syndrome]. 1054 May 85

A 54-year-old black male with a 15-year history progressive lower extremity weakness was evaluated with a thoracic MRI that revealed epidural lipomatosis extending from T1-T10 with an associated syrinx at T1-3. He was neither overweight nor taking steroids. A multilevel thoracic laminectomy with resection of lipoma was performed without directly addressing the syrinx. Postoperatively, his symptoms improved and an MRI obtained 1 year after surgery demonstrated resolution of the syrinx. This is the only case of epidural lipomatosis with an associated syrinx that we have seen reported in the world literature.
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PMID:Thoracic epidural lipomatosis with associated syrinx: case report. 1094 Apr 29

Wasting is a severe, dangerous medical condition, and it can occur quickly, even in overweight patients. In wasting, the digestive process is disrupted, and patients lose their ability to absorb necessary nutrients from food. HIV interferes with metabolism, causing the body to burn muscle mass before it burns fat. Additionally, other physical problems can make eating difficult or painful, and the nausea associated with HIV therapies compounds the problem. Several nutritional supplements are recommended for people with weakness, fatigue, or poor appetite. Some are standard supplements intended to boost caloric intake easily, others are modified fat supplements or special formula supplements designed for special purposes.
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PMID:Managing weight loss with nutritional supplements. 1136 27


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