Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The symptoms in metastatic compression of the spinal cord or cauda equine are described after a systematic recording of the sequence of symptoms in 153 patients. Radicular pain was predominant in patients with metastases located in the lumbar area, while the severity of motor symptoms was positively correlated with thoracic metastases. The most common initial symptom was radicular pain, followed, with decreasing frequency, by motor weakness, sensory complaints and bladder dysfunction. The progression of motor weakness influenced the probability of establishing the diagnosis of spinal cord compression by stepwise marked increased probability when patients lost gait function or progressed into total paralysis.
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PMID:Symptoms and signs in metastatic spinal cord compression: a study of progression from first symptom until diagnosis in 153 patients. 820 66

A retrospective study was conducted on 21 consecutive patients with combined clinical and radiologic evidence of posttraumatic syringomyelia. Medical records and radiologic studies were reviewed to determine the following: age at injury, mechanism of trauma, spinal column injury and resultant neurologic deficit, latency period between injury and clinical manifestations of posttraumatic syringomyelia, clinicoradiologic findings of posttraumatic syringomyelia, and results of treatment. The patients were found uniformly to have sustained significant trauma (gunshot wounds, falls, or vehicular accidents) with marked neurologic dysfunction at the time of injury. Latent periods ranged from 1 month to 23 years. The most commonly presenting symptoms were radicular pain, spasticity, sensory loss, hyperhidrosis, and weakness. The most common physical findings were spasticity, hypesthesia, and weakness. Long term followup was obtained in 17 (81%) of the cases and suggested a higher rate of satisfaction among patients treated with surgical decompression of the syrinx. Radicular pain and sensory disturbance responded most predictably to surgical intervention, whereas spasticity responded least favorably. It is concluded that posttraumatic syringomyelia is a potentially disabling but treatable late complication of spinal injury, warranting a high index of suspicion among physicians who observe patients with such trauma.
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PMID:Posttraumatic syringomyelia: a review of 21 cases. 900 13

Eighty-four consecutive patients with posterolateral cervical disk herniation treated by keyhole foraminotomy between 1980 and 1987 were reviewed. Radicular pain was the most common presenting complaint. Weakness was present in 59 patients. Sixty patients were available for long-term follow up, averaging 6.1 years. Fifty-six patients' results were graded as excellent. Three patients had good results and one fair result was noted. There were no poor results. Preoperative pain symptoms were relieved in all patients. There were no significant complications. The posterolateral keyhole foraminotomy is an efficient means of decompressing lateral soft disk herniations, without the risk of an anterior approach or iliac crest bone harvest. Careful patient selection and use of an operative microscope are essential in obtaining consistent, excellent results.
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PMID:Cervical disk disease and the keyhole foraminotomy: proven efficacy at extended long-term follow up. 926 87

Spinal epidural abscesses are difficult to diagnose and are associated with high morbidity and mortality. A 61-year-old Chinese woman fell and was admitted 5 days later with constant epigastric pain and constipation. Clinical examination was initially normal. Five days after admission, she developed urinary retention and mild lower limb weakness, progressing overnight to paraplegia. Clinical examination was consistent with a thoracic myelopathy. Neuroimaging showed a paracentral fluid collection compressing the thoracic cord at T8 level. Emergent neurosurgical intervention revealed an epidural abscess, which was drained. She responded to a 9-week course of antibiotics and recovered fully. Radicular pain from thoracic pathology can mimic intraabdominal pathology, and a high index of suspicion and prompt surgical intervention are essential to avoid the potentially devastating consequences of delayed recognition of epidural abscesses.
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PMID:Abdominal pain from a thoracic epidural abscess. 1660 76

Osteoporotic vertebral fractures (OVFs) are the common disease found in elderly population. Neurological deficit in OVFs is rare despite the involved posterior cortex of the fractured vertebral body, severe kyphotic deformity, or the instability at the fracture site. OVF with resulting neurological deficit was considered as a contraindication for vertebral augmentation techniques. We reported a rare case of a 75-year-old woman with L1, L2 osteoporotic vertebral fractures and L5/S1 disc herniation who presented with back pain and radicular pain extending along the posterior aspect of the left leg. Physical examination showed slight weakness of her flexor hallucis longus and absence of ankle jerk on her left leg. The result of a straight leg-raising test was limited to an angle of 50 degrees. The radiographs showed that the nerve root was compressed by the retropulsed bone fragment of the L2 vertebral body and a herniated disc at the level of L5/S1 on the left side. After L1 and L2 kyphoplasty the radicular pain as well as the back pain was completely disappeared. At her two-year follow-up examination, the patient was completely symptom free and reported no radicular pain. This case suggested that minimally invasive techniques such as kyphoplasty or vertebroplasty are effective in certain OVF patients with neurological deficit. Radicular pain could be caused by osteoporotic fracture that involves the posterior cortex of the vertebral body. Understanding the anatomy of nerve roots and pathogenetic mechanism of radicular pain is particularly important for treatment option.
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PMID:Percutaneous kyphoplasty for the treatment of osteoporotic thoracolumbar fractures with neurological deficit: radicular pain can mimic disc herniation. 2523 37