Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mecamylamine (MCL) has been shown to extinguish nicotine dependence in rats and monkeys. MCL was administered to fourteen nicotine-dependent persons to determine if it may be effective in withdrawing nicotine-dependent humans at doses which have acceptable toxicity. Subjects smoked 20 to 60 cigarettes per day for a mean of 2.4 years, and none had been nicotine abstinent for as much as one day for at least one year. MCL was started in a dose of 5 to 10 mg per day and progressively raised until the subject experienced nicotine blockage and/or toxic effects. During MCL administration, 7 of 14 (50%) totally ceased smoking within the first 11 days of treatment, and an additional 4 (28.6%) subjects reduced cigarette consumption to less than five per day by the end of three weeks. Thirteen of 14 (92.9%) subjects stated that MCL blocks nicotine, reduces nicotine craving, and "works." At least some minor side-effects of MCL were observed in every subject. The most intolerable side-effects were constipation, urinary retention, abdominal cramps, and weakness, and these were responsible for drop-out of 5 (35.7%) subjects. Although there is a high prevalence of side-effects, MCL is probably a viable withdrawal treatment for some cases of recalcitrant nicotine dependence.
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PMID:Clinical evaluation of mecamylamine for withdrawal from nicotine dependence. 643 66

2 case reports are presented of IUN wearers with advanced actinomycotic disease. In both women there was extensive involvement of the bowel and in 1 woman deposits in the liver. The discussion covers the objectives of making a preoperative diagonsis, initiating antibiotic therapy, and potentially obviating or limiting surgical intervention. A 44-year old black woman complained of gradually increasing abdominal girth, weight loss, weakness, and pedal edema. Her last menstrual period had been 5 months prior to admission. She had an IUD in place for 11 years and was sexually inactive. She was a cachectic woman with a temperature of 100 degrees Farenheit, bilateral inguinal adenopathy, and 1+ pedal edema. Barium studies revealed an IUD in the right side of the pelvis and a large soft tissue mass pressing upon and intimately adherent to the sigmoid colon. At laparotomy, mumerous adhesions were encountered and a large cavitated mass was found to occupy the entire left side of the pelvis. Fistulas extended from it to both the sigmoid colon and the small bowel. Frozen sections revealed fibrosis and inflammaion with confluent granulomas. Gram stains of the exudate showed sulfur granules suggesting atinomycotic infection. A total hysterectomy and bilateral salpingo-oophorectomy were performed and the intestinal fistuals were repaired. Examination of the resected specimens showed a Majzlin Spring IUD imbeded in the endometrium and myometrium. In the immediate postoperative period, the patient was treated with high dose intravenous antibiotic therapy and on discharge she was continued on oral penicillin. The 2nd case, a previously healthy 53 year old white woman gave a 2 month history of intermittent lower adbominal pain, cramping and alternating diarrhea and constipation. Her last menstrual period had been 6 months earlier and she claimed to have forgotten about a Dalkon Shield IUD which had been in place for 20 years. AT laparotomy, a firm infiltrating mass was found to involve the uterus, left fallopian tube, sigmoid colon, and pelvic side walls. Gross pathologic examination demonstrated extensive acute and chronic inflammation and granulation of the left fallopian tube, uterus, and sigmoid colon. The sigmoid showed thickening of musculas layers, reactive fibrosis in the submucosa, subserosa, and mesentery, and areas of formation of small sinus tracts and/or abscesses. A single sulfur granule was found within the lumen of the left fallopian tube. Gram stain of this demonstrated the characteristic filamentous nature of actinomyces. After surgery, Cefoxitan was continued and intravenous penicillin was added. Both patients were postmenopausal and had forgotten about their IUDs. Millions of women with IUDs are know to be asymptomatic carriers of actinomycosis by virtue of the appearance of the bacillus on routine Pap smears. Most of these women are still menstruating. Possibly cyclical menstrual flow is something of a cleansing mechanism protecting these women from actinomycotic infection.
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PMID:Abdominal manifestations of actinomycosis in IUD users. 648 Nov 17

Fourteen patients with cauda equina syndrome secondary to long-standing ankylosing spondylitis are described. The roughly symmetrical neurological deficits were very slowly progressive and began long after the onset of the spondylitis, usually well after the rheumatological symptoms had stopped. Eventually every patient had cutaneous sensory loss in the fifth lumbar and sacral dermatomes. All patients developed urinary sphincter disturbances of a lower motor neuron type. There was prominent loss of rectal sphincter tone, and all but 2 patients had bowel complaints, including incontinence and severe constipation. Seven patients had mild to moderate weakness in the lumbosacral myotomes. Seven patients had pain in the rectum or lower limbs. Electromyographic abnormalities were consistent with multiple lumbosacral radiculopathies. Myelography and computed tomographic scanning of the lumbosacral spine showed characteristic enlargement of the caudal sac and dorsal arachnoid diverticula that had eroded the laminae and spinous processes. Recognition of this syndrome, coupled with computed tomographic scanning of the lower spinal canal, allows one to omit myelography, a procedure that is difficult because of the associated spine abnormalities. Surgical intervention should be avoided.
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PMID:Cauda equina syndrome secondary to long-standing ankylosing spondylitis. 665 Dec 50

Constipation characterized by straining at defecation has been reported in association with an anteriorly located, but otherwise "normal' anus, however its cause is not known. In this communication the pathogenesis of constipation has been discussed on the basis of clinical features and intraoperative findings seen in seven children with this syndrome. The primary cause of constipation lies in the congenital malformation of the mid-portion of the external sphincter and weakness of the corresponding segment of the anal canal.
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PMID:Mid-anal sphincteric malformation, cause of constipation in anterior perineal anus. 672 76

Skin infections, both bacterial and viral, are endemic in contact sports such as wrestling and rugby football. In this report, we describe four cases of extensive cutaneous herpes simplex virus in players on a rugby team. All players had a prodrome of fever, malaise, and anorexia with a weight loss of 3.6 to 9.0 kg. Two players experienced ocular lesions associated with cutaneous vesicular lesions of the face. A third player, who had herpetic lesions on his lower extremity, experienced paresthesias, weakness, and intermittent urinary retention and constipation. All infected players on the team were forwards or members of the "scrum," which suggests a field-acquired infection analogous to the herpetic infections seen in wrestlers (herpes gladiatorum). Considering the serious sequelae of recurrent herpes simplex keratitis, the traumatic skin lesions in rugby football players should be cultured for herpes virus, and infected individuals should be restricted from playing until crusted lesions have disappeared.
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PMID:Transmission of herpes simplex virus type 1 infection in rugby players. 673 50

Between 1977 and 1979, 12 cases of infant botulism were diagnosed in Utah, and 87 control patients (normal, nonbotulism neurologic disease, and nonbotulism systemic disease) were evaluated. Observations from these patients suggest an expanded clinical spectrum of infant botulism including asymptomatic carriers of organism; mild hypotonia and failure to thrive; typical cases with constipation, bulbar weakness, and hypotonia; and children with a picture compatible with sudden infant death syndrome. Clostridium botulinum was isolated from the stools of three normal control infants and nine control infants who had neurologic diseases that were clearly not infant botulism. These infants were termed "asymptomatic carriers" of the organism. The occurrence of the asymptomatic carrier state suggests that a diagnosis of infant botulism cannot be made on a basis of culture results alone, but must rest in historical documentation and physical confirmation of progressive bulbar and extremity weakness with ultimate complete resolution of symptoms and findings over a period of several months. A common set of environmental features characterizes the home environment of children with infant botulism and "asymptomatic carriers" and includes: nearby constructional or agricultural soil disruption, dusty and windy conditions, a high water table, and alkaline soil conditions.
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PMID:Infant botulism: clinical spectrum and epidemiology. 700 56

A case of moderately severe botulism was diagnosed in a 4 weeks old white female. Clostridium botulinum toxin was identified repeatedly in the infant's faeces by means of the mouse protection assay. Clostridium botulinum was isolated in pure culture from faecal material. Both the organism and the toxin were type B. The onset of illness was characterized by mild constipation, apathy, weak sucking and difficulty with swallowing. Incipient, probably aspiration, pneumonia was diagnosed at the same time. Further signs of botulism developed during hospitalization, viz. loss of head control, pooled oral secretion, weak cry, mild ptosis, reduced facial expression, generalized muscular weakness and reduced spontaneous activity. A nasogastric feeding tube was needed because the ability to suck and swallow was impaired. Immediately on admission of the infant to hospital emergency treatment was started with ampicillin, which was followed by penicillin injections. The infant recovered in 60 days. Subsequent medical examinations demonstrated that the recovery was complete and the development normal. The case represents the first instance of infant botulism detected on the European Continent.
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PMID:Infant botulism type B in central Europe. 703 93

50% of hospitalized medical emergency cases are cardiological and respiratory emergencies. Myocardial infarction, cardiogenic shock, ventricular arrhythmias and left ventricular failure often cause sudden death occurring within 1 or 2 hours. Therefore immediate management is necessary already in the prehospital phase of cardiovascular events. This does also apply for acute respiratory failure due to obstructive ventilatory disorders. Acute exacerbations of chronic obstructive pulmonary disease frequently are masked and may be misinterpreted as encephalopathy or alcohol withdrawal syndrome. Sedation may be dangerous. Also neuroglucopenic syndrome and hyperosmolar coma are occasionally interpreted wrongly. Thyrotoxic crisis, adrenal crisis and hypercalcemia are characterized by lethargy, mental disturbance and weakness, by dehydration, myopathy, nausea, constipation, diarrhea or tenesms or arrhythmias. In this situation of varied symptoms the most important action is to think of endocrine emergency, which may have multiple etiologies.
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PMID:[Cardiovascular emergencies--endocrine and metabolic crises. Practical hints for the physician in emergency service]. 711 36

We reviewed the clinical features of 99 cases of infant botulism reported to the Centers for Disease Control from states other than California for the period 1976 to 1980. There were no toxin-specific differences in the distribution of ages at onset or sex of the cases. For 76 (76%) patients for whom data were available the most common presenting symptoms were poor feeding (43%) and constipation (24%). Weak suck, poor head control, floppiness, weakness in extremities, difficulty swallowing, altered cry and constipation were reported in over three-fourths of the infants for whom data were available. Loss of facial expression, extraocular muscle paralysis, dilated pupils and depression of deep tendon reflexes occurred significantly more frequently among infants with type B botulism than among those with type A botulism. Ventilatory assistance was required for 61% of infants receiving aminoglycosides after the onset of weakness compared to only 26% of those infants not receiving aminoglycosides (P = 0.01). Infant botulism presents a characteristic clinical picture and should be suspected when an infant presents with weakness.
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PMID:Clinical characteristics of infant botulism in the United States: a study of the non-California cases. 714 27

Twenty-eight patients with disseminated malignant melanoma, who had failed prior therapy, were treated with aziridinylbenzoquinone (AZQ) administered on a 5-day I.V. schedule repeated every 4 weeks. The starting doses were 8 or 6 mg/m2/day x 5 days for good-and-poor-risk patients respectively. There were no complete or partial responses among 23 evaluable patients but four patients had stabilization of disease. The dose-limiting toxicity was thrombocytopenia. Other toxicities included weakness, nausea, vomiting, anorexia, dizziness, abdominal pain, and constipation. AZQ, given on a 5-day schedule, is ineffective in the treatment of patients with metastatic malignant melanoma.
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PMID:AZQ therapy in patients with disseminated malignant melanoma. 716 3


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