Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1762617 (weakness)
 37,932 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thyrotoxic periodic paralysis (TPP) is produced by a different metabolic disorder than familial periodic paralysis. In the familial disorder, a myopathic cause is well known, but although electromyography can be used to demonstrate the site of the lesion in TPP, such studies are rare in the medical literature and the results are conflicting. In this report, EMG studies were carried out on eight Chinese patients with thyrotoxic periodic paralysis during the attack and the results compared with studies repeated during a remission. Most cases showed a myopathic pattern during an attack of paralysis which disappeared during remission. The myopathic changes noted were a decrease in duration of muscle action potentials, an increase in polyphasic potentials, a satisfactory interference pattern with reduced amplitude and a reduced amplitude of the evoked muscle action potential on nerve stimulation. Peripheral nerve function was normal in the cases studied. It is concluded that the weakness in TPP is myopathic and that the peripheral nerve function during paralysis is normal.
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PMID:Electromyographic (EMG) study in thyrotoxic periodic paralysis. 27 70

Periodic paralyses are uncommon disorders characterized by episodic muscle weakness, often with hypokalemia. Thyrotoxic periodic paralysis (TPP) is the most common and is rarely seen in the Caucasian population; the relative unfamiliarity of TPP among physicians in the United States may lead to initial errors in diagnosis. This article presents the case of a 25-year-old white man with frequent episodes of skeletal muscle weakness and cramping, associated with profound hypokalemia. Laboratory evaluation demonstrated primary hyperthyroidism, and a diagnosis of TPP was made. The disorder is found more commonly in men between the ages of 20 and 40. Hypokalemia is the most consistent laboratory abnormality, representing a transcellular shift rather than a total body deficit; the exact mechanism is unknown. The exercise test demonstrates distinct electromyographical abnormalities in those with periodic paralysis. The definitive treatment of TPP is establishing a euthyroid state.
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PMID:Thyrotoxic periodic paralysis in a Caucasian man: recognition and diagnosis. 177 Feb 23

Thyrotoxic periodic paralysis occurs much more frequently in Orientals than in whites, and has rarely been reported in patients of Hispanic descent. A 28-year-old Mexican man presented with acute onset of bilateral lower extremity weakness after ingestion of a large carbohydrate meal. Laboratory investigation revealed severe hypokalemia, with a serum potassium level of 2.1 mmol/L (2.1 mEq/L), and hyperthyroidism. Administration of potassium chloride resulted in normalization of the serum potassium level and resolution of muscle weakness. Treatment with propranolol, and subsequent restoration of a euthyroid state with iodine 131, was effective in preventing further episodes of paralysis. Thyrotoxic periodic paralysis, although rare, may occur in Hispanic patients, and should be considered in the differential diagnosis of muscle weakness in this population.
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PMID:Thyrotoxic periodic paralysis in a hispanic man. 334 71

A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself.
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PMID:Thyrotoxic periodic paralysis. 394 49

Thyrotoxic periodic paralysis (TPP) is a disorder that affects a small percentage of patients with hyperthyroidism; the patients are predominantly Asian men. Two typical cases are presented here; both patients came to the emergency room with complaints of sudden onset of weakness. Their symptoms were initially resolved through treatment for acute hypokalemia. Additional tests identified the patients as being thyrotoxic for which condition they underwent thyroid ablation with radioiodine. No further episodes were reported for either patient. Often the underlying cause of the weakness or paralysis is undetected because of the absence of clinical symptoms of hyperthyroidism and because clinicians are unfamiliar with the disorder. It is imperative that TPP be recognized in the differential diagnosis of weakness and that the underlying thyrotoxicity is treated to permanently alleviate the condition. The authors discuss the epidemiology, etiology, clinical manifestations, and treatments of TPP.
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PMID:Thyrotoxic periodic paralysis: two case studies. 760 91

Thyrotoxic periodic paralysis (TPP) is an unusual complication of a fairly common disease affecting mostly Asian males. In the United States, there have been several reports of TPP in different ethnic populations and it appears that the incidence is approximately one-tenth of that found in Asian countries. Only six reports of TPP in African-Americans could be found in the literature; however, we are reporting four cases diagnosed within a 13-year period at our institution. We conclude that TPP may occur more often in Blacks than previously suspected and should be considered when patients present with unexplained hypokalemia, muscular weakness and rhabdomyolysis. The epidemiology, clinical manifestations, pathophysiology, and treatment of TPP are reviewed.
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PMID:Thyrotoxic hypokalemic periodic paralysis: report of four cases in black American males. 771 9

Thyrotoxic periodic paralysis (TPP) is an uncommon syndrome that can be fatal. We report the case of a patient with acute, severe muscle weakness and hypokalemia who was diagnosed in the emergency department to have thyrotoxicosis with acute TPP. The hypokalemia was treated aggressively with potassium without effect. After administration of i.v. propranolol, the patient had complete resolution of symptoms, with mild rebound hyperkalemia. The literature on the use of propranolol in TPP is reviewed, and the known pathophysiology of TPP is discussed.
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PMID:Thyrotoxic periodic paralysis terminated with intravenous propranolol. 809 4

Thyrotoxic periodic paralysis is a rare clinical manifestation of thyrotoxicosis in spanish population. Patients show weakness and frecuently, paralysis and low levels of potassium in serum. The episode can be triggered by eating high carbohydrate diet, exercise, stress and some drugs. We present a new case of thyrotoxic periodic paralysis in a Grave's disease patient. Only four cases have been reported in the spanish literature. We conclude that a functional evaluation of thyroid gland is necessary in thyrotoxic periodic paralysis patients.
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PMID:[Thyrotoxic periodic paralysis: an exceptional case report in Spanish population]. 867 5

A young Chinese American male presented with progressive proximal muscle weakness and inability to stand and walk. Investigations revealed marked hypokalemia and thyroid studies revealed hyperthyroidism consistent with Graves' disease. Thyrotoxic periodic paralysis is a rare disorder in the Western hemisphere, yet needs to be considered as a cause particularly in patients of Oriental origin presenting with sudden weakness. The case history and update of current knowledge of thyrotoxic periodic paralysis is presented.
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PMID:Thyrotoxic periodic paralysis; a reversible cause of paralysis to remember. 936 Apr 42

Hypokalemic periodic paralysis occurring in thyrotoxicosis is rare in Caucasians and is not often highlighted as an endocrine emergency. Periodic paralysis, without familial background, manifests only in the thyrotoxic patient. Thyrotoxic periodic paralysis is a self-limiting disorder that is cured by the treatment of the underlying hyperthyroidism. We report an unusual case of acute onset weakness from thyrotoxic periodic paralysis in a young Chinese migrant who had a normal serum potassium level at the time of initial presentation, though on subsequent presentation one week later, he had the typically associated hypokalemia. We also review the literature on thyrotoxic periodic paralysis.
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PMID:Thyrotoxic periodic paralysis: a case report and review of the literature. 995 Mar 86


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