Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1658953 (
tumor vasculature
)
2,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Erythropoietin
(
EPO
) stimulates the growth of erythroblasts in the bone marrow (C. Lacombe and P. Mayeux, NEPHROL: DIAL: TRANSPLANT:, 14 (SUPPL: 2): 22-28, 1999). We report basal and hypoxia-stimulated expression of
EPO
and its receptor, EPOR, in human breast cancer cells, and we demonstrate
EPO
-stimulated tyrosine phosphorylation and the proliferation of these cells in vitro. In 50 clinical specimens of breast carcinoma, we report high levels of
EPO
and EPOR associated with malignant cells and
tumor vasculature
but not with normal breast, benign papilloma, or fibrocystic tissue. Hypoxic tumor regions display the highest levels of
EPO
and EPOR expression. Enhanced
EPO
signaling may contribute to the promotion of human cancer by tissue hypoxia.
...
PMID:Erythropoietin and erythropoietin receptor expression in human cancer. 1132 18
