Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Transmembrane protein 45B
(
TMEM45B
), belonging to the TMEM family, has been found abnormally expressed in several types of tumors and can play an important role in tumorigenesis. However, the role of
TMEM45B
in gastric cancer remains unclear. Therefore, the current study was designed to examine the effects of
TMEM45B
on gastric cancer cell proliferation, migration and invasion in vitro, and to explore the potential molecular mechanisms. The presented study is the first demonstration that
TMEM45B
was highly expressed in human gastric cancer tissues and cell lines. In addition, knockdown of
TMEM45B
significantly inhibited cell proliferation, migration/invasion and
EMT
phenotype in gastric cancer cells. Furthermore, knockdown of
TMEM45B
efficiently inhibited the expression of p-JAK2 and p-STAT3 in gastric cancer cells. Taken together, our findings indicate that knockdown of
TMEM45B
suppresses the proliferation, migration and invasion of gastric cancer cells, at least partly, via the inhibition of JAK2/STAT3 signaling pathway. Therefore,
TMEM45B
may be a new potent therapeutic molecule for the treatment of gastric cancer.
...
PMID:Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. 2980 69
