Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. Our previous study has shown that
MRTF-A
promote the migration of MDA-MB-231 cells and WDR1 promotes breast cancer cell migration. But the exact molecular mechanism on metastasis is still not fully understood, we now report that WDR1 enhanced the effect of
MRTF-A
induced-MDA-MB-231 cell migration by promoting the expression of the
EMT
markers and migration markers via RhoA-
MRTF-A
signaling pathway. Importantly, WDR1 promoted the nuclear importion of
MRTF-A
by affecting the expression of nuclear transport protein importin. But WDR1 did not affect the expression of
MRTF-A
. Interestingly,
MRTF-A
promoted the expression of miR-206 via its promoter CArG box but miR-206 inhibits the migration of breast cancer cells through suppressing the expression of WDR1 and
MRTF-A
via targeted their 3'UTR. Our data thus provide important and novel insights into
MRTF-A
-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.
...
PMID:MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration. 2882 8
