Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TMPRSS3
belongs to the large type II transmembrane serine protease (TTSP) family, which plays an important role in the development and progression of tumors. However, the function of
TMPRSS3
in nasopharyngeal carcinoma (NPC) remains unclear. The present study aimed to examine the impact of
TMPRSS3
on the proliferation, migration, and invasion of NPC cells and their potential mechanisms. Our results demonstrated that the expression of
TMPRSS3
was obviously upregulated in human NPC tissues and cell lines. Knockdown of
TMPRSS3
expression significantly suppressed the proliferation and tumorigenicity of NPC cells in vitro and in vivo. Furthermore, knockdown of
TMPRSS3
inhibited migration and invasion, as well as prevented the
EMT
process in NPC cells. Finally, knockdown of
TMPRSS3
attenuated activation of the PI3K/Akt signaling pathway in NPC cells. Taken together, the present study demonstrates that the knockdown of
TMPRSS3
inhibits proliferation, migration, and invasion in human NPC cells through the inactivation of the PI3K/Akt signaling pathway. This study suggests that
TMPRSS3
may be a potential therapeutic target for the treatment of NPC.
...
PMID:Knockdown of TMPRSS3, a Transmembrane Serine Protease, Inhibits Proliferation, Migration, and Invasion in Human Nasopharyngeal Carcinoma Cells. 2840 56
