Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1522282 (EMT)
 2,868 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To identify the prevalence of serologic markers of hepatitis B and hepatitis C among rural prehospital providers, a prospective descriptive study was conducted of a rural county emergency medical services (EMS) system. Participants included 107 prehospital care providers: 102 EMT-Bs, 1 paramedic, and 4 law enforcement first responders. Blood samples taken from prehospital care providers were tested for hepatitis B surface antigen (HBsAg), antibody to HBsAg (HBsAb), antibody to hepatitis B core antigen (HBcAb), and antibody to hepatitis C (anti-HC). The 107 providers had a total of 635 years of EMS experience (5.93 years per subject). Three providers (3%) had received previous blood transfusions, 7 (7%) had worked in a metropolitan area, and 6 (6%) had multiple sexual partners prior to the study. No provider reported intravenous drug use or known homosexual or bisexual contact. Only one sample tested positive for hepatitis C antibody (anti-HC) and hepatitis surface antibody (HBsAb). Rural prehospital care personnel have a low prevalence (0.9%) of exposure to hepatitis B and hepatitis C. Despite this fact, continued vigilance should be maintained in preventing transmission of bloodborne illnesses.
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PMID:Seroprevalence of hepatitis B and hepatitis C among rural emergency medical care personnel. 914 78

Flotillin-2 (Flot2) is a highly conserved and ubiquitously expressed protein that resides on the cytoplasmic side of the cell membrane within specific cholesterol rich microdomains. Some studies have reported that overexpression of Flot2 is related to cancer progression. However, the role of Flot2 in hepatocellular carcinoma (HCC) remains unclarified. In this study, we aim to explore the correlation between Flot2 expression and HCC progression and the underlying mechanism. In the present study, overexpression of Flot2 in HCC tissues and cell lines was detected, and forced overexpression of Flot2 significantly promoted the proliferation, migration, invasion and metastasis of HCC in vitro and in vivo by modulating cell cycle and inducing EMT, which was mediated via up-regulation of Twist as a result of Raf/MEK/ERK1/2 pathway activation. In contrast, silencing Flot2 expression inhibited these biological processes. Furthermore, high expression of Flot2 was significantly correlated with poor prognosis of HCC patients after curative resection and is an independent risk factor. In conclusion, Flot2 promoted tumor growth and metastasis of HCC through modulating cell cycle and inducing EMT. The expression of Flot2 may play a key role in HCC progression and may be regarded as a potential poor prognostic marker for HCC.
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PMID:Flot2 promotes tumor growth and metastasis through modulating cell cycle and inducing epithelial-mesenchymal transition of hepatocellular carcinoma. 2856 58