Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recently,
RASAL2
has been found to function as a tumor and metastasis suppressor.
RASAL2
inhibited tumor growth, progression, and metastasis in several cancers. However, the regulatory effect of
RASAL2
in NPC still remains unclear. The purpose of this paper was to identify the role of
RASAL2
in the metastasis of NPC. The expression of
RASAL2
in human NPC was obviously down-regulated by real-time PCR analysis. Furthermore, knock-down of
RASAL2
with siRNA treatment resulted in a promotion of cell proliferation and migration in vitro. Additionally, transwell analysis results revealed that the number of invasion cells was increased of cells treated with
RASAL2
siRNA. We further explored the mechanism and demonstrated that the down-regulated
RASAL2
promoted migration and invasion via
EMT
induction with E-cadherin decreased expression and vimentin, N-cadherin, and Snail increased expression in NPC cells.In conclusion,
RASAL2
inhibited the proliferation and metastasis capability of NPC cells.
...
PMID:RASAL2 inhibited the proliferation and metastasis capability of nasopharyngeal carcinoma. 2677 Apr 93
