Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
While conventional MAP kinase pathways are one of the most highly studied signal transduction molecules, less is known about the
MEK5
signaling pathway. This pathway has been shown to play a role in normal cell growth cycles, survival and differentiation. The
MEK5
pathway is also believed to mediate the effects of a number of oncogenes.
MEK5
is the upstream activator of ERK5 in many epithelial cells. Activation of the MEK-MAPK pathway is a frequent event in malignant tumor formation and contributes to chemoresistance and anti-apoptotic signaling. This pathway may be involved in a number of more aggressive, metastatic varieties of cancer due to its role in cell survival, proliferation and
EMT
transitioning. Further study of this pathway may lead to new prognostic factors and new drug targets to combat more aggressive forms of cancer.
...
PMID:MEK5/ERK5 pathway: the first fifteen years. 2202 Feb 94
