Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522282 (
EMT
)
2,868
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aim:
Few studies focused on functions and regulatory networks of
MUC
family members in colorectal cancer based on comprehensive analysis of online database.
Materials & methods:
Copy number variation, methylation, pathway analysis and drug influence on
MUC
expression were analyzed based on The Cancer Genome Atlas and GTEx database.
Results:
Copy number variation analysis showed
MUC
heterozygous amplification and heterozygous deletion predominate. Methylation of
MUC17
,
MUC12
and
MUC4
were found related to gene expression. Function of MUC family genes mainly affects pathways such as apoptosis, cell cycle, DNA damage and
EMT
pathways. PLX4720, dabrafenib, gefitinib, afatinib and austocystin D can alter the expression of
MUC
gene.
Conclusion:
The genetic and epigenetic changes of
MUC
are related to the level of
MUC
expression in colorectal cancer.
...
PMID:Analysis of TGCA data reveals genetic and epigenetic changes and biological function of
MUC
family genes in colorectal cancer. 3177 91
