Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1522084 (Osteosarcoma)
 2,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
osteosarcoma 1448
Mol 175
Sep 120
p53 117
HOS 96
caspase-3 91
catenin 76
AKT 72
PI3K 68
Bcl-2 50
mTOR 46
osteogenic 39
matrix metalloproteinase 38
alkaline phosphatase 38
MMP-2 37
p21 35
UTR 34
E-cadherin 34
ERK 34
MAPK 33
MMP-9 33
p38 31
PARP 30
pRb 30
STAT3 27
kit 26
cyclin D1 26
collagen 26
MMP9 26
ERK1 25
VEGF 24
CCK 24
JNK 24
vascular endothelial growth factor 24
caspase-9 23
MEK 22
cytokine 22
vimentin 21
annexin V 21
AS1 20
RUNX2 20
osteocalcin 20
c-Myc 17
CXCR4 17
c-Jun 16
proteasome 16
MDM2 16
fibronectin 16
epidermal growth factor receptor 16
proliferating cell nuclear antigen 16
ROS 16
phosphatidylinositol 3-kinase 15
Cyclin D1 15
MMP2 15
N-cadherin 14
chemokine 13
PTEN 13
Rho 13
MYC 13
osteopontin 13
p65 13
endoplasmic reticulum 13
scratch 12
insulin 12
EGFR 12
MRI 12
RB1 12
Vimentin 12
rhabdomyosarcoma 12
RhoA 11
caspase-8 11
AP-1 11
Ki-67 11
TNF 11
p27 11
ezrin 11
c-myc 11
RANKL 11
phosphatase 10
protein kinase B 10
mitogen-activated protein 10
signal transducer and activator of transcription 3 10
survivin 10
histone 10
homeobox 10
insulin-like growth factor 10
RANK 10
Fas 10
tumor necrosis factor 10
TNM 10
She 9
Li-Fraumeni syndrome 9
metalloproteinase 9
GSK 9
CDK4 9
EMT 9
ZEB1 9
CXCL12 9
extracellular signal-regulated kinase 9
CCK8 9
cytochrome c 9
phosphatase and tensin homolog 9
Ezrin 9
LC3 8
Nanog 8
matrix metalloproteinase 2 8
cyclin 8
IL-6 8
FOS 8
tyrosine kinase 8
GSH 8
DDP 8
E2F1 8
bone morphogenetic protein 8
YAP 7
STAT 7
Mcl-1 7
PD-1 7
CD133 7
cyclin B1 7
helicase 7
Met 7
cage 7
tumour suppressor 7
COX-2 7
interferon 7
RECQL4 7
FAK 7
GTPase 7
ATP 6
histone deacetylase 6
ALP 6
phosphoinositide 3-kinase 6
IL-8 6
proto-oncogene 6
osteoprotegerin 6
osteonectin 6
SOX2 6
MET 6
MMP 6
Cyclin 6
zinc finger 6
ubiquitin 6
cadherin 6
interleukin-6 6
beta-catenin 6
CCND2 6
cyclin-dependent kinase 6
PEG 6
K12 6
OCT4 6
CD44 6
cyclin E 6
CDK6 6
MEG3 5
MTS 5
intercellular adhesion molecule-1 5
P-glycoprotein 5
threonine 5
APC 5
more...
Disease
osteosarcoma 2200
Osteosarcoma 2200
Osteosarcoma 2200
tumor 1321
cancer 1155
metastases 323
bone cancer 207
tumor growth 158
tumorigenesis 137
sarcoma 108
HOS 96
primary tumor 83
tumor progression 79
metastatic osteosarcoma 62
Ewing's sarcoma 61
lung metastases 59
chondrosarcoma 45
carcinogenesis 38
carcinoma 31
aggressiveness 31
retinoblastoma 28
Sarcoma 25
Sarcoma 25
osteoblastic osteosarcoma 23
AS1 20
bone neoplasm 19
leukemia 18
dysplasia 17
chondroblastic osteosarcoma 15
multiple myeloma 14
bone metastases 14
rare disease 14
childhood cancer 13
DDP 13
rhabdomyosarcoma 13
breast cancer 13
aggression 12
Chondrosarcoma 12
Chondrosarcoma 12
PDB 12
B-cell lymphoma 11
tumor initiation 11
pathological fracture 10
osteoporosis 10
bone disease 10
fibrosarcoma 10
localized osteosarcoma 10
Li-Fraumeni syndrome 10
colon cancer 9
melanoma 9
malignant fibrous histiocytoma 9
prostate cancer 9
solid tumor 9
EMT 9
osteoma 8
recurrent osteosarcoma 8
GSH 8
neuroblastoma 8
osteochondroma 8
fibroma 7
RTS 7
lymphoma 7
epiphysis 7
cold 6
fibroblastic osteosarcoma 6
ovarian cancer 6
Blocking 6
WT1 6
SCID 6
non-small cell lung cancer 6
infectious diseases 6
ATM 5
telangiectatic osteosarcoma 5
MTS 5
APC 5
adenocarcinoma 5
hepatocellular carcinoma 4
Still 4
Fibrous dysplasia 4
Hodgkin's disease 4
angiosarcoma 4
chondroma 4
familial cancer 4
intussusception 4
tumor angiogenesis 4
heart failure 4
periosteum 4
renal cell carcinoma 4
Infection 4
acute lymphoblastic leukemia 4
BLM 3
sepsis 3
osteogenesis imperfecta 3
residual disease 3
TEM 3
WRN 3
arthrodesis 3
chordoma 3
TEM 3
colorectal cancer 3
chloroma 3
Rhabdomyosarcoma 3
bowel obstruction 3
glioma 3
second cancer 3
liposarcoma 3
SDS 3
squamous cell carcinoma 3
Giant cell tumor 3
suicide 3
thyroid cancer 3
benign tumor 3
pancreatic cancer 3
systemic disease 3
Extraskeletal osteosarcoma 3
HCG 3
genetic disorder 2
tumor vasculature 2
Adhesion 2
teratoma 2
HSP 2
primitive neuroectodermal tumor 2
chronic pain 2
invasive cancer 2
myositis 2
Colon 2
leiomyosarcoma 2
synovial sarcoma 2
proptosis 2
Melanoma 2
myelodysplastic syndrome 2
hemangiopericytoma 2
hemangioma 2
hemangiosarcoma 2
minimal residual disease 2
gastric cancer 2
PNET 2
NOD 2
NF2 2
obstructive sleep apnea 2
Colon 2
hemangioendothelioma 2
DBA 2
Bone sarcomas 2
cervical cancer 2
DSS 2
tuberculosis 2
ICP 2
liver cancer 2
coronary artery disease 2
cancer recurrence 2
lung cancer 2
periostitis 2
medulloblastoma 2
schwannoma 2
neurofibromatosis 2
liver cancer 2
optic atrophy 2
RP11 2
sepsis 2
more...
Symptom
pain 39
anesthesia 5
dyspnea 5
bone pain 5
cancer pain 4
headache 4
distraction 4
diarrhea 3
starvation 3
low back pain 2
vomiting 2
thigh pain 2
leg pain 1
agitation 1
paresis 1
cough 1
regurgitation 1
cyanosis 1
fatigue 1
hip pain 1
nausea 1
knee pain 1
Scratch 1
dry skin 1
abdominal pain 1
discomfort 1
heel pain 1
numbness 1
functional recovery 1
nausea and vomiting 1
discomfort 1
chest pain 1
Spots 1
neck pain 1
collapse 1
hypothermia 1
syncope 1
seizures 1
dysuria 1
Drug
Monit 23
ROS 16
Adriamycin 8
GEO 7
Etoposide 4
ROC 4
lysine 4
NVP 4
ADM 3
2-Methoxyestradiol 3
Zoledronic acid 3
Auranofin 2
ADR 2
MAP 2
Cardiovasc 2
Denosumab 2
ABC 2
uPA 2
Zoledronic acid 2
Indomethacin 2
ETS 2
IL-11 2
Simvastatin 2
Mifamurtide 2
CSF 2
Gleevec 2
caffeine 2
CDP 2
Kenyan 1
G-CSF 1
Valproic Acid 1
Zein 1
Dermatol 1
Leucovorin 1
CTX 1
MRC 1
Arsenic trioxide 1
Cetuximab 1
Propidium 1
Molgramostim 1
BLM 1
Filgrastim 1
EHDP 1
Docetaxel 1
PFT 1
IL-1ra 1
Filgrastim 1
TiO2 1
Doxycycline 1
CTX 1
CTX 1
ACT 1
ascorbate 1
Fluorescein 1
IFN-gamma 1
Sorafenib 1
Alliance 1
Bestatin 1
Tranilast 1
Activin 1
Gelatin 1
Imatinib 1
Trabectedin 1
PDL 1
Everolimus 1
Anakinra 1
Cilengitide 1
Fluorescein 1
Hydroxypropyl cellulose 1
HCH 1
Bortezomib 1
Aprepitant 1
ALA 1
Enzyme
luciferase 121
mitogen-activated protein kinase 92
ERK 81
caspase-3 74
alkaline phosphatase 38
focal adhesion kinase 36
protein kinase 34
PARP 30
MEK 25
proteasome 16
caspase-9 16
phosphatidylinositol 3-kinase 15
caspase-8 11
GSK 10
protein kinase C 8
AMP-activated protein kinase 8
matrix metalloproteinase 2 8
MMP 7
lactate dehydrogenase 7
phosphoinositide 3-kinase 6
collagenase 6
cdc2 6
APC 5
P-glycoprotein 5
matrix metalloproteinase 9 5
AMPK 4
topoisomerase 4
topoisomerase 4
adenylate cyclase 4
AMPK 4
acid phosphatase 3
RNA polymerase 3
aldehyde dehydrogenase 3
aldehyde dehydrogenase 3
prostaglandin synthetase 3
urokinase-type plasminogen activator 3
trypsin 3
MMP-3 3
complex I 3
MEKK1 3
thymidine kinase 3
aldehyde dehydrogenase 3
aldehyde dehydrogenase 3
reverse transcriptase 3
MDP 3
calcineurin 3
ACS 3
5'-nucleotidase 3
ATPase 3
aldehyde dehydrogenase 3
alanine aminotransferase 2
protein phosphatase 2A 2
thrombin 2
cathepsin K 2
endonuclease 2
granzyme B 2
phospholipase C 2
firefly luciferase 2
CaMKII 2
PDK1 2
ornithine decarboxylase 2
HSD 2
polo-like kinase 1 2
aspartate aminotransferase 2
phosphatidylinositol-4,5-bisphosphate 3-kinase 2
MAP 2
dihydrofolate reductase 2
transcriptase 2
glutathione S-transferase 2
DNA methyltransferase 2
superoxide dismutase 2
glyceraldehyde-3-phosphate dehydrogenase 1
glyceraldehyde-3-phosphate dehydrogenase 1
kinesin 1
chitinase 1
methionine adenosyltransferase 1
MCS 1
AST 1
GLO 1
beta-glucuronidase 1
phosphorylase 1
prostate-specific membrane antigen 1
cathepsin D 1
IKK 1
O-GlcNAc transferase 1
diaphorase 1
ALDH 1
hexokinase 1
enterokinase 1
KLK7 1
glyceraldehyde-3-phosphate dehydrogenase 1
caspase-6 1
cathepsin F 1
nicotinamide mononucleotide adenylyltransferase 1
glutathione reductase 1
glyceraldehyde-3-phosphate dehydrogenase 1
catalase 1
peroxidase 1
thioredoxin reductase 1
glutathione peroxidase 1
inositol 3-kinase 1
lysozyme 1
CD13 1
glyceraldehyde-3-phosphate dehydrogenase 1
11beta-hydroxysteroid dehydrogenase 1
lipoxygenase 1
stromelysin-3 1
branched-chain aminotransferase 1
chymotrypsin 1
transglutaminase 1
kallikrein 1
cathepsin B 1
ornithine aminotransferase 1
CYP3A4 1
caspase-6 1
Protein 2 1
alginate lyase 1
caspase-1 1
CPR 1
demethylase 1
bromelain 1
STR 1
Compound
Dec 151
DNA 122
Clin 113
MTT 85
oxygen 58
calcium 36
bromide 24
MNNG 23
DDP 22
MEK 21
Adriamycin 18
phosphate 14
methionine 13
ADR 12
Vimentin 12
TNF 11
serine 10
Pac 10
nitrogen 10
TNM 10
tyrosine 10
glucose 9
PEG 8
GSH 8
iodine 8
GSH 8
PEG 7
threonine 7
cysteine 7
Methotrexate 7
ATP 6
N-acetylcysteine 6
Insulin 6
ALP 6
formaldehyde 6
boron 5
MTS 5
lysine 5
sodium 5
ASA 5
Celastrol 4
ADP-ribose 4
water 4
retinoic acid 4
selenium 4
titanium 4
PGE2 4
Ifosfamide 4
VP-16 4
ethyl acetate 4
celastrol 4
Panam 4
MTX 4
carbonate 4
GTP 4
Cyt 3
Lactate 3
TOF 3
potassium 3
Gemcitabine 3
2-Methoxyestradiol 3
adenosylmethionine 3
Cytochrome c 3
His 3
Triptolide 3
strontium 3
PPI 3
fluorine 3
Curcumin 3
Evodiamine 3
phosphorus 3
isoquinoline 3
Calycosin 3
ACS 3
iron 3
ACS 3
leucine 3
NAD 3
NAD 3
dUTP 3
tryptophan 3
Evodiamine 3
Melatonin 3
TEM 3
Gemcitabine 3
SDS 3
ethanol 3
Raddeanin A 3
EDTA 2
Phe 2
CDP 2
AMP 2
pyrimidine 2
MAP 2
Hoechst 33342 2
ammonium 2
Neo 2
silver 2
Sulforaphane 2
Punicalagin 2
Alginate 2
caffeine 2
Oridonin 2
EDTA 2
CAN 2
Fisetin 2
pyrimidine 2
vitamin D 2
DMSO 2
N6-Methyladenosine 2
formaldehyde 2
aspartic acid 2
chalcone 2
Amide 2
acetate 2
Rapamycin 2
Indomethacin 2
ADP 2
D-Serine 2
DPPH 2
arginine 2
Mg2+ 2
Baicalein 2
nonyl 2
zinc 2
urea 2
Asp 2
ADP 2
acridine 2
ADP 2
Quercetin 2
APAP 2
Paclitaxel 2
MDA 2
glutamine 2
Dexamethasone 2
cAMP 2
PDT 2
Adrenal 1
Sennoside A 1
INN 1
prostacyclin 1
Vitamin D 1
Gly 1
Euxanthone 1
CTX 1
Doxycycline 1
Serine 1
Pimozide 1
RELA 1
Cucurbitacin B 1
aspartic acid 1
GSSG 1
Plumbagin 1
quinazoline 1
Honokiol 1
naphthoquinone 1
THP 1
creatinine 1
Ether 1
more...