Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522084 (
Osteosarcoma
)
2,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Osteosarcoma
(OS) is the most commonly diagnosed primary malignancy affecting the bone.
UbcH10
is a cancer-related E2-ubiquitin-conjugating enzyme. An overexpression of
UbcH10
is significantly associated with tumor grade and cellular proliferation. However, limited evidence exists with regard to the biological function of
UbcH10
in OS. The present study created a
UbcH10
knockdown OS cell line using lentivirus-mediated RNA interference. The expression of
UbcH10
was significantly reduced in
UbcH10
-targeted small hairpin RNA-expressing lentivirus OS cells. The downregulation of
UbcH10
suppressed OS cell proliferation and colony formation ability via decreased Ki-67 expression.
UbcH10
knockdown OS cells exhibited impaired invasion and migration abilities. Furthermore, knockdown of
UbcH10
led to decreased levels of matrix metalloproteinase-3 and -9 in OS cells. The present study demonstrated the role of
UbcH10
in OS cell proliferation, invasion and migration, which suggests that
UbcH10
may be a potential candidate for OS therapy.
...
PMID:Lentivirus-mediated RNA interference targeting UbcH10 reduces cell growth and invasion of human osteosarcoma cells via inhibition of Ki-67 and matrix metalloproteinases. 2613 34
