Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1522083 (Osteosarcoma)
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Human Gene/Protein
KIAA0427 13.8
deleted in lung and esophageal cancer protein 1 13.8
HIST1H2AI 13.8
SRGAP2 protein 12.8
EIF4G2 protein 12.8
C3orf35 12.8
wingless-type MMTV integration site family, member 5B 12.8
ANKMY1 12.8
transmembrane protein 35 12.8
FAM45A 12.8
VMO1 12.8
ZNF343 12.2
KRTAP10-1 12.2
mitogen-activated protein kinase kinase kinase 9 12.2
kin of IRRE like 12.2
GTF2A2 12.2
SNRNP25 12.2
PRPSAP2 11.8
KRTCAP3 11.8
LCRMP 11.8
receptor (TNFRSF)-interacting serine-threonine kinase 1 11.8
brain-specific angiogenesis inhibitor 2 11.8
TP53RK 11.7
FATE1 11.5
WW domain-containing protein 1 11.5
Actin-like protein 11.5
ARPC5L 11.2
Ribosomal protein S9 11.2
ZNRF2 11.2
distal-less homeobox 6 11.0
Neurensin-2 11.0
LIN28B protein 11.0
Receptor tyrosine kinase-like orphan receptor 2 11.0
BTNL9 11.0
BZW1 11.0
MMS19L 11.0
Cytoskeleton-associated protein 2 11.0
SEZ-6 11.0
cerebellin 4 11.0
phosphatase and tensin homolog pseudogene 1 10.8
more...
Disease
Osteosarcoma 13.8
Osteosarcoma 13.8
dermoid inclusion 11.5
bone cancer 11.5
localized osteosarcoma 11.4
metastatic osteosarcoma 11.4
recurrent osteosarcoma 11.3
Cardiac neoplasms 11.2
Intracortical osteosarcoma 11.2
chondroblastic osteosarcoma 11.0
fibroblastic osteosarcoma 10.9
osteosarcoma 10.9
osteoblastic osteosarcoma 10.6
Malignant Peripheral Nerve Sheath Tumor 10.5
Periosteal chondrosarcoma 10.4
HOS 10.3
bone neoplasm 10.2
anaplastic osteosarcoma 10.0
Small cell osteosarcoma 9.8
Undifferentiated sarcoma 9.8
telangiectatic osteosarcoma 9.8
Medullary Thyroid Carcinoma 9.3
skeletal neoplasm 9.2
Chloroma 8.9
Extraskeletal osteosarcoma 8.8
Chondrosarcoma 8.6
Chondrosarcoma 8.6
Parosteal osteosarcoma 8.5
Hand-Schuller-Christian disease 8.3
Fibrous dysplasia of bone 8.2
Spermatic cord 8.2
congenital amegakaryocytic thrombocytopenia 8.1
Bone sarcomas 8.0
carcinoma of unknown origin 7.7
Sarcoma 7.6
Sarcoma 7.6
Ewing's sarcoma 7.5
lung metastases 7.3
AS1 7.3
Fibrous dysplasia 7.3
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Symptom
thigh pain 5.4
Scratch 5.2
Spots 5.0
heel pain 4.9
bone pain 4.5
cancer pain 4.2
dry skin 3.8
hip pain 3.0
leg pain 2.8
distraction 2.6
dysuria 2.6
knee pain 2.4
cyanosis 1.9
neck pain 1.9
low back pain 1.5
numbness 1.5
dyspnea 1.4
paresis 1.3
pain 1.1
regurgitation 0.8
starvation 0.8
syncope 0.6
nausea and vomiting 0.6
agitation 0.3
functional recovery 0.1
headache 0.0
vomiting -0.1
chest pain -0.3
hypothermia -0.3
diarrhea -0.4
anesthesia -0.6
discomfort -0.6
nausea -0.7
cough -0.7
discomfort -0.8
collapse -1.0
abdominal pain -1.1
fatigue -1.8
seizures -2.5
Drug
Mifamurtide 11.5
Molgramostim 11.2
2-Methoxyestradiol 8.0
Hydroxypropyl cellulose 8.0
Cilengitide 7.7
Valproic Acid 7.3
Trabectedin 6.6
Aprepitant 6.6
Auranofin 6.4
Tranilast 6.1
GEO 6.0
NVP 5.9
Anakinra 5.8
Zoledronic acid 5.8
Propidium 5.8
Zoledronic acid 5.8
Denosumab 5.7
Etoposide 5.7
Zein 5.7
Bestatin 5.7
Filgrastim 5.4
Filgrastim 5.2
PFT 4.9
EHDP 4.9
Leucovorin 4.8
IL-11 4.7
Adriamycin 4.6
PDL 4.5
Everolimus 4.4
Gleevec 4.3
Simvastatin 4.1
Cetuximab 3.9
ADR 3.8
ADM 3.8
uPA 3.8
Doxycycline 3.7
CDP 3.6
ROS 3.6
Arsenic trioxide 3.5
ETS 3.5
more...
Enzyme
cathepsin F 7.8
phosphatidylinositol-4,5-bisphosphate 3-kinase 7.2
nicotinamide mononucleotide adenylyltransferase 6.8
stromelysin-3 6.8
KLK7 6.3
branched-chain aminotransferase 6.0
inositol 3-kinase 6.0
matrix metalloproteinase 2 5.6
luciferase 5.5
alginate lyase 5.3
GLO 5.2
Protein 2 5.1
matrix metalloproteinase 9 5.0
PARP 5.0
caspase-9 4.9
caspase-6 4.9
caspase-3 4.9
caspase-6 4.9
O-GlcNAc transferase 4.9
MMP 4.6
prostaglandin synthetase 4.6
MEKK1 4.5
caspase-8 4.5
enterokinase 4.4
GSK 4.4
methionine adenosyltransferase 4.4
ornithine aminotransferase 4.3
MEK 4.3
phosphatidylinositol 3-kinase 4.3
polo-like kinase 1 4.2
MCS 4.2
MDP 4.0
ALDH 4.0
cathepsin K 4.0
phosphoinositide 3-kinase 3.9
bromelain 3.8
mitogen-activated protein kinase 3.8
5'-nucleotidase 3.8
PDK1 3.7
MMP-3 3.7
more...
Compound
Sennoside B 12.2
Raddeanin A 11.2
Euxanthone 10.4
Bruceine D 10.2
Picropodophyllin 10.0
Sennoside A 9.3
Tomatidine 9.2
Tomatidine 9.2
Calycosin 9.1
11-aminoundecanoic acid 9.1
MNNG 8.9
Cinobufagin 8.8
Fangchinoline 8.8
N6-Methyladenosine 8.8
Punicalagin 8.4
Berbamine 8.3
Evodiamine 8.3
Evodiamine 8.2
SC-58125 8.2
Alantolactone 8.0
2-Methoxyestradiol 8.0
Lycorine 7.8
Anethole 7.7
Glabridin 7.7
Cucurbitacin B 7.6
Escin 7.6
Escin 7.5
Deguelin 7.5
Celastrol 7.5
Calcein AM 7.4
Noscapine 7.3
Dioscin 7.3
Dioscin 7.3
Oridonin 7.1
Phenethyl isothiocyanate 7.0
Mangostin 6.9
Fisetin 6.8
dADP 6.8
BAPN 6.8
Ifosfamide 6.8
more...