Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1522057 (Colitis)
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Human Gene/Protein
MLCK2 11.2
long myosin light chain kinase 10.3
wingless-type MMTV integration site family, member 5A 10.3
CTRP4 10.2
MUC-3 9.5
calmodulin 3 9.5
DEFA6 9.3
EEN 9.3
IBD 9.0
solute carrier family 9 9.0
M-BAR 8.9
OPLA 8.7
siderophilin 8.3
NOD2 protein 8.3
UST 8.3
chemokine (C-C motif) ligand 3 8.3
CGRP-receptor component protein 8.2
MUC19 8.1
DSS 8.0
Signal transducer and activator of transcription 6 8.0
Vil 7.9
mAKAP 7.8
PEMT 7.8
MBOAT7 7.7
NIMP 7.7
APOH 7.6
CD14 protein 7.4
triggering receptor expressed on myeloid cells 1 7.4
IL-10R1 7.4
TSG-6 7.3
IRGM 7.3
IL10RA 7.2
SLCO2A1 7.2
MAdCAM-1 7.2
P67 7.2
chloride channel protein 7.1
LI-cadherin 7.1
SELL 7.1
G6PC3 7.0
LRG 7.0
pantetheinase 7.0
FMT 6.9
HD5 6.9
ATG16L1 6.8
Fucosyltransferase 6.8
Vanin-1 6.8
SELE 6.8
TM6SF2 6.8
member 9 6.7
CLC-5 6.7
VAP-1 6.7
myeloperoxidase 6.7
GCD 6.7
prostaglandin transporter 6.7
Triggering receptor expressed on myeloid cells 1 6.6
NCF2 6.6
UTF1 6.6
MOR1 6.6
PNR 6.6
Myeloperoxidase 6.5
TATA-box-binding protein 6.5
Hb1 6.5
cholesterol 25-hydroxylase 6.5
T-synthase 6.5
NTR1 6.5
MECL-1 6.5
Cytosolic phospholipase A2 6.5
IL11 6.4
cold-inducible RNA-binding protein 6.4
Vor 6.4
CYP4B1 6.4
FAS ligand 6.4
Janus kinase 1 6.3
sphingosine-1-phosphate receptor 1 6.3
HuC 6.3
IL12A 6.3
CCL25 6.2
NHE-3 6.2
TNF-like weak inducer of apoptosis 6.2
mucin 2 6.2
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Disease
Colitis 13.2
Anorectal cancer 13.2
cecitis 12.3
Nutritional and Metabolic Diseases 12.2
Iliac vein thrombosis 12.2
Vulval Crohn's disease 11.6
Pericholangitis 11.2
colitis 10.6
Fulminant amoebic colitis 10.6
Chronic duodenitis 10.6
Osmotic diarrhea 10.3
Perianal Crohn's disease 10.2
Indeterminate colitis 9.3
Distal colitis 9.3
Chronic colitis 9.3
Diversion colitis 9.1
Inflammatory Bowel Disease 9.1
Antibiotic-associated colitis 9.0
Collagenous sprue 8.9
Hemorrhagic enteritis 8.7
bacterial colitis 8.7
Pyostomatitis vegetans 8.7
jejunitis 8.7
duodenitis 8.7
pig-bel 8.6
Upper gastrointestinal symptoms 8.5
EIM 8.5
small bowel ileus 8.4
Neutropenic enterocolitis 8.2
Eosinophilic colitis 8.2
CMV colitis 8.0
DSS 8.0
dolichocolon 8.0
Histomonosis 8.0
tetrasomy 9p 8.0
Mycobacterium abscessus infection 7.8
Brunner's gland hyperplasia 7.8
inflammatory bowel disease 7.8
DSS 7.8
Witts 7.7
Anterior ischemic optic neuropathy 7.6
Crohn's colitis 7.6
Toxic megacolon 7.5
enteritis 7.4
ileitis 7.3
ulcerative colitis 7.3
Clostridium difficile colitis 7.3
colon neoplasm 7.3
Crohn's disease 7.3
intestinal tuberculosis 7.3
Precancerous lesions 7.2
SLE flare 7.1
Digestive Diseases 7.1
Hypophysitis 7.0
Echinococcus multilocularis infection 7.0
irritable bowel syndrome 6.9
GFD 6.8
rectal polyp 6.6
proctosigmoiditis 6.6
cryptitis 6.5
Salmonella bacteremia 6.5
Crohn's ileitis 6.5
Amebic liver abscess 6.5
infectious enteritis 6.4
Yersinia enterocolitica infection 6.4
central serous retinopathy 6.4
infectious colitis 6.4
Necrotic enteritis 6.3
Collagenous colitis 6.3
Angiodysplasia 6.3
Microscopic colitis 6.3
melanosis coli 6.1
Leukocytoclastic vasculitis 6.1
acute gastritis 6.1
balanoposthitis 6.1
Leukocyte adhesion deficiency 6.1
Pneumatosis intestinalis 6.1
small bowel adenocarcinoma 6.0
Ileum 5.9
Bowel perforation 5.9
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Symptom
localized abdominal pain 8.0
Visceral pain 7.3
generalized abdominal pain 6.6
right lower quadrant pain 5.9
Spastic 5.7
tenesmus 5.3
non-productive cough 5.0
intestinal bleeding 4.5
diarrhea 4.4
ketonuria 4.0
Gastrointestinal symptoms 4.0
leg edema 3.8
colic 3.5
abdominal pain 3.4
blurred vision 3.1
joint stiffness 3.1
urinary frequency 3.0
decreased appetite 3.0
chronic constipation 2.8
sore throat 2.7
chills 2.7
arthralgia 2.7
acute abdomen 2.6
despair 2.5
enuresis 2.5
sneezing 2.3
fever of unknown origin 2.1
heartburn 2.1
acute stress 2.0
dysuria 1.9
constipation 1.8
Wind 1.8
anorexia 1.7
vomiting 1.7
flushing 1.5
erythema 1.5
Ill 1.3
pelvic pain 1.2
nausea and vomiting 0.9
shortness of breath 0.8
cachexia 0.7
lethargy 0.7
hepatomegaly 0.7
nausea 0.6
myalgia 0.5
spasm 0.3
regurgitation 0.1
chest pain 0.1
fatigue 0.1
dyspnea -0.0
low back pain -0.1
pain -0.3
discomfort -0.3
cough -0.4
back pain -0.4
discomfort -0.4
weakness -0.5
sleepiness -0.5
stigma -0.6
analgesia -0.6
acidity -0.7
ataxia -0.8
respiratory distress -1.1
anesthesia -1.6
headache -1.6
collapse -1.7
Drug
Apricot kernel 11.2
Dextran sulfate sodium 8.7
Imodium 8.2
Imodium 7.9
Pentane 7.2
Infliximab 7.2
Infliximab 7.2
Ceftibuten 6.8
Anakinra 6.8
Ipilimumab 6.5
Adalimumab 6.4
Mesalazine 6.3
CED 6.0
Rebamipide 5.9
Bromelain 5.7
Rifaximin 5.5
Giardiasis 5.3
Escitalopram 5.2
Ketotifen 5.0
Prednisolone 4.9
Dasatinib 4.9
Sodium valproate 4.8
Fondaparinux 4.8
Rimonabant 4.8
Rutin 4.8
Colombo 4.8
HPMPC 4.7
Amifostine 4.6
Trimethoprim-sulfamethoxazole 4.6
Doyle 4.5
Aminoguanidine 4.4
Rolipram 4.4
IL-1ra 4.3
CSI 4.3
Ginger 4.3
LMWH 4.1
Salicylate 4.0
Bifidobacterium 4.0
Adenosine deaminase 3.7
Rosiglitazone 3.5
Irinotecan 3.5
Omeprazole 3.2
Prednisone 3.2
IL-11 3.0
BCG vaccine 3.0
Gefitinib 2.9
Horizon 2.9
Arsenic trioxide 2.8
Phenytoin 2.8
Vitamin A 2.6
Acacia 2.5
Award 2.4
Norplant 2.4
IFN-gamma 2.3
MDS 2.0
CDP 2.0
Clonidine 1.9
Alanine 1.7
ALA 1.7
IL-2 1.6
Growth hormone 1.6
Growth hormone 1.6
Heme 1.5
Indomethacin 1.5
Vitamin E 1.5
MRC 1.4
EPA 1.3
ampicillin 1.1
vitamin E 1.1
Ethanol 0.9
citric acid 0.9
G-CSF 0.8
Glutathione 0.8
CTX 0.7
CTX 0.7
ROS -0.1
CTX -0.2
Gel -0.7
Nephron -1.0
ascorbate -1.3
more...
Enzyme
CEAS 9.1
cholesterol 25-hydroxylase 7.7
stem bromelain 6.4
bromelin 6.4
pantetheinase 6.3
neutrophil collagenase 5.6
phosphatidylethanolamine N-methyltransferase 5.3
thiopurine methyltransferase 5.0
AMP deaminase 4.7
peroxidase 4.7
matriptase 4.6
matriptase 4.2
15-hydroxyprostaglandin dehydrogenase 3.9
LPL 3.7
mu-calpain 3.7
rhodanese 3.6
MCS 3.6
p100 3.3
bromelain 3.2
NOS 3.1
matrix metalloproteinase 9 3.0
GRK5 3.0
MIP 2.9
caspase-1 2.9
adenosine deaminase 2.8
11beta-hydroxysteroid dehydrogenase 2.8
adenosine deaminase 2.8
chymase 2.8
neutrophil elastase 2.7
purine nucleoside phosphorylase 2.7
deoxyribonuclease 2.6
deoxyribonuclease 2.6
IKK 2.5
dipeptidyl peptidase IV 2.4
MMP-3 2.4
tryptophan hydroxylase 2.4
TdT 2.3
cathepsin D 2.1
MMP 2.1
lactase 2.1
NO synthase 2.0
superoxide dismutase 2.0
diamine oxidase 1.9
BMT 1.8
myosin light chain kinase 1.8
PARP 1.7
tryptase 1.7
lipoxygenase 1.7
glucose-6-phosphatase 1.6
thyroid peroxidase 1.5
choline acetyltransferase 1.5
CD10 1.5
granzyme B 1.5
aldose reductase 1.5
UDP-glucuronosyltransferase 1.5
caspase-8 1.4
thymidylate synthase 1.3
urease 1.3
urease 1.3
catalase 1.2
heme oxygenase 1.1
lysozyme 1.1
glyceraldehyde-3-phosphate dehydrogenase 1.1
glyceraldehyde-3-phosphate dehydrogenase 1.1
glutathione peroxidase 1.0
glyceraldehyde-3-phosphate dehydrogenase 1.0
glutathione reductase 0.9
transglutaminase 0.9
focal adhesion kinase 0.9
DNA methyltransferase 0.9
NADPH oxidase 0.8
glyceraldehyde-3-phosphate dehydrogenase 0.7
NADPH oxidase 0.7
proteasome 0.7
caspase-3 0.6
NQO1 0.6
AMPK 0.5
acid phosphatase 0.5
glyceraldehyde-3-phosphate dehydrogenase 0.5
aldehyde dehydrogenase 0.5
more...
Compound
Plumieride 10.2
5-amino-2-hydroxybenzoic acid 10.2
Trinitrobenzenesulfonic acid 9.8
ethyl nonanoate 9.2
C10H8O4 9.2
Vicenin-2 8.8
WIN 18,446 8.6
4-Thiouridine 8.5
Aloperine 8.5
1,3-Dinitrobenzene 8.4
TNB 8.3
Kaurenoic acid 8.1
Tributyrin 7.5
Palmatine 7.3
DSS 7.2
Sinapic acid 7.2
Guggulsterone 7.2
Bergapten 7.1
mCPBG 7.0
Geranylgeranylacetone 7.0
Ceftibuten 6.9
TMG 6.8
Azoxymethane 6.7
Osthole 6.7
Sulfasalazine 6.6
Methylsulfonylmethane 6.6
Mesalamine 6.6
Catalpol 6.1
CD 3 6.1
Caryophyllene 5.9
6-Gingerol 5.9
Tylosin 5.8
Celastrol 5.8
Granisetron 5.6
Hesperetin 5.6
Sanguinarine 5.6
6-Mercaptopurine 5.5
Genipin 5.5
Azathioprine 5.5
Diosgenin 5.4
Inactin 5.3
Ropivacaine 5.2
Caffeic acid phenethyl ester 5.2
Mesna 5.2
Montelukast 5.0
Thiobarbituric acid 5.0
Prednisolone 5.0
Betulinic acid 4.9
Loperamide 4.9
Flavonoid 4.8
TIB 4.8
celastrol 4.8
Meloxicam 4.8
Tannin 4.8
Methimazole 4.7
CoM 4.7
Amifostine 4.6
Neostigmine 4.6
TBC 4.5
Dextran 4.5
Puerarin 4.5
1,2-dimethylhydrazine 4.3
Rutin 4.3
TNF 4.3
Cannabidiol 4.3
BDS 4.2
NKT 4.2
DETA 4.1
RU-486 4.1
Chlorogenic acid 4.1
Inosine 4.1
acetic acid 4.0
DHBA 4.0
nonyl 4.0
sulfate 4.0
T13 4.0
Carrageenan 4.0
Deoxynivalenol 3.9
decyl 3.9
decyl 3.9
more...