Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1522057 (
Colitis
)
3,500
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The sodium-hydrogen exchanger isoform,
NHE-3
is essential for the absorption of sodium and water from intestine. Whether this protein plays any role in inflammatory bowel disease is less understood. To address this issue,
NHE-3
mRNA and protein levels were estimated in the terminal ileum and colon of the rats having colitis induced with trinitrobenzenesulphonic acid (TNBS). The effect of garlic (Allium sativum) was also evaluated on the expression of
NHE-3
. The animals were treated with garlic extract intraperitoneally starting 2 h before the TNBS administration until day 4 post-TNBS administration and were sacrificed on day 5. In control animals, the levels of
NHE-3
in colon was higher than the ileum. As a result of colitis, the levels of
NHE-3
protein and mRNA increased both in the colon and terminal ileum. Garlic treatment of the colitic animals resulted in a selective suppression of
NHE-3
in the terminal ileum.
Colitis
caused an induction of the myeloperoxidase activity, the marker of inflammation in the colon but not in the ileum. These findings suggest that induction of
NHE-3
is not primarily due to inflammation. Selective suppression of this protein in ileum by garlic may cause loss of sodium chloride and water during colitis.
...
PMID:Altered expression of the Na+/H+ exchanger isoform-3 in experimental colitis: effect of garlic. 1056 86
