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Query: UMLS:C1522057 (Colitis)
 3,500 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A survey of the histology of 2,024 small intestinal suction and forceps biopsies in 400 dogs, consisting of 17 clinically healthy control dogs and 383 dogs with chronic diarrhea is presented. Three and a half percent of the suction biopsies and 22.6 percent of the forceps biopsies were unsuitable for examination, making a diagnosis impossible in 9 dogs, and in 0.4 percent antral mucosa was present. Biopsies could be obtained from the proximal one third of the small intestine. The normal histology, including mean villous length, its standard deviation and its range is described in the 17 control dogs. A classification of enteritis in dogs is given. Villous atrophy without enteritis was found in 55 dogs with chronic diarrhea; 51 dogs had moderate and four severe villous atrophy. Villous atrophy combined with enteritis was found in 93 dogs, 57 of which had lymphocytic-plasmacytic enteritis, 14 had eosinophilic enteritis, six catarrhal, four ulcerative, 11 a combination of lymphocytic-plasmacytic and eosinophilic enteritis and one dog had a combination of lymphocytic-plasmacytic and catarrhal enteritis. Enteritis without villous atrophy was found in 50 dogs: 39 had lymphocytic-plasmacytic enteritis, four eosinophilic, two catarrhal, one purulent (microabscesses), three a combination of lymphocytic-plasmacytic and eosinophilic enteritis and one dog had focal necrosis. Twelve dogs showed a lymphosarcoma and in eight other dogs a differential diagnosis of lymphosarcoma and/or enteritis was made. One carcinoma was found. Other findings were hemorrhages, oedema, erosions, muscular hypertrophy in the villi, an increased or decreased number of intraepithelial lymphocytes, an increased or decreased number of goblet cells, lymphangiectasia, crypt cysts, crypt abscesses and gastric metaplasia. Some breeds, such as the German Shepherd dog, Bouvier des Flandres, Spaniel, Collie, Great Dane and Retriever appear to be more susceptible than other breeds for villous atrophy and enteritis. A slight prevalence of the German Shepherd dog, Doberman Pinscher and Rottweiler was also observed for eosinophilic enteritis. Mild villous atrophy is mostly found in dogs aged 0-4 years, whereas severe villous atrophy is found in dogs older than 4 years. Further breed, age or sex predisposition could not be found. The method appears especially useful for diffuse mucosal lesions of the proximal small intestine.
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PMID:The histological appearance of peroral small intestinal biopsies in clinically healthy dogs and dogs with chronic diarrhea. 212 Aug 63

The results of follow-up studies in 77 dogs with clinical signs of large bowel disease are presented. In 32 dogs colonic and/or rectal biopsy follow-up studies were done, combined with necropsy in seven dogs. In 45 dogs a follow-up necropsy only was done. The time between the first and the last series of biopsies varied from three to 729 days and between the first series of biopsies and necropsy from one to 980 days. Colitis found in 45 dogs in the initial biopsies was still present in 29 cases in the follow-up biopsy studies and/or at necropsy. Eleven cases showed hystiocytic ulcerative colitis. In general, adenoma, carcinoma and lymphosarcoma were confirmed in the follow-up examination, except for one adenoma, which appeared to be a carcinoma at necropsy. In cases in which the differential diagnosis was adenoma or carcinoma, the necropsy diagnosis was always carcinoma and in cases of a differential diagnosis of lymphosarcoma and/or colitis, lymphosarcoma was always diagnosed at necropsy. Several dogs without colonic changes in the initial biopsies had other gastric or small intestinal lesions at necropsy such as gastritis and enteritis of the small intestine, or tumors, in these areas.
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PMID:Follow-up studies by large intestinal biopsies and necropsy in dogs with clinical signs of large bowel disease. 259 Aug 75

Colonic and rectal forceps and excision biopsies of 355 dogs with clinical signs of large bowel disease were investigated. Five percent of the forceps biopsies were unsuitable for examination; all excision biopsies were of good quality. Forceps biopsies were obtained from one to eight sites, up to 60 cm cranial from the anus, while excision biopsies, mostly from tumors, were from the rectoanal region. Slight to severe colitis and/or proctitis was found in 192 dogs (54%). A single type of colitis was seen in 160 dogs; in 53 cases the lesions were local, in 107 cases multiple. A combination of different types of colitis was found in 32 dogs. Atrophic colitis, diffuse colitis and canine histiocytic ulcerative colitis were the most prominent findings, followed by ulcerative, superficial and eosinophilic colitis. Follicular, hypertrophic and aspecific granulomatous colitis were found in only a few cases. Tumors were diagnosed in 57 dogs (16%). Of these tumors 50 were of epithelial and seven were of mesenchymal origin. A high percentage (61%) of the epithelial tumors consisted of adenomas of the rectoanal region. In ten other dogs (3%) a differential diagnosis of lymphosarcoma or colitis had to be made. Colitis and colorectal tumors were more prevalent in Boxers, German Shepherds, Poodles, Great Danes and Spaniels. In the Boxers simple chronic colitis, as well as canine histiocytic ulcerative colitis were more frequently found, the latter especially in females. Other biopsy findings were edema, crypt cysts, hemorrhages, an increased number of intraepithelial lymphocytes and an increased or decreased number of goblet cells.
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PMID:The histological appearance of large intestinal biopsies in dogs with clinical signs of large bowel disease. 334 3