Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1519670 (tumor angiogenesis)
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Human Gene/Protein
TEM5-like protein 12.4
discoidin domain receptor family, member 1 11.4
FGF intracellular binding protein 11.4
SEZ6L2 protein 11.4
prion-like protein doppel 11.4
KIAA1212 11.4
VIK-1 11.4
eukaryotic translation initiation factor 4E nuclear import factor 1 10.8
ZNF655 10.8
LRFN1 10.8
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 10.8
TNFAIP2 protein 10.8
semaphorin 6D 10.6
FPTA 10.4
BLP2 10.4
type IV collagen alpha3 chain 10.0
Transgelin 2 10.0
TEM5 10.0
CDS 2 10.0
Galanin receptor 2 10.0
Myocyte enhancer factor 2D 10.0
CHI3L1 protein 10.0
VASH2 10.0
EGFL6 9.9
TrpC5 9.8
NDRG3 protein 9.8
hCLOCK 9.8
FGF-BP3 9.8
G protein-coupled receptor 124 9.8
SEZ6L2 9.6
RAB11B 9.6
Angiopoietin 2 9.5
endogenous angiogenesis inhibitor 9.5
SI-CLP 9.5
Interleukin-24 9.5
geranylgeranyl transferase II 9.4
HSPA12B 9.4
TSR2 9.4
CYP4Z2P 9.4
hematopoietic progenitor cell antigen CD34 9.4
Vasohibin-1 9.3
RASAL2 9.3
ANG2 9.2
YKL-39 9.2
TEA domain family member 4 9.2
ARL7 9.2
TEM8 9.2
EGF-like domain-containing protein 3 9.2
DARC protein 9.2
ELTD1 9.0
SEMA3G 9.0
protein synthesis factor 9.0
PSG9 9.0
mutant VHL 9.0
Kallikrein-related peptidase 4 9.0
TMEM176B 9.0
ANGPT4 9.0
ING4 8.9
IL20RB 8.9
Chemokine receptor 4 8.9
CYP4Z1 8.9
GDF-1 8.9
D-glucuronyl C5-epimerase 8.9
S100 calcium-binding protein A16 8.9
headpin 8.9
NEK10 8.9
EIF3C 8.9
FIH1 8.9
Angiopoietin-2 8.8
Endostatin 8.8
APLN 8.8
IFP1 8.8
hurpin 8.8
focal adhesion kinase 1 8.8
FJX1 8.8
arresten 8.7
Fos-related antigen 1 8.7
IBTK 8.7
SNRK 8.7
MAP3K6 8.7
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Disease
tumor angiogenesis 12.4
Staphylococcal osteomyelitis 10.8
tumor vasculature 9.3
skin cancer, basal cell 9.2
cancer angiogenesis 9.1
Lewis Lung Carcinoma 8.3
VIN II 7.9
small cell carcinoma of the cervix 7.6
VIN I 7.6
TSHoma 7.5
tumor growth 7.2
oligodendroglial tumor 7.2
salivary gland adenoid cystic carcinoma 7.1
KNS 7.1
BRCAX 7.0
AD4 6.9
verruga peruana 6.9
PLAT 6.9
VIN III 6.9
angiectasis 6.9
anthracosilicosis 6.8
Ehrlich Ascites Tumor 6.8
tumor progression 6.5
AML progression 6.5
androgen independent prostate cancer 6.5
ACTH-secreting pituitary adenoma 6.4
mixed gliomas 6.4
Hepatocarcinogenesis 6.3
ovarian cancer stage 6.3
Reversible posterior leukoencephalopathy syndrome 6.3
Oral Cancer 6.2
HHT2 6.2
SAMS 6.2
FIH 6.2
solid tumor 6.1
gliosarcoma 6.0
Bacillary angiomatosis 6.0
Metastatic colorectal cancer 5.9
high-risk cancer 5.9
adult brain tumor 5.8
Hippel 5.8
Meningeal carcinomatosis 5.7
in situ breast cancer 5.7
islet cell carcinoma 5.6
SFD 5.6
Glioblastoma 5.6
Malignant glioma 5.6
malignant ascites 5.6
hand-foot syndrome 5.6
Chondrosarcoma 5.6
Chondrosarcoma 5.6
chloroma 5.5
dermatofibrosarcoma 5.5
lymphatic vessels 5.5
pediatric solid tumor 5.5
eye cancer 5.4
large cell carcinomas 5.4
tumor initiation 5.4
HGF 5.4
hypopharyngeal squamous cell carcinoma 5.4
glioblastoma 5.4
sarcoma 180 5.4
malignant pleural effusion 5.4
IRD 5.4
lung metastases 5.3
renal clear cell carcinoma 5.3
CADASIL 5.3
uterine carcinosarcoma 5.3
metastatic cervical cancer 5.2
Diabetic complications 5.2
fibrosarcoma 5.1
recurrent ovarian cancer 5.1
metastatic renal cell carcinoma 5.1
peritoneal cancer 5.1
tumor 5.0
tubulovillous adenoma 5.0
Tag 5.0
carcinoma of the tongue 5.0
stage I NSCLC 5.0
FGG 5.0
more...
Symptom
Flu-like symptoms 6.6
Scratch 3.7
rundown 3.4
rigors 2.7
dry skin 2.4
productive cough 2.2
cachexia 2.2
decreased appetite 2.2
night sweats 2.1
asthenia 2.0
skin damage 1.8
starvation 1.6
sneezing 1.5
hypercapnia 1.4
hemoptysis 1.4
skin irritation 1.3
rhinorrhea 1.2
hyperoxia 1.0
cancer pain 0.8
nausea 0.7
pelvic pain 0.4
apathy 0.4
collapse 0.4
chills 0.3
hepatosplenomegaly 0.3
diarrhea -0.1
flushing -0.3
vomiting -0.6
fatigue -0.7
nausea and vomiting -0.9
splenomegaly -0.9
constipation -1.0
thinning -1.1
erythema -1.3
overweight -1.3
functional recovery -1.4
exhaustion -1.4
anorexia -1.4
analgesia -1.4
acidity -1.5
ataxia -1.6
pain -1.8
headache -1.8
respiratory distress -1.9
seizures -1.9
anesthesia -2.4
dyspnea -2.4
weakness -2.8
Drug
Tecogalan sodium 12.4
Arresten 10.9
Lexatumumab 9.8
Masoprocol 9.8
Semaxanib 9.7
Masoprocol 9.6
Torisel 9.0
Cilengitide 8.2
Prinomastat 8.2
Oncophage 8.2
Bevacizumab 8.0
Plaunotol 8.0
Nexavar 7.6
Alvimopan 7.2
Marimastat 7.2
2-Methoxyestradiol 7.0
Aggrastat 7.0
Leukine 6.9
Axitinib 6.9
Vatalanib 6.9
Vandetanib 6.9
Sorafenib 6.7
Barium sulfate 6.6
Gliadel 6.3
Tarceva 6.2
Sunitinib malate 6.2
Gabexate mesilate 6.1
Sonazoid 6.0
Optison 5.8
Onconase 5.6
Intal 5.6
Compound 18 5.5
Romidepsin 5.5
Methylcellulose 5.5
Protamine sulfate 5.4
Celebrex 5.4
CTT 5.3
Omniscan 5.3
Eptifibatide 5.2
Bestatin 5.2
Paraffin 5.0
Optison 4.9
Erlotinib 4.8
Carbenoxolone 4.8
Cetuximab 4.8
Pemetrexed 4.7
Irinotecan 4.7
Tranilast 4.7
Taxotere 4.7
CoCl2 4.7
CoCl2 4.7
uPA 4.6
Verteporfin 4.6
Gefitinib 4.5
KGF 4.4
Iopamidol 4.4
Clodronate 4.4
Arsenic trioxide 4.4
Nebivolol 4.3
Sucralfate 4.2
Gleevec 4.2
Nimesulide 4.1
RFP 4.1
Abciximab 4.1
Myricetin 4.1
Urokinase 4.1
TAK 4.0
Artesunate 3.9
Docetaxel 3.9
Vorinostat 3.9
Gelfoam 3.8
DMSA 3.8
Bortezomib 3.8
BH4 3.8
Pravastatin 3.7
Imatinib 3.7
Tocilizumab 3.6
Vinorelbine 3.6
Activin 3.6
Diclofenac sodium 3.6
more...
Enzyme
8-lipoxygenase 7.6
tubulin carboxypeptidase 7.0
thymidine phosphorylase 6.9
adamalysin 6.1
cancer procoagulant 5.8
TSP-1 5.8
coagulation factor VIIa 5.7
3-mercaptopyruvate sulfurtransferase 5.5
legumain 5.3
cathepsin X 5.2
arachidonate 5-lipoxygenase 5.1
protein farnesyltransferase 5.1
matrix metalloproteinase 9 5.1
N-acetylglucosaminyltransferase V 5.0
12-lipoxygenase 4.9
tryptase 4.9
MMP 4.9
CD13 4.9
TSR 4.9
prolyl hydroxylase 4.9
nicotinamide phosphoribosyltransferase 4.8
ERK 4.7
HCS 4.7
uracil phosphoribosyltransferase 4.7
seryl-tRNA synthetase 4.7
aminopeptidase B 4.6
urokinase-type plasminogen activator 4.6
SCP 4.5
inositol 3-kinase 4.5
phosphoinositide 3-kinase 4.5
sulfhydryl oxidase 4.4
matrix metalloproteinase 2 4.2
phosphatidylinositol 3-kinase 4.2
dimethylarginine dimethylaminohydrolase 4.1
uridine phosphorylase 4.1
15-hydroxyprostaglandin dehydrogenase 4.1
MEK 4.0
FPS 3.9
cathepsin B 3.9
matriptase 3.8
sphingosine kinase 3.8
CEP 3.8
MMP-3 3.8
mitogen-activated protein kinase 3.8
carboxypeptidase E 3.7
focal adhesion kinase 3.7
lysyl oxidase 3.7
aminopeptidase A 3.6
prostate-specific membrane antigen 3.6
CGT 3.6
PDK1 3.6
BMA 3.5
STK11 3.5
interstitial collagenase 3.5
indoleamine 2,3-dioxygenase 3.5
lysyl endopeptidase 3.4
prolidase 3.4
plasmin 3.4
matriptase 3.4
sialyltransferase 3.4
TGT 3.4
sialyltransferase 3.4
sialyltransferase 3.4
farnesyltransferase 3.3
aromatic L-amino acid decarboxylase 3.3
ADPase 3.3
proprotein convertase 3.3
CEP 3.3
thromboxane synthase 3.2
15-lipoxygenase 3.2
MTD 3.1
luciferase 3.1
carboxypeptidase B 3.1
prostaglandin synthetase 3.1
PAM 3.1
AMPK 3.1
endothelin-converting enzyme 3.0
DCF 3.0
GTP cyclohydrolase I 3.0
chymase 3.0
more...
Compound
C25H30N2O5 12.4
dodecyl carbamate 12.4
Convallamaroside 12.4
Dipalmitoylphosphatidic acid 10.8
3-undecanone 10.8
N-methyl-1-naphthamide 10.8
4-undecanone 10.8
Marmesin 10.4
Depostat 9.8
Vernolide 9.8
C14H12N4OS 9.8
alpha-Chaconine 9.6
Marmesin 9.6
1,2,4,5-benzenetetramine 9.4
2,4-dimethyl-1H-pyrrole 8.9
Benzarone 8.9
quinuclidin-3-ol 8.9
C11H16O3 8.8
C5H8N2 8.6
Lariciresinol 8.4
Eupafolin 8.1
Xanthatin 8.1
D-ribose-1-phosphate 8.0
Borrelidin 8.0
Borrelidin 7.9
Xanthatin 7.7
Pristimerin 7.6
Pristimerin 7.6
Pristimerin 7.6
Pristimerin 7.6
2-(2-methoxyethoxy)ethanol 7.6
Cucurbitacin I 7.6
Ergosterol peroxide 7.6
Scutellarein 7.6
1-piperidinecarboxamide 7.6
2,6-piperidinedione 7.6
Anacardic acid 7.5
2-naphthalenesulfonic acid 7.5
2,6-piperidinedione 7.5
Morusin 7.5
MTIC 7.3
Deguelin 7.1
2-Methoxyestradiol 7.0
Genistin 7.0
6-hydroxynicotinic acid 6.9
Wogonin 6.9
6-hydroxynicotinic acid 6.9
Gambogic acid 6.9
Theaflavin 6.9
1-octacosanol 6.8
7H-pyrrolo[2,3-d]pyrimidine 6.8
Brucine 6.7
PKF 6.7
Tetrahydrocurcumin 6.7
Oridonin 6.7
Tricin 6.7
APN 6.7
FUR 6.6
Pimonidazole 6.6
Pimonidazole 6.6
Diosmetin 6.4
Gadodiamide 6.4
Acacetin 6.4
Sepiapterin 6.3
Benzbromarone 6.2
Costunolide 6.2
Flubendazole 6.2
Cucurbitacin B 6.2
Zingerone 6.1
Xanthohumol 6.1
Butein 6.0
Temsirolimus 6.0
Celastrol 6.0
CUE 5.9
Nobiletin 5.9
PGE3 5.8
Dioscin 5.8
Dioscin 5.8
Emetine 5.8
Roxithromycin 5.8
more...