Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1519670 (tumor angiogenesis)
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Human Gene/Protein
TEM5-like protein 12.4
prion-like protein doppel 11.4
KIAA1212 11.4
discoidin domain receptor family, member 1 11.4
SEZ6L2 protein 11.4
FGF intracellular binding protein 11.4
VIK-1 11.4
eukaryotic translation initiation factor 4E nuclear import factor 1 10.8
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 10.8
TNFAIP2 protein 10.8
ZNF655 10.8
LRFN1 10.8
semaphorin 6D 10.6
BLP2 10.4
FPTA 10.4
Galanin receptor 2 10.0
type IV collagen alpha3 chain 10.0
Transgelin 2 10.0
CHI3L1 protein 10.0
TEM5 10.0
Myocyte enhancer factor 2D 10.0
CDS 2 10.0
VASH2 10.0
EGFL6 9.9
TrpC5 9.8
hCLOCK 9.8
NDRG3 protein 9.8
G protein-coupled receptor 124 9.8
FGF-BP3 9.8
SEZ6L2 9.6
RAB11B 9.6
Angiopoietin 2 9.5
endogenous angiogenesis inhibitor 9.5
Interleukin-24 9.5
SI-CLP 9.5
CYP4Z2P 9.4
HSPA12B 9.4
TSR2 9.4
hematopoietic progenitor cell antigen CD34 9.4
geranylgeranyl transferase II 9.4
Vasohibin-1 9.3
RASAL2 9.3
ANG2 9.2
TEM8 9.2
EGF-like domain-containing protein 3 9.2
TEA domain family member 4 9.2
ARL7 9.2
DARC protein 9.2
YKL-39 9.2
SEMA3G 9.0
ELTD1 9.0
Kallikrein-related peptidase 4 9.0
PSG9 9.0
ANGPT4 9.0
protein synthesis factor 9.0
TMEM176B 9.0
mutant VHL 9.0
EIF3C 8.9
headpin 8.9
GDF-1 8.9
IL20RB 8.9
ING4 8.9
NEK10 8.9
Chemokine receptor 4 8.9
CYP4Z1 8.9
S100 calcium-binding protein A16 8.9
FIH1 8.9
D-glucuronyl C5-epimerase 8.9
Angiopoietin-2 8.8
Endostatin 8.8
FJX1 8.8
hurpin 8.8
IFP1 8.8
APLN 8.8
focal adhesion kinase 1 8.8
arresten 8.7
Fos-related antigen 1 8.7
FBXO22 8.7
MAGP2 8.7
SNRK 8.7
MAP3K6 8.7
ATP1B3 8.7
TIE2 8.7
cytokine-independent survival kinase 8.7
Hoxb-13 8.7
IBTK 8.7
semaphorin 3F 8.6
NRP2 8.6
GPR124 8.6
metargidin 8.6
BNF1 8.6
RIN2 8.6
WSB-1 8.6
Multimerin-2 8.6
PSMC3IP 8.6
TEX15 8.6
lysosomal protein transmembrane 4 beta 8.6
RCAN3 8.6
MVD 8.5
Vascular endothelial growth factor 8.5
soluble VEGFR2 8.5
ENOX1 8.5
angiocidin 8.5
plexin D1 8.5
AMOTL2 8.5
CT50 8.5
TSGA10 8.5
vascular endothelial growth factor receptor 2 8.4
Netrin-4 8.4
VEGFR2 8.4
RECK protein 8.4
LGMN 8.4
TRIM6 8.4
ANKHD1 8.4
Prokineticin-2 8.4
Aquaporin 1 8.3
CLEC14A 8.3
Tie-2 8.3
flt 8.3
DEF6 8.3
NgR2 8.3
ZNF24 8.3
PLXND1 8.3
ADM2 8.3
lysyl hydroxylase 1 8.3
CITED4 8.3
ANGPT2 8.3
neuropilin 2 8.2
neuropilin 8.2
Heparanase 8.2
PIGF 8.2
EVX1 8.2
CXCL4L1 8.2
LLC1 8.2
KLHL20 8.2
RND1 8.2
DUTT1 8.2
metastasis associated protein 8.2
PRKD2 8.2
semaphorin 3B 8.2
BRF2 8.2
opn 8.2
Angiogenin 8.1
CUL-2 8.1
PRL3 8.1
EYA3 8.1
UQCRB 8.1
p55PIK 8.1
PROK1 8.1
TEF3 8.1
vascular endothelial growth factor A 8.1
KDR 8.1
ANG1 8.1
IL-1F8 8.0
HYAL3 8.0
QPC 8.0
VEGF-B 8.0
NDRG3 8.0
ETV2 8.0
Tissue inhibitor of metalloproteinase 1 8.0
more...
Disease
tumor angiogenesis 12.4
Staphylococcal osteomyelitis 10.8
tumor vasculature 9.3
skin cancer, basal cell 9.2
cancer angiogenesis 9.1
Lewis Lung Carcinoma 8.3
VIN II 7.9
small cell carcinoma of the cervix 7.6
VIN I 7.6
TSHoma 7.5
tumor growth 7.2
oligodendroglial tumor 7.2
KNS 7.1
salivary gland adenoid cystic carcinoma 7.1
BRCAX 7.0
PLAT 6.9
AD4 6.9
verruga peruana 6.9
VIN III 6.9
angiectasis 6.9
anthracosilicosis 6.8
Ehrlich Ascites Tumor 6.8
tumor progression 6.5
AML progression 6.5
androgen independent prostate cancer 6.5
ACTH-secreting pituitary adenoma 6.4
mixed gliomas 6.4
Hepatocarcinogenesis 6.3
ovarian cancer stage 6.3
Reversible posterior leukoencephalopathy syndrome 6.3
Oral Cancer 6.2
HHT2 6.2
FIH 6.2
SAMS 6.2
solid tumor 6.1
gliosarcoma 6.0
Bacillary angiomatosis 6.0
Metastatic colorectal cancer 5.9
high-risk cancer 5.9
adult brain tumor 5.8
Hippel 5.8
Meningeal carcinomatosis 5.7
in situ breast cancer 5.7
islet cell carcinoma 5.6
SFD 5.6
Glioblastoma 5.6
Malignant glioma 5.6
malignant ascites 5.6
hand-foot syndrome 5.6
Chondrosarcoma 5.6
Chondrosarcoma 5.6
chloroma 5.5
dermatofibrosarcoma 5.5
lymphatic vessels 5.5
pediatric solid tumor 5.5
eye cancer 5.4
large cell carcinomas 5.4
tumor initiation 5.4
HGF 5.4
hypopharyngeal squamous cell carcinoma 5.4
glioblastoma 5.4
sarcoma 180 5.4
malignant pleural effusion 5.4
IRD 5.4
lung metastases 5.3
renal clear cell carcinoma 5.3
CADASIL 5.3
uterine carcinosarcoma 5.3
metastatic cervical cancer 5.2
Diabetic complications 5.2
fibrosarcoma 5.1
recurrent ovarian cancer 5.1
metastatic renal cell carcinoma 5.1
peritoneal cancer 5.1
tumor 5.0
tubulovillous adenoma 5.0
Tag 5.0
carcinoma of the tongue 5.0
stage I NSCLC 5.0
FGG 5.0
metastatic osteosarcoma 4.9
AA1 4.9
Alveolar soft part sarcoma 4.9
renal cancer 4.9
tumorigenesis 4.9
hemangiosarcoma 4.9
glioma 4.9
mimicry 4.9
renal cell carcinoma 4.9
Cavernous hemangioma 4.9
EMT 4.9
OCM 4.9
Hepatocellular carcinoma 4.9
Liver regeneration 4.8
mammary tumor 4.8
hemangioblastoma 4.8
primary tumor 4.8
Dedifferentiation 4.8
aggressiveness 4.8
lung carcinoma 4.8
non-small cell lung cancer 4.8
anaplastic thyroid cancer 4.7
squamous cell lung cancer 4.7
brain tumor 4.7
pancreatic cancer 4.7
glioblastoma multiforme 4.7
epithelial ovarian cancer 4.6
cancer recurrence 4.6
Malignant peripheral nerve sheath tumor 4.6
CGD 4.6
SCP 4.5
ATN 4.5
melanoma 4.5
benign nevi 4.5
Kidney Cancer 4.5
malignant meningioma 4.5
afibrinogenemia 4.5
HEP 4.5
SCID 4.5
colon cancer 4.5
colorectal cancer 4.4
Carcinosarcoma 4.4
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 4.4
squamous cell carcinoma of the skin 4.4
HCC 4.4
metastatic pancreatic cancer 4.4
infiltrating ductal carcinoma 4.3
FHA 4.3
leukemoid reaction 4.3
ovarian cancer 4.3
MIN 4.3
MIN 4.3
CNS tumors 4.3
TEC 4.3
laryngeal squamous cell carcinoma 4.3
neuroendocrine tumor 4.3
chemical carcinogenesis 4.2
metastatic neuroblastoma 4.2
metastatic bladder cancer 4.2
lymphomatoid granulomatosis 4.2
CNS cancer 4.2
hepatocellular carcinoma 4.2
metastases 4.2
Lip 4.2
intracranial tumors 4.2
LIS1 4.2
Nasopharyngeal carcinoma 4.1
carcinomatosis 4.1
MLS 4.1
Dukes 4.1
Giant cell tumor of bone 4.1
HRA 4.1
chloroma 4.1
Ullrich 4.1
Colorectal Cancer 4.1
metastatic breast cancer 4.1
Desmoplastic small round cell tumor 4.1
hypertensive nephropathy 4.1
squamous cell carcinoma 4.1
carcinoma of the cervix 4.1
more...
Symptom
Flu-like symptoms 6.6
Scratch 3.7
rundown 3.4
rigors 2.7
dry skin 2.4
productive cough 2.2
cachexia 2.2
decreased appetite 2.2
night sweats 2.1
asthenia 2.0
skin damage 1.8
starvation 1.6
sneezing 1.5
hypercapnia 1.4
hemoptysis 1.4
skin irritation 1.3
rhinorrhea 1.2
hyperoxia 1.0
cancer pain 0.8
nausea 0.7
pelvic pain 0.4
apathy 0.4
collapse 0.4
chills 0.3
hepatosplenomegaly 0.3
diarrhea -0.1
flushing -0.3
vomiting -0.6
fatigue -0.7
nausea and vomiting -0.9
splenomegaly -0.9
constipation -1.0
thinning -1.1
erythema -1.3
overweight -1.3
functional recovery -1.4
exhaustion -1.4
anorexia -1.4
analgesia -1.4
acidity -1.5
ataxia -1.6
pain -1.8
headache -1.8
respiratory distress -1.9
seizures -1.9
anesthesia -2.4
dyspnea -2.4
weakness -2.8
Drug
Tecogalan sodium 12.4
Arresten 10.9
Masoprocol 9.8
Lexatumumab 9.8
Semaxanib 9.7
Masoprocol 9.6
Torisel 9.0
Oncophage 8.2
Cilengitide 8.2
Prinomastat 8.2
Bevacizumab 8.0
Plaunotol 8.0
Nexavar 7.6
Alvimopan 7.2
Marimastat 7.2
2-Methoxyestradiol 7.0
Aggrastat 7.0
Axitinib 6.9
Leukine 6.9
Vatalanib 6.9
Vandetanib 6.9
Sorafenib 6.7
Barium sulfate 6.6
Gliadel 6.3
Sunitinib malate 6.2
Tarceva 6.2
Gabexate mesilate 6.1
Sonazoid 6.0
Optison 5.8
Onconase 5.6
Intal 5.6
Compound 18 5.5
Romidepsin 5.5
Methylcellulose 5.5
Protamine sulfate 5.4
Celebrex 5.4
CTT 5.3
Omniscan 5.3
Eptifibatide 5.2
Bestatin 5.2
Paraffin 5.0
Optison 4.9
Erlotinib 4.8
Carbenoxolone 4.8
Cetuximab 4.8
Pemetrexed 4.7
Irinotecan 4.7
Tranilast 4.7
Taxotere 4.7
CoCl2 4.7
CoCl2 4.7
uPA 4.6
Verteporfin 4.6
Gefitinib 4.5
KGF 4.4
Iopamidol 4.4
Clodronate 4.4
Arsenic trioxide 4.4
Nebivolol 4.3
Sucralfate 4.2
Gleevec 4.2
Nimesulide 4.1
RFP 4.1
Abciximab 4.1
Myricetin 4.1
Urokinase 4.1
TAK 4.0
Artesunate 3.9
Docetaxel 3.9
Vorinostat 3.9
Gelfoam 3.8
DMSA 3.8
Bortezomib 3.8
BH4 3.8
Pravastatin 3.7
Imatinib 3.7
Tocilizumab 3.6
Vinorelbine 3.6
Activin 3.6
Diclofenac sodium 3.6
Gelatin 3.6
beta-Galactosidase 3.6
Lovastatin 3.6
Epigallocatechin 3.6
Ezetimibe 3.5
Hyaluronidase 3.5
Oxaliplatin 3.5
Emodin 3.5
CAM 3.4
NVP 3.4
Hyaluronidase 3.4
Zoledronic acid 3.4
Leucovorin 3.4
Glutamic acid 3.4
LMWH 3.3
Doxycycline 3.3
TES 3.2
Emodin 3.2
Azithromycin 3.1
Serum albumin 3.1
Cremophor EL 3.1
Glide 3.1
Taxol 3.0
Lenalidomide 3.0
Meth 3.0
Everolimus 2.9
Prednisolone 2.8
Herceptin 2.8
Fragment 2.8
GEO 2.8
Bayer 2.7
AGG 2.7
Zoledronic acid 2.7
TAT 2.7
Ginseng 2.7
Simvastatin 2.7
Retinoic acid 2.6
ETS 2.6
DEX 2.5
CPT-11 2.5
Monensin 2.5
DDAVP 2.5
DDAVP 2.4
Itraconazole 2.4
IFN-beta 2.4
G-CSF 2.3
CTC 2.3
IL-11 2.2
G418 2.2
Estrogens 2.2
Etoposide 2.2
Captopril 2.2
Adriamycin 2.2
AMC 2.2
Fentanyl 2.0
ROS 2.0
CTC 2.0
CCL 2.0
p75 2.0
IFN-gamma 2.0
NBT 2.0
ICI 2.0
BLM 2.0
IL-1ra 1.9
Glycyrrhiza 1.9
DM1 1.7
Ranitidine 1.7
Cimetidine 1.7
TAC 1.7
Cimetidine 1.7
Norplant 1.6
TTC 1.5
CSF 1.4
MAP 1.4
CTX 1.4
Indomethacin 1.3
EPI 1.3
DHT 1.3
DHT 1.2
Silica 1.1
more...
Enzyme
8-lipoxygenase 7.6
tubulin carboxypeptidase 7.0
thymidine phosphorylase 6.9
adamalysin 6.1
cancer procoagulant 5.8
TSP-1 5.8
coagulation factor VIIa 5.7
3-mercaptopyruvate sulfurtransferase 5.5
legumain 5.3
cathepsin X 5.2
arachidonate 5-lipoxygenase 5.1
protein farnesyltransferase 5.1
matrix metalloproteinase 9 5.1
N-acetylglucosaminyltransferase V 5.0
12-lipoxygenase 4.9
tryptase 4.9
MMP 4.9
CD13 4.9
TSR 4.9
prolyl hydroxylase 4.9
nicotinamide phosphoribosyltransferase 4.8
ERK 4.7
HCS 4.7
uracil phosphoribosyltransferase 4.7
seryl-tRNA synthetase 4.7
aminopeptidase B 4.6
urokinase-type plasminogen activator 4.6
SCP 4.5
inositol 3-kinase 4.5
phosphoinositide 3-kinase 4.5
sulfhydryl oxidase 4.4
matrix metalloproteinase 2 4.2
phosphatidylinositol 3-kinase 4.2
uridine phosphorylase 4.1
dimethylarginine dimethylaminohydrolase 4.1
15-hydroxyprostaglandin dehydrogenase 4.1
MEK 4.0
FPS 3.9
cathepsin B 3.9
sphingosine kinase 3.8
matriptase 3.8
CEP 3.8
MMP-3 3.8
mitogen-activated protein kinase 3.8
carboxypeptidase E 3.7
focal adhesion kinase 3.7
lysyl oxidase 3.7
aminopeptidase A 3.6
prostate-specific membrane antigen 3.6
CGT 3.6
PDK1 3.6
BMA 3.5
STK11 3.5
interstitial collagenase 3.5
indoleamine 2,3-dioxygenase 3.5
lysyl endopeptidase 3.4
prolidase 3.4
plasmin 3.4
matriptase 3.4
sialyltransferase 3.4
TGT 3.4
sialyltransferase 3.4
sialyltransferase 3.4
farnesyltransferase 3.3
aromatic L-amino acid decarboxylase 3.3
ADPase 3.3
proprotein convertase 3.3
CEP 3.3
thromboxane synthase 3.2
15-lipoxygenase 3.2
MTD 3.1
luciferase 3.1
carboxypeptidase B 3.1
prostaglandin synthetase 3.1
PAM 3.1
AMPK 3.1
endothelin-converting enzyme 3.0
DCF 3.0
GTP cyclohydrolase I 3.0
chymase 3.0
GSK 3.0
PARP 3.0
argininosuccinate synthetase 2.9
soluble epoxide hydrolase 2.8
caspase-3 2.8
MAT 2.8
cytosine deaminase 2.8
farnesyltransferase 2.8
alcohol oxidase 2.8
hyaluronidase 2.8
TAT 2.7
TACE 2.7
PAL 2.7
ribonuclease 2.7
ribonuclease 2.7
caspase-9 2.7
thymidine kinase 2.6
proteasome 2.6
caspase-8 2.6
PHD 2.6
arginine deiminase 2.6
MAT 2.6
SPC 2.6
IMP dehydrogenase 2.5
MAP 2.5
firefly luciferase 2.5
histone demethylase 2.5
AMP-activated protein kinase 2.4
PTPase 2.4
collagenase 2.4
nucleotidase 2.4
cathepsin D 2.3
hyaluronidase 2.3
furin 2.3
PAL 2.3
phosphoglycerate kinase 2.3
AMPK 2.2
NADPH oxidase 2.2
thrombin 2.2
cdc2 2.1
TSA 2.1
IKK 2.1
arginase 2.1
DNA methyltransferase 2.1
NADPH oxidase 2.1
tissue plasminogen activator 2.1
heparinase 2.1
pyruvate kinase 2.0
protein kinase 2.0
peroxiredoxin 2.0
LPL 1.9
prostate-specific antigen 1.9
ATP synthase 1.9
lipoxygenase 1.9
NOS 1.9
histidine decarboxylase 1.8
deoxyribonuclease 1.8
RNase 1.8
deoxyribonuclease 1.8
polo-like kinase 1 1.8
apyrase 1.8
CPT 1.7
RNase 1.7
MIP 1.7
protein kinase C 1.7
phosphoglucose isomerase 1.6
aldolase 1.6
CPT 1.6
cathepsin G 1.5
nitrite reductase 1.5
MPP 1.5
nitrite reductase 1.5
transcriptase 1.5
nitrite reductase 1.5
glutaminase 1.5
P-glycoprotein 1.5
trypsin 1.5
phosphofructokinase 1.5
cathepsin L 1.4
kallikrein 1.4
more...
Compound
C25H30N2O5 12.4
dodecyl carbamate 12.4
Convallamaroside 12.4
N-methyl-1-naphthamide 10.8
Dipalmitoylphosphatidic acid 10.8
3-undecanone 10.8
4-undecanone 10.8
Marmesin 10.4
C14H12N4OS 9.8
Vernolide 9.8
Depostat 9.8
Marmesin 9.6
alpha-Chaconine 9.6
1,2,4,5-benzenetetramine 9.4
quinuclidin-3-ol 8.9
2,4-dimethyl-1H-pyrrole 8.9
Benzarone 8.9
C11H16O3 8.8
C5H8N2 8.6
Lariciresinol 8.4
Xanthatin 8.1
Eupafolin 8.1
D-ribose-1-phosphate 8.0
Borrelidin 8.0
Borrelidin 7.9
Xanthatin 7.7
Pristimerin 7.6
Pristimerin 7.6
Pristimerin 7.6
Pristimerin 7.6
Ergosterol peroxide 7.6
Cucurbitacin I 7.6
2-(2-methoxyethoxy)ethanol 7.6
1-piperidinecarboxamide 7.6
Scutellarein 7.6
2,6-piperidinedione 7.6
Anacardic acid 7.5
2,6-piperidinedione 7.5
2-naphthalenesulfonic acid 7.5
Morusin 7.5
MTIC 7.3
Deguelin 7.1
2-Methoxyestradiol 7.0
Genistin 7.0
6-hydroxynicotinic acid 6.9
Wogonin 6.9
Gambogic acid 6.9
6-hydroxynicotinic acid 6.9
Theaflavin 6.9
1-octacosanol 6.8
7H-pyrrolo[2,3-d]pyrimidine 6.8
Brucine 6.7
PKF 6.7
Tetrahydrocurcumin 6.7
Oridonin 6.7
Tricin 6.7
APN 6.7
FUR 6.6
Pimonidazole 6.6
Pimonidazole 6.6
Diosmetin 6.4
Acacetin 6.4
Gadodiamide 6.4
Sepiapterin 6.3
Benzbromarone 6.2
Costunolide 6.2
Cucurbitacin B 6.2
Flubendazole 6.2
Zingerone 6.1
Xanthohumol 6.1
Butein 6.0
Temsirolimus 6.0
Celastrol 6.0
CUE 5.9
Nobiletin 5.9
PGE3 5.8
Dioscin 5.8
Emetine 5.8
Dioscin 5.8
Roxithromycin 5.8
Danshensu 5.7
2-undecanone 5.6
Salinomycin 5.5
Cerivastatin 5.5
Thymoquinone 5.5
2-undecanone 5.5
Harmine 5.4
Indirubin 5.4
Sphingosine 5.4
TEPA 5.4
Oxymatrine 5.4
Usnic acid 5.3
Catalpol 5.3
Quinapril 5.3
Formononetin 5.3
DAPT 5.2
Bufalin 5.1
Lupeol 5.1
EOC 5.0
MBT 5.0
Cyclone 5.0
Bestatin 5.0
Triptolide 5.0
CHM 5.0
celastrol 5.0
Meloxicam 5.0
KIV 4.9
2-cyclopenten-1-one 4.9
Sesamin 4.9
Pterostilbene 4.8
TFC 4.8
Ursolic acid 4.8
Parthenolide 4.7
MDA 4.7
Magnolol 4.6
Epigallocatechin gallate 4.6
1,4,7,10-tetraazacyclododecane 4.6
Acetyl-L-carnitine 4.6
Selectin 4.5
12(S)-HETE 4.5
Parthenolide 4.5
HEP 4.5
Celecoxib 4.5
Ropivacaine 4.5
Naringin 4.5
1H-pyrrole 4.4
1H-pyrrole 4.4
Heparan sulfate 4.4
sebacic acid 4.4
sebacic acid 4.4
HDM 4.4
SCC 4.4
Fisetin 4.4
Gossypol 4.4
Cinnamaldehyde 4.4
Sphingosine 1-phosphate 4.4
Gossypol 4.4
hexuronic acid 4.3
sebacic acid 4.3
Sucralfate 4.3
TEC 4.3
Gemcitabine 4.3
DLG 4.3
SSH 4.3
hexuronic acid 4.3
hexuronic acid 4.3
hexuronic acid 4.2
Gemcitabine 4.2
Chalcone 4.2
6-aminohexanoic acid 4.2
6-aminohexanoic acid 4.2
pyridazine 4.2
pyridazine 4.2
Carcinogen 4.2
Oleanolic acid 4.1
MEE 4.1
TNM 4.1
Honokiol 4.1
Minocycline 4.0
TSC 4.0
more...