Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1519670 (tumor angiogenesis)
 6,052 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
vascular endothelial growth factor 1329
VEGF 674
Mol 498
Sep 391
VEGFR2 322
Vascular endothelial growth factor 279
CD31 237
tyrosine kinase 198
cytokine 181
vascular endothelial growth factor A 180
CD34 161
p53 153
AKT 151
vascular endothelial growth factor receptor 137
mTOR 125
PI3K 105
VEGFR-1 100
collagen 99
endostatin 99
matrix metalloproteinase 97
IL-8 88
KDR 88
ERK 85
platelet-derived 83
vascular endothelial growth factor receptor 2 82
receptor tyrosine kinase 81
MMP-9 80
MMP-2 79
vascular endothelium 78
STAT3 77
ERK1 75
MRI 75
platelet-derived growth factor 74
Bcl-2 74
chemokine 72
cage 69
fibronectin 67
epidermal growth factor receptor 67
HIF-1alpha 65
MAPK 62
p38 61
caspase-3 59
cyclooxygenase-2 59
factor VIII 57
thrombospondin 57
FGF 56
CD105 56
hepatocyte growth factor 56
CXCR4 55
extracellular signal-regulated kinase 54
tumor necrosis factor 53
COX-2 51
IL-6 50
bFGF 50
placental growth factor 47
EGFR 47
TNF 46
CD8 46
VEGF-C 46
epidermal growth factor 45
HIF-1 45
tissue factor 43
PDGF 43
CXCL12 42
urokinase-type plasminogen activator 42
plasminogen 42
colon carcinoma 40
vitronectin 39
osteosarcoma 39
MEK 39
neuropilin-1 38
E-cadherin 38
glycoprotein 38
phosphatidylinositol 3-kinase 38
Tie-2 38
focal adhesion kinase 38
angiopoietin-1 38
heparanase 37
angiogenin 37
JNK 36
IFN 36
CD44 36
Ki-67 36
cyclin D1 35
estrogen receptor 35
von Willebrand factor 35
VEGFR-3 34
MMP9 34
catenin 33
proteasome 33
p21 33
interferon 33
HER2 32
ATP 32
platelet-derived growth factor receptor 32
hemoglobin 32
UTR 32
TGF-beta 31
endoglin 31
Endostatin 31
angiopoietin-2 31
FAK 30
PC-3 30
thrombin 30
c-kit 29
metalloproteinase 29
CD11b 29
insulin 28
inducible nitric oxide synthase 28
cyclooxygenase 28
EGF 28
fused 28
ras 27
thymidine phosphorylase 27
PTEN 27
PDGFR 27
Heparanase 27
proliferating cell nuclear antigen 26
TNM 26
Rho 26
fibrinogen 25
tyrosine kinase receptor 25
mast cell 25
phosphoinositide 3-kinase 25
adhesion molecule 25
c-Met 24
survivin 24
neuropilin 24
signal transducer and activator of transcription 3 24
protein kinase B 24
MVD 24
histone 23
CD4 23
flt 23
IL-10 23
Cytokine 23
nodal 23
membrane-bound 23
semaphorin 22
PLA 22
vimentin 22
ACS 22
IFN-gamma 22
FGF receptor 22
RhoA 22
NMR 22
lectin 22
HGF 21
endoplasmic reticulum 21
PEG 21
Sp1 21
FGF-2 21
Met 20
PARP 20
ubiquitin 20
MMP 20
osteopontin 20
c-Jun 19
TIE2 19
TNF-alpha 19
more...
Disease
tumor angiogenesis 6052
tumor 4239
cancer 3347
tumor growth 1694
tumor progression 709
breast cancer 505
carcinoma 393
metastases 361
tumorigenesis 331
melanoma 296
tumor vasculature 277
hepatocellular carcinoma 249
colorectal cancer 220
carcinogenesis 203
lung cancer 197
prostate cancer 180
glioma 176
adenocarcinoma 154
glioblastoma 146
squamous cell carcinoma 139
renal cell carcinoma 127
lung carcinoma 124
colon cancer 120
non-small cell lung cancer 117
primary tumor 109
ovarian cancer 105
gastric cancer 102
pancreatic cancer 101
solid tumor 99
MCF 67
aggressiveness 64
brain tumor 60
epithelial ovarian cancer 54
ischemia 50
fibrosarcoma 50
Hippel 47
SCID 46
liver cancer 46
glioblastoma multiforme 44
sarcoma 44
cervical cancer 42
lung metastases 42
atherosclerosis 39
bladder cancer 39
osteosarcoma 39
multiple myeloma 38
neuroblastoma 37
lymphoma 37
mammary tumor 36
hypertension 35
Hepatocellular carcinoma 35
lymphatic vessels 35
leukemia 35
mimicry 33
cornea 32
liver cancer 31
tumor initiation 29
renal cancer 29
Blocking 28
Glioblastoma 27
metastatic breast cancer 25
liver metastases 25
Kaposi's sarcoma 25
rheumatoid arthritis 24
obesity 22
Melanoma 22
adenoma 21
endometrial cancer 21
diabetes 21
HGF 21
retinopathy 19
suicide 19
head and neck cancer 18
acute myeloid leukemia 17
arthritis 17
metastatic renal cell carcinoma 17
oral cancer 17
sepsis 16
retinoblastoma 16
EMT 16
dysplasia 16
sepsis 16
diabetic retinopathy 16
skin cancer 15
cancer angiogenesis 14
mesothelioma 14
small cell lung cancer 13
herpes simplex 13
proteinuria 13
astrocytoma 12
hematologic malignancies 12
metastatic melanoma 12
stroke 12
esophageal cancer 12
B-cell lymphoma 12
CAM 12
HCC 12
psoriasis 12
hepatitis B 11
SDS 11
chondrosarcoma 11
vascular disease 11
esophageal cancer 11
neoplastic transformation 10
meningioma 10
DDP 10
macular degeneration 10
brain metastases 10
Tag 10
carcinomatosis 10
aggression 10
stromal tumors 10
bone metastases 10
NOD 10
infectious diseases 10
neuroendocrine tumor 9
cardiovascular disease 9
gliosarcoma 9
ductal carcinoma 9
thyroid cancer 9
cold 9
cutaneous melanoma 9
malignant ascites 8
non-Hodgkin's lymphoma 8
coronary artery disease 8
Dukes 8
medullary thyroid carcinoma 8
angiosarcoma 8
Colon 8
sarcoma 180 8
Alzheimer's disease 8
blindness 8
Colon 8
uterine cervix 8
Colon 8
cancer recurrence 8
malignant pleural effusion 7
residual disease 7
childhood cancer 7
choriocarcinoma 7
Neuroblastoma 7
NAME 7
ductal carcinoma in situ 7
Infection 7
Hodgkin's disease 7
PCL 7
Ewing's sarcoma 7
cytomegalovirus 7
Neuroblastoma 7
Adenovirus 6
brain cancer 6
acute lymphoblastic leukemia 6
invasive cancer 6
epithelial tumor 6
Adhesion 6
plaque 6
gastrointestinal cancer 6
TEM 6
intracranial tumors 6
hemangioma 6
more...
Symptom
pain 14
starvation 14
diarrhea 10
collapse 7
nausea 7
fatigue 6
cachexia 5
vomiting 4
anesthesia 4
hypercapnia 4
seizures 4
hemoptysis 3
headache 3
hyperoxia 2
analgesia 2
overweight 2
asthenia 2
night sweats 1
ataxia 1
rigors 1
erythema 1
splenomegaly 1
Scratch 1
dyspnea 1
rundown 1
dry skin 1
pelvic pain 1
apathy 1
constipation 1
exhaustion 1
rhinorrhea 1
thinning 1
sneezing 1
flushing 1
functional recovery 1
skin damage 1
acidity 1
anorexia 1
skin irritation 1
cancer pain 1
productive cough 1
decreased appetite 1
chills 1
weakness 1
respiratory distress 1
Flu-like symptoms 1
hepatosplenomegaly 1
nausea and vomiting 1
Drug
Bevacizumab 86
Sorafenib 29
IFN-gamma 22
lysine 21
Dermatol 19
CSF 16
ROS 15
Cardiovasc 15
Paraffin 13
CAM 12
uPA 10
Monit 9
IL-2 9
MAP 8
vitamin E 7
Imatinib 6
CoCl2 6
CoCl2 6
Cetuximab 5
Docetaxel 5
Taxol 5
Gefitinib 5
Gleevec 5
G-CSF 5
NADH 5
CTX 5
Arsenic trioxide 5
Retinoic acid 4
Gel 4
Irinotecan 4
Bortezomib 4
Gelatin 4
Erlotinib 4
ICI 4
BH4 4
RFP 4
2-Methoxyestradiol 4
Nexavar 4
Adriamycin 4
Activin 4
Cilengitide 4
Taxotere 3
Lovastatin 3
CTT 3
Axitinib 3
TAT 3
Vandetanib 3
ETS 3
Indomethacin 3
Arresten 3
Tarceva 3
TAK 3
Fragment 3
p75 3
Herceptin 3
IFN-beta 3
KGF 2
Optison 2
Marimastat 2
Urokinase 2
Prednisolone 2
Bestatin 2
Sunitinib malate 2
Albumin 2
CTX 2
Estrogens 2
Oxaliplatin 2
Itraconazole 2
CPT-11 2
G418 2
Simvastatin 2
EE2 2
NVP 2
Ginseng 2
Serum albumin 2
Bayer 2
GEO 2
Gelfoam 2
CTX 2
Angiotensin II 2
Asn 2
DMSA 2
lactose 2
Optison 2
Meth 2
Semaxanib 2
Doxycycline 2
Pemetrexed 2
Sonazoid 2
Captopril 2
Nephron 2
Pravastatin 2
Azithromycin 2
caffeine 2
Tocilizumab 1
Everolimus 1
TTC 1
FAD 1
Zoledronic acid 1
Vinorelbine 1
IL-11 1
Hyaluronidase 1
Norplant 1
Masoprocol 1
Cimetidine 1
Histamine 1
Protamine sulfate 1
Romidepsin 1
Iopamidol 1
CTC 1
Intal 1
Nimesulide 1
AMC 1
Cimetidine 1
Abciximab 1
Etoposide 1
Epigallocatechin 1
ROC 1
TAC 1
Sucralfate 1
Mutagen 1
Bifidobacterium 1
Artesunate 1
ascorbate 1
Leucovorin 1
Plaunotol 1
Ranitidine 1
TES 1
Emodin 1
Vatalanib 1
DDAVP 1
CCL 1
Nitric Oxide 1
beta-Galactosidase 1
Glycyrrhiza 1
Omniscan 1
Glide 1
Tranilast 1
DDAVP 1
ABC 1
BLM 1
EPA 1
ADM 1
Silica 1
Verteporfin 1
DHT 1
Zoledronic acid 1
Onconase 1
Vorinostat 1
Lenalidomide 1
Gliadel 1
Carbenoxolone 1
Ezetimibe 1
Tecogalan sodium 1
Myricetin 1
CTC 1
LMWH 1
Barium sulfate 1
Clodronate 1
DEX 1
more...
Enzyme
ERK 486
mitogen-activated protein kinase 249
focal adhesion kinase 109
luciferase 63
protein kinase 62
MEK 54
urokinase-type plasminogen activator 49
caspase-3 48
phosphatidylinositol 3-kinase 38
proteasome 34
protein kinase C 30
thrombin 29
phosphoinositide 3-kinase 25
MMP 24
thymidine phosphorylase 24
trypsin 22
ACS 22
CD13 20
PARP 20
collagenase 18
plasmin 18
tryptase 16
matrix metalloproteinase 9 14
AMP-activated protein kinase 13
reverse transcriptase 12
cathepsin B 12
RNase 11
AMPK 11
RNase 11
GSK 10
AMPK 10
prolyl hydroxylase 10
TSP-1 9
NADPH oxidase 9
NADPH oxidase 9
MMP-3 9
thymidine kinase 9
caspase-9 9
tissue plasminogen activator 9
MAP 8
catalase 8
matrix metalloproteinase 2 8
ribonuclease 8
ribonuclease 8
RNA polymerase 8
peroxidase 8
caspase-8 8
NO synthase 7
renin 7
P-glycoprotein 7
APC 7
alkaline phosphatase 7
cdc2 7
calcineurin 6
lipoxygenase 6
hyaluronidase 6
hyaluronidase 6
phospholipase C 6
beta-galactosidase 6
prostate-specific antigen 5
12-lipoxygenase 5
PDK1 5
transcriptase 5
NOS 5
ATP synthase 5
ATPase 4
IKK 4
pyruvate kinase 4
DNA methyltransferase 4
cathepsin D 4
superoxide dismutase 4
complex I 4
prostate-specific membrane antigen 4
soluble epoxide hydrolase 3
kallikrein 3
MIP 3
glutathione S-transferase 3
DCF 3
glutathione peroxidase 3
sialyltransferase 3
lysyl oxidase 3
indoleamine 2,3-dioxygenase 3
sialyltransferase 3
sialyltransferase 3
legumain 3
thromboplastin 3
phospholipase A2 3
firefly luciferase 3
furin 3
carbonic anhydrase 3
PAM 3
arginase 3
SPC 3
prostaglandin synthetase 3
guanylate cyclase 3
lactate dehydrogenase 3
ACE 3
TAT 3
aldehyde dehydrogenase 2
interstitial collagenase 2
chymase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
phosphofructokinase 2
BMA 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
farnesyltransferase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
SCP 2
PAL 2
peroxiredoxin 2
aldolase 2
proprotein convertase 2
heme oxygenase 2
CPT 2
glyceraldehyde-3-phosphate dehydrogenase 2
CEP 2
topoisomerase 2
15-hydroxyprostaglandin dehydrogenase 2
pepsin 2
phosphoglycerate kinase 2
endonuclease 2
15-lipoxygenase 2
HCS 2
protein farnesyltransferase 2
CEP 2
3-mercaptopyruvate sulfurtransferase 2
succinate dehydrogenase 2
MAT 2
CPT 2
topoisomerase 2
sphingosine kinase 2
chitinase 2
PAL 2
MAT 2
tyrosine hydroxylase 2
CPT 2
farnesyltransferase 2
nicotinamide phosphoribosyltransferase 2
CAD 1
CAD 1
glyceraldehyde-3-phosphate dehydrogenase 1
heparinase 1
TGT 1
uridine phosphorylase 1
carboxypeptidase E 1
seryl-tRNA synthetase 1
MDR 1
PHD 1
IMP dehydrogenase 1
cathepsin L 1
PKG 1
cancer procoagulant 1
neutrophil elastase 1
prolidase 1
deoxyribonuclease 1
hypoxanthine-guanine phosphoribosyltransferase 1
uracil phosphoribosyltransferase 1
more...
Compound
Dec 422
Clin 257
oxygen 253
DNA 223
tyrosine 190
MDA 118
arginine 73
water 62
sulfate 50
nitric oxide 49
Asp 47
TNF 46
phosphate 45
MTT 42
glucose 40
MEK 39
PEG 39
methionine 39
calcium 35
cysteine 33
ATP 32
PEG 32
Gly 30
serine 30
iron 27
lysine 26
TNM 26
leucine 25
acetate 24
ethanol 24
copper 24
ACS 23
ACS 22
sodium 21
ASA 19
hydrogen 18
PGE2 17
aspartic acid 17
aspartic acid 17
His 17
aspartic acid 17
aspartic acid 17
threonine 16
alanine 15
iodine 15
CAM 14
nitrogen 13
5-FU 13
SCC 13
urea 12
cAMP 12
bromide 12
H2O2 11
SDS 11
Sphingosine 11
zinc 11
galactose 11
pyrimidine 10
Neo 10
PMA 10
pyrimidine 10
AMP 10
APN 9
DTPA 9
selenium 9
NH2 9
cobalt 9
Adriamycin 9
Heparin 9
Phe 9
Curcumin 8
MAP 8
dUTP 8
Rapamycin 7
retinoic acid 7
quinoline 7
cGMP 7
anthracene 7
quinoline 7
GTP 7
TEM 7
formaldehyde 7
DDP 7
PLA 7
proline 7
COS 7
Angiotensin II 7
Gemcitabine 6
glycerol 6
glutamine 6
Pac 6
Lactate 6
vitamin D 6
PGE 6
Gemcitabine 6
ADR 6
H2S 6
COX 6
N-acetylcysteine 6
hyaluronic acid 6
Vimentin 5
tryptophan 5
nickel 5
THP 5
Hoechst 33342 5
pyrrolidine 5
Wogonin 5
tryptophan 5
CTX 5
PEI 5
25-dihydroxycholecalciferol 5
methanol 5
chloroform 5
glutamate 5
pyrrolidine 5
ATF 5
Thrombin 5
Heparan sulfate 5
NADH 5
tryptophan 5
salt 5
Epigallocatechin gallate 5
THP 5
PEI 5
Cysteine 5
DAPT 5
tryptophan 5
Phosphatidylinositol 5
Genistein 5
1,4,7,10-tetraazacyclododecane 4
Collagen 4
MTS 4
Estrogen 4
noradrenaline 4
Celecoxib 4
Tyrosine 4
Histone 4
asparagine 4
Fibrin 4
Paclitaxel 4
PAM 4
Thyroid 4
glutamic acid 4
Celastrol 4
ethyl acetate 4
Metformin 4
Oridonin 4
GM3 4
Ile 4
2-Methoxyestradiol 4
NAD 4
Metformin 4
MIA 4
Melatonin 4
MBT 4
DBA 4
celastrol 4
Insulin 4
barium 4
Pluronic 4
more...