Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1519670 (
tumor angiogenesis
)
6,052
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tumor growth depends on angiogenesis, the growth of new blood vessels.
Complement factor H
(
CFH
) is a plasma glycoprotein that functions as a regulator of the complement system. The aim of this study is to delineate the role of
CFH
in angiogenesis. A conditional null allele of the
Cfh
gene was generated in C57BL/6J mice by flanking the exon 3 with
loxP
sites. The
Cfh
flox/flox
mice were crossed with
Rosa26-Cre
mice to obtain the mice homozygotes of
Cfh
deletion (
Cfh
-/-
). The
Cfh
-/-
mice were examined by
in vivo
angiogenesis assays. Mouse endothelial cells were treated with media containing 5% of mouse plasma from the wildtype or
Cfh
-/-
mice and assayed for proliferation, viability and migration. The
Cfh
-/-
mice did not display any obvious abnormalities. They demonstrated a pro-angiogenic phenotype in matrigel plug assay, but not in aorta ring assay.
In vitro,
loss of Cfh in plasma does not affect proliferation or viability, but significantly increases migration of mouse endothelial cells. Our findings suggest that plasma
CFH
inhibits angiogenesis by reduction of endothelial cell migration. Thus the mutation of
CFH
might lead to excessive
tumor angiogenesis
.
...
PMID:Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration. 2881 20
