Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1519176 (
PSA
)
5,490
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A new prognostic score called the cell cycle progression or
CCP
score has been evaluated for predicting outcome in men with prostate cancer. The score is based on 31 cell cycle progression genes and 15 housekeeper control genes. Results on 5 cohorts have been reported. In all cases the
CCP
score was strongly predictive of outcome both in univariate models and in multvariate models incorporating standard factors such as Gleason grade,
PSA
levels and extent of disease. Two cohorts evaluated patients managed by active surveillance where the outcome was death from prostate cancer, two cohorts examined patients treated by radical prostatectomy where biochemical recurrence was the primary endpoint, and one smaller cohort looked at patients treated with radiotherapy where again biochemical recurrence was used as the endpoint. In all cases a unit change in
CCP
score was associated with an approximate doubling of risk of an event. These data provide strong event to support use of the
CCP
score to help guide clinical management.
...
PMID:Prognostic value of a cell cycle progression score for men with prostate cancer. 2453 87
