Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1519176 (PSA)
 5,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical efforts to spare bladder function even in the case of muscle invasive recurrent bladder cancer is taking. Early detection of recurrence is essential for bladder sparing, and both urinary NMP22 and BTA are thought to have potency to detect recurrence of bladder cancer earlier than urinary cytology. Intravesical administration of BCG for superficial bladder cancer and intraarterial injection of chemoagents (Methotrexate and Cisplatin) with radiation for muscle invasive bladder cancer are thought to play important roles in sparing the bladder. Early detection of recurrent prostate cancer is becoming easier by ultrasensitive PSA assay. Though the value of early detection of recurrence is not proven since the benefits of early hormonal treatment have not yet been established, that should be a good indicator to evaluate new and coming treatments and play a important role to develop an effective treatment for recurrent prostate cancer.
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PMID:[Recurrent urological cancer--diagnose and treatment]. 949 27

The authors report the diffusion and contrast-enhanced MRI appearance of five cases of granulomatous prostatitis (GP), non-specific (two cases) and infectious post-Bacillus Calmette-Guerin (BCG) therapy (three cases, with a tubercular abscess in two of them). All patients had raising PSA levels and abnormal DRE. History of BCG therapy or acute prostatitis was present in four patients. Multiparametric MRI (T2W-MRI, DW-MRI and DCE-MRI) was performed before biopsies. Diagnosis was confirmed by TRUS-guided biopsies in four cases and by transurethral resection in one case. MRI showed a tumor-like appearance in three cases, an abscess-like appearance in one case and a combined tumor/abscess-like appearance in one case. Extraprostatic fat was infiltrated in three patients, simulating T3a disease. Histologically, caseous necrosis was found when MRI showed abcedation. Demonstration of occult tubercular abscesses in post-BCG GP may have therapeutic implications and MRI is useful prior to surgical or interventional drainage of large caseous abscesses.
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PMID:Multiparametric MRI features of granulomatous prostatitis and tubercular prostate abscess. 2307 51

The aim of this paper was to review the risk and incidence of urological malignancies and the clinical characteristics and outcomes of renal transplant urological malignancies. Medline/PubMed from January 1980 to February 2013 was searched to identify all medical literature about native kidney, graft bladder and prostate cancers. Comparing to general population, risk of kidney cancer was found to be 7 to 10 times greater and most of them are incidental low-stage, low-grade tumors with a good prognosis. Open and laparoscopic radical nephrectomies without lymph nodes dissection were reported to be safe. Incidence of graft RCC was 0.19%. Papillary carcinomas represented more than 50% of de novo graft carcinomas, which seemed to be low-grade carcinomas with good prognosis. Risk of prostate cancer was two times higher. Open or laparoscopic radical prostatectomy is safe and feasible for management of localized prostate cancer in patients with kidney allograft. Upper urinary tract (UUT) transitional cell carcinoma (TCC) incidence was reported between 0.7% and 3.8%. Reports suggested a 3-fold increased risk of developing bladder TCC. Intravesical BCG in superficial bladder cancer and/or CIS is a valid option. For invasive urothelial tumor, radical cystectomy in renal transplant patients remains the best treatment. Oncological outcomes of urological cancers in renal transplant recipients are good and conservative treatment should be preferred each time it is feasible to prevent returning to dialysis following recommendations of urological cancer treatment. Close monitoring of renal transplant recipient must be performed with at least an abdominopelvic US and PSA measurement once a year.
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PMID:Urological tumors in renal transplantation. 2472 41

Intravesical BCG therapy after transurethral resection of bladder tumor (TURB) is considered the most effective treatment for prophylaxis against the recurrence of high risk non-muscle invasive bladder cancer, and generally well tolerated and infectious complication are rare. We reported a case of granulomatous prostatitis is a patient who had undergone intravesical BCG therapy due to non-invasive superficial urothelial carcinoma of bladder. This patient was diagnosed by prostate biopsy because of PSA elevation without any other voiding symptoms and abnormal abscess pocket in transrectal ultrasonography.
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PMID:Treatment experience for incidentally diagnosed asymptomatic prostate tuberculosis in a patient with history of BCG intravesical therapy. 2954 83