Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1510475 (diverticular disease)
 2,138 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the potential effect of androgens on human colorectal cancer, the prevalence and concentration of cytosolic androgen receptors were analyzed in 23 rectal and 13 cecal adenocarcinomas by a hybrid radioligand assay. Androgen receptors were detected in nine of the rectal (39 percent) and five of the cecal tumors (38 percent). Androgen receptor levels demonstrated were low, ranging from three to 17 fmol/mg cytosol protein. Dissociation constants were 1 nM or less. The presence of androgen receptors was independent of age or sex of the patient, and of the state of histologic differentiation and Dukes' staging of the tumor. Androgen receptor prevalence was similar in mucosa adjacent to rectal and cecal adenocarcinomas and in mucosa from five of ten patients (50 percent) with diverticular disease. Our findings suggest that androgen dependency does not play a major role in endocrine control of the development of rectal cancer.
Dis Colon Rectum 1986 Feb
PMID:Androgen receptors in rectal and colonic cancer. 394 28

Sigmoid diverticulitis with perforation and generalized peritonitis is a grave complication of diverticular disease. To compare accurately the results of two operative approaches--proximal colostomy with drainage and proximal colostomy with resection or exteriorization--the authors assessed the clinical and pathologic features of 121 consecutive patients with perforating sigmoid diverticulitis. There were no differences between treatment groups in age, sex, mean duration of symptoms, clinical presentation, number of coexistent diseases, type of peritonitis or chronic corticosteroid use. Overall mortality for emergency operation was 12 percent. Mortality was significantly greater (P less than 0.05) among the 31 patients treated by colostomy and drainage (26 percent) than among the 90 patients treated by colostomy and resection or exteriorization (7 percent). Seven of the nine patients who died from persistent sepsis had undergone colostomy and drainage. Four clinical factors were found to be predictive of mortality (P less than 0.05): persistent postoperative sepsis, fecal peritonitis, preoperative hypotension, and prolonged duration of symptoms. These factors identified a subgroup of patients who, because of an increased risk of death, would be likely to benefit from the more complete eradication of the septic focus that is achieved by colostomy and resection.
Dis Colon Rectum 1985 Feb
PMID:Sigmoid diverticulitis with perforation and generalized peritonitis. 397 9

One hundred forty patients who had complicated diverticular disease were identified in a retrospective review at the Lahey Clinic between 1967 and 1982. Of these patients, 86 underwent resection with primary anastomosis with a 1 percent mortality rate and an 18 percent morbidity rate; 13 had resection with anastomosis and creation of a proximal colostomy with no death and a 22 percent morbidity rate; 19 had the Hartmann operation or colostomy with mucous fistula with a 16 percent mortality rate and a 23 percent morbidity rate; and 22 underwent a traditional three-stage operation with 14 percent mortality and 24 percent morbidity rates. The average duration of hospitalization was 21 days for patients who underwent the one-stage procedure, 31 and 39 days for those who had a two-stage operation, and 52 days for patients who underwent the three-stage procedure. Primary resection for complicated disease is associated with acceptable morbidity and mortality rates under appropriate circumstances.
Dis Colon Rectum 1985 May
PMID:Surgical management of complicated diverticulitis. The Lahey Clinic experience, 1967 to 1982. 399 47

In a retrospective evaluation of 1244 consecutive barium enemas performed at two hospitals over a five-year period (1979 to 1984), colonic diverticula were found in 177 (14.2 percent). The prevalence among the Ashkenazi Jews was 19.7 percent, among the Sephardi and Oriental Jews, 16 percent, and among the Arabs, 9.5 percent. Comparing these figures with the results of a similar study performed ten years ago, it becomes obvious that the prevalence of diverticular disease in the Ashkenazi group remained the same, while there was a three-fold increase among Sephardi and Oriental Jews, and a seven-fold increase among Arabs. It is postulated that, in less than one generation, diverticular disease will be equally frequent among all ethnic groups in Israel.
Dis Colon Rectum 1985 Jun
PMID:The changing epidemiology of diverticular disease in Israel. 400 37

In five patients, rectal bleeding was ascribed to a patchy or diffuse mucosal colitis affecting the sigmoid colon only. The patients all had well marked localized sigmoid diverticular disease. The histologic features were nonspecific, without any changes suggestive of Crohn's disease. One patient had a short, self-limited illness, whereas the others had continuing illnesses lasting at least six months. In one patient who underwent sigmoid colectomy, the inflammatory features had disappeared, probably in response to sulphasalazine therapy. It is suggested that this syndrome may be a complication of the muscular disorder that underlies the formation of colonic diverticula.
Dis Colon Rectum 1984 Aug
PMID:Is segmental colitis a complication of diverticular disease? 614 39

Five hundred fifty-six barium enema examinations performed in male and female patients (aged 20--70+ years) were studied retrospectively to estimate the prevalence of colonic diverticulosis in southern Iran. The frequency of diverticulosis in all subjects above the age of 20 years was 1.6 per cent, in persons above the age of 50 years, 2.4 per cent, and in persons below the age of 50 years, 1.2 per cent. This is in marked contrast to the high prevalence of the disease in Western countries, e.g., the 20 per cent overall prevalence in the United States. The high dietary fiber intake of the Iranian people may explain the rarity of the disease in Iran.
Dis Colon Rectum
PMID:Prevalence of colonic diverticular disease in southern Iran. 626 88

Of 615 patients with diverticular disease of the colon, 429 had diverticula in the cecum and ascending colon, 98 in the sigmoid and descending colon and 88 in both the right- and left-side colon. The right-sided type was more common in younger people and more predominant in men, whereas the left-sided type was more common in the elderly and showed no difference in numbers between men and women. More than 50 per cent of patients were asymptomatic and 25 per cent complained of disturbed bowel function. The frequency of diverticulitis was not related to location, but to the number of diverticula. Seventy-seven were complicated by acute inflammation (right-sided diverticulitis, 61, and left-sided diverticulitis, 16). Many patients with right-sided diverticulitis improved with medical treatment and the operative procedure of choice was drainage of the inflamed area with supplemental appendectomy.
Dis Colon Rectum 1984 Aug
PMID:Diverticular disease of the colon in Japan. A review of 615 cases. 646 90

Two Turkish populations, one with an urban background and the other rural, were compared in regard to their colonic function. Rural subjects consume a diet with higher fiber than urban people in Turkey. The rural group had a greater daily fecal output, faster intestinal transit, and lower intraluminal pressure, with a greater output of calcium in the feces than those living in an urban area in Turkey. The effects are similar to those described when fiber is added to the diet. Urban dwellers in Turkey who lack these effects are said to have a rising incidence of fiber-related diseases of the colon, such as diverticular disease.
Dis Colon Rectum 1984 Aug
PMID:Colonic function in rural and urban populations of Turkey. 646 91

Giant colonic diverticulum is an uncommon complication of diverticulosis, with only 52 previously reported cases. Complications secondary to the giant air cysts occurred in only six instances, and all but one occurred in the sigmoid colon. Two additional cases are described, presenting atypical location, age, and complication by pneumoperitoneum.
Dis Colon Rectum 1984 Aug
PMID:Unusual manifestations of giant colonic diverticulum. 646 93

The surgeon is frequently confronted with the problem of how much colon to resect when operating on patients with colonic diverticulosis or diverticulitis. Two questions arise: will diverticulosis progress in the proximal colon if only the sigmoid is removed, and will diverticulitis recur in the more proximal diverticula? To evaluate these potential problems, the histories were reviewed of 61 patients who had elective sigmoid resection for diverticular disease and who had barium enema examinations before operation, early during the postoperative period, and at least five years later. Progression of diverticulosis was noted in only nine (14.7 per cent) patients on repeat barium-enema examination five to nine years after resection; the progression was noted to be minimal in all nine. Seven patients (11.4 per cent) had signs and symptoms of recurrent diverticulitis. Only three patients demonstrated progression of diverticulosis and recurrent diverticulitis. We see no benefit in resecting all of the diverticula-bearing colon after adequate sigmoid resection, as there is minimal progression in the diverticular process and the risk of recurrence is low.
Dis Colon Rectum 1984 Oct
PMID:Influence of sigmoid resection on progression of diverticular disease of the colon. 648 70


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