Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1389183 (autodigestion)
 317 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Evidence is presented indicating that mouse thymus, spleen, kidney, lung and heart contain a protease activity with relatively high specificity for histones. It is suggested that degradation of chromatin occurring in irradiated lymphoid tissues is produced by the action of alkaline endonuclease in association with this histone protease. The autodigestion of chromatin was assessed by determining the release of soluble chromatin from cells suspended in sucrose media of low ionic strength. It was found that the protease inhibitors, phenylmethylsulphonyl fluoride and especially NaHSO3, were also capable of depressing the activity of alkaline endonuclease, the fragmentation of chromatin, and the release of soluble chromatin. The results suggest that the release of histones from irradiated lymphoid tissues cannot be considered as a determinant step in the fragmentation of DNA in chromatin.
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PMID:Autodigestion of chromatin in some radiosensitive and radioresistant mouse cells. Role of proteolysis and endonucleolysis. 626 62

A number of facts suggest that chromatin autodigestion, occurring in the early phase of apoptosis, is carried out by an enzymatic system, composed of an endonuclease and a protease, which yields oligonucleosomic chromatin fragments. Though this enzymatic system appears to be present in most mammalian cell nuclei, radiation-induced apoptosis takes place, with a high frequency, only in cell populations having less well-developed nuclear matrices, such as lymphoid cells. Moreover, apoptosis seems to occur in a different manner in cells with less well-developed nuclear matrices (radiosensitive cells) compared with cells that contain dense nuclear matrices (radioresistant cells). Thus, dying lymphocytes progressively release their degraded chromatin from nuclei, without displaying the cellular budding and formation of apoptotic bodies. Nevertheless, apoptosis remains the main cause of cell death and cell depletion in irradiated lymphoid tissues. In contrast, the process of cellular budding and formation of apoptotic bodies appears to be specific for cells having well-developed nuclear matrix, such as those from small intestine and liver. However, in these tissues the frequency of apoptosis is relatively low and cannot be considered as the main cause of radiation-induced tissue involution.
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PMID:Cellular death by apoptosis in some radiosensitive and radioresistant mammalian tissues. 631 89

Surgery of pancreatic and biliary tract carcinomas includes an extensive surgical dissection with removal of all neural and lymphoid tissue together with a skeletonization of hepatoduodenal structures. Skeletonization or autodigestion may lead to pseudaneurysms of perihepatic arteries. Rupture of one of these aneurysms may cause a severe upper gastrointestinal bleeding. Only a few cases of these serious complications are reported in literature.
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PMID:[Massive gastrointestinal hemorrhage with anastomosis rupture in pseudoaneurysm of the common hepatic artery follow pancreaticoduodenectomy. An unusual, severe complication]. 1297 78