Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1384489 (
Scratch
)
395
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Junctional adhesion molecule B
(
JAM-B
) is a multifunctional transmembrane protein that plays an important role in tumor progression.
JAM-B
is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression and metastasis of colorectal cancer. The inconsistency of the results in different cancers has led to uncertainty regarding the role of
JAM-B
in carcinogenesis. For this purpose, the expression levels of
JAM-B
in pancreatic cancer (PanCa) tissues were associated with T stage and lymph node involvement with significant differences. A relatively high expression of
JAM-B
was found in PanCa cell lines by immunohistochemistry and western blot analysis. By cell transfection,
JAM-B
was silenced in tumor cell lines to determine cell invasion and migration abilities.
Scratch
wound assays and Transwell assays revealed that shJAM-B significantly decreased Panc-1 cell migration and invasion. Experiments were also conducted using a subcutaneous PanCa nude mouse model. A significant difference in tumor diameter at the injection site was found between the control group and the
JAM-B
low expression group. The expression levels of c-Src and MMP9 were also significantly reduced compared to that in the control group by immunohistochemistry. In conclusion, our results suggest that
JAM-B
secreted by cancer cells can promote progression and invasion in PanCa by upregulating the c-Src signal and related downstream proteins.
...
PMID:The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer. 3223 30
