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Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C1384489 (
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)
395
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The ces-1 and ces-2 genes of C. elegans control the programmed deaths of specific neurons. Genetic evidence suggests that ces-2 functions to kill these neurons by negatively regulating the protective activity of ces-1, ces-2 encodes a protein closely related to the vertebrate
PAR
family of bZIP transcription factors, and a ces-2/ces-1-like pathway may play a role in regulating programmed cell death in mammalian lymphocytes. Here we show that ces-1 encodes a Snail family zinc finger protein, most similar in sequence to the Drosophila neuronal differentiation protein
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. We define an element important for ces-1 regulation and provide evidence that CES-2 can bind to a site within this element and thus may directly repress ces-1 transcription. Our results suggest that a transcriptional cascade controls the deaths of specific cells in C. elegans.
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PMID:The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. 1051 12
