Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1332347 (ADH)
 2,230 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the first experimental series, 10 healthy male test subjects with a high susceptibility to motion sickness showed a significant increase of ACTH, cortisol, STH, prolactin, ADH, aldosterone concentrations, and plasma renin activity after vestibular tests. The 10 subjects with a moderate susceptibility exhibited a still higher increase of the hormones, except plasma renin. The 8 test subjects with a low susceptibility displayed a considerable increase in ACTH, cortisol, and STH after vestibular stimulation. In the second experimental series, the increase of STH, cortisol, ADH, aldosterone and renin occurred immediately after rotation in the moderate susceptibility subjects and an hour after exposure in the high susceptibility subjects. This may be indicative of specific immediate adaptation mechanisms or excitation transfer in the CNS in high susceptibility persons. In the third experimental animal series, the permeability of the blood-brain barrier for 125I and IgG increased after rotation. Greater concentrations of potassium, chloride, and urea in CSF are suggestive of an inhibition process activation in the CNS and, probably, of an active urea transport by the vascular plexus epithelium which maintains constant osmotic pressure of cerebral extracellular fluid and prevents hyper-hydration of CNS neurons.
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PMID:Hormonal status and fluid electrolyte metabolism in motion sickness. 337 37

Paraneoplasia has come to denote those tumor activities not caused within an organism directly by invasion, obstruction, or by the tumor burden itself. PSN research has yielded best results through the examination of those hormones produced by the tumor, esp. the pro-ACTH and its functionally active subgroups, furthermore the ADH, gonadotropins, HPL, STH, prolactine etc. Frequently very special features have been found to characterize this disease which have been published in detail. In addition to this, several differentiating PNS have been described without having been sufficiently defined, esp. those concerning the nervous system, the haematopoesia , the kidneys, the skin and the gastrointestinal system. In very rare cases there has been a mention or different characteristic syndromes that have come to be assigned to special kinds of tumors.
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PMID:[Paraneoplastic syndromes]. 637 41