Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1332347 (ADH)
 2,230 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vestigial wing and wild type populations of Drosophila melanogaster were exposed to 5%, 20%, and 60% oxygen at normal atmospheric pressure. Adult mortality rates, larval production, and allele frequency changes in four gene-enzymes were examined in the populations. All flies in 60% oxygen survived as well as controls until day 20 and then died out within the next 10 to 12 d. In 5% oxygen, vestigial wing flies had mortality rates greater than the 20% controls initially, but the rate eventually approached that of the controls. Wild type flies in 5% oxygen survived as well as controls. Larval production and rate of eclosure in 60% oxygen were similar to controls, but reduced in 5% oxygen. Allele frequency shifts to 6-phosphogluconate dehydrogenase and phosphoglucomutase were observed in 5% oxygen, and a shift of alpha-glycerophosphate dehydrogenase allele frequencies occurred in 60% oxygen. There was no evidence of in vivo inactivation of ADH, 6-PGD, alpha-GPD or PGM in 60% oxygen.
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PMID:Survivorship and gene frequencies of Drosophila melanogaster populations in abnormal oxygen atmospheres. 81 44

A biochemical study has been made of the effects of low doses of alpha chlorohydrin on all the glycolytic enzymes and two key enzymes of phosphogluconate pathway i.e. glucose-6-phosphate dehydrogenase (G-6-PDH) and 6-phosphogluconate dehydrogenase (6-PGDH) of rat testis and epididymis. All the glycolytic enzymes of testis and epididymis are decreased after treatment with alpha chlorohydrin. G-6-PDH and 6-PGDH are decreased only in epididymis and not in the testis. LDH, ADH and glucose-6-phosphatase were also studied histochemically to show that the drug affects the glycolytic enzymes of epididymal cells and various testicular cell types of testis. Possible significance of these results is discussed.
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PMID:Effect of low doses of alpha chlorohydrin on the enzymes of glycolytic and phosphogluconate pathways in the rat testis and epididymis. 626 79