Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1323099 (
sympathomimetic
)
2,957
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function.
Rad
is a monomeric G-protein that interacts with LTCC. Genetic deletion of
Rad
(
Rad
-/-
) renders LTCC in a
sympathomimetic
state. The study goal was to use a clinically inspired pharmacological stress echocardiography test, including analysis of global strain, to determine whether
Rad
-/-
confers tonic positive inotropic heart function. Sarcomere dynamics and strain showed partial parallel isoproterenol (ISO) responsiveness for wild-type (WT) and for
Rad
-/-
.
Rad
-/-
basal inotropy was elevated compared to WT but was less responsiveness to ISO.
Rad
protein levels were lower in human patients with end-stage non-ischemic heart failure. These results show that
Rad
reduction provides a stable inotropic response rooted in sarcomere level function. Thus, reduced
Rad
levels in heart failure patients may be a compensatory response to need for increased output in the setting of HF.
Rad
deletion suggests a future therapeutic direction for inotropic support.
...
PMID:Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. 2779 60
