Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1323099 (sympathomimetic)
 2,957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In normal subjects, forced inspiration may dilate the bronchi and be considered as a defence or compensatory reaction in certain cases. In asthma, forced inspiration has the opposite effect. Bronchospasm occurs or becomes worse, usually moderately and transiently, but sometimes to a marked and lasting degree. These reactions may be prevented by anticholinergic and sympathomimetic drugs. They should be avoided and one should thus prohibit the manoeuvres which trigger them off. One should take them into consideration during respiratory function tests. This paradoxical effect of forced inspiration seems to exist to various degrees in most asthmatic patients, it may be considered as a diagnostic sign of asthma.
Sem Hop 1976 Jan 23
PMID:[Paradoxical effect of forced inspiration: a new characteristic of asthmatic disease?]. 18 34

A patient with a toxic adenoma, already reduced in size by TSH, presented on the third day after treatment of a common cold by phenylpropanolomine, a severe pain in the thyroid gland. 4 weeks later, the nodule, which measured 3 x 4 cm. had clinically disappeared and the scan returned to normal. The disappearance 5 months later of the antithyroid antibodies confirmed the cure. Catecholamines, stimulating the production of thyroid hormone and producing temporary ischemia of the gland, phenylpropanolamine, a sympathomimetic drug, may have caused hemorrhagic necrosis of the adenoma and its disappearance.
Sem Hop
PMID:[Evanescent toxic thyroid adenoma. Possible role of phenylpropanolamine]. 20 Oct 31

Sotalol is a new beta-adrenoceptor blocking drug without membrane stabilizing activity, without intrinsic sympathomimetic activity and with a low cardio-depressive effect. This beta-blocking agent has an half-life much longer than the other beta-blockers (T 1/2 from 10 to 13 hours). The antihypertensive effect and tolerance of 160 mg tablets of sotalol were studied in 35 hypertensive patients aged 18 to 60 years. The drug was administred once daily in the morning. Sotalol prescribed as the only antihypertensive drug lowered the blood pressure to normal values in 21 cases with a single daily of 1 to 3 tablets. In 8 patients a partial response was obtained (25 % reduction of the initial systolic and diatolic pressure). Six patients did not respond. The clinical and biological tolerances were good; Sotalol was only discontinued in three cases. Sotalol appears to be an effective and well tolerated antihypertensive agent, specially for the treatment of moderate and recent essential hypertension in young patients.
Sem Hop
PMID:[Treatment of hypertension with Sotalol (author's transl)]. 23 80