Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1323099 (sympathomimetic)
 2,957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four beta-blockers: atenolol 15 mg i.v., metoprolol 25 mg i.v., acebutolol 45 mg i.v. and labetalol 50 mg i.v. were administered to 106 patients suffering from hypertension and with normal or disturbed renal function. During an identical test protocol, measurements of clearance of inulin, of PAH, urine sodium and the fraction of sodium excreted were recorded one hour before and four or five hours after administration of the antihypertensive. Mean blood pressure and heart rate were also recorded. The three pure beta-blockers reduced inulin and PAH clearance and lowered urine sodium. These modifications were the same for all three drugs. Labetalol, which also possesses alpha-blocking properties, did not reduce renal function values or urine sodium. While a slight fall in blood pressure occurred with all the antihypertensives, heart rate was reduced only by the three pure beta-blockers. The action of the four drugs was very similar whatever the state of the subject's renal function. The study of the renal effects of the beta 1-selective atenolol and metoprolol, and acebutolol which has a higher intrinsic sympathomimetic activity does not demonstrate any significantly different renal action among these three drugs, but the effects of labetalol on renal function values and urine sodium are slighter. The renal action of the beta-blockers cannot be fully explained. Though the fall in the renal plasma flow and in the glomerular filtration rate can be related partly to the decrease in the cardiac output consequent to induced bradycardia, stimulation of renal alpha-receptors must be considered.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Comparative effects on renal function of 4 beta-blockers injected intravenously]. 613 63

In 8 ambulatory patients with stable essential hypertension (WHO grade I and II) the effects of a new beta-blocker with marked sympathomimetic activity on arterial blood pressure, creatinin clearance and renal plasma flow, as measured by total PAH clearance (constant infusion technique), were studied. In contrast to previous findings no significant reduction in creatinin clearance or renal blood flow was observed during a 3-5 weeks' observation period. The small reduction in calculated renal vascular resistance was not statistically significant. In addition to its postulated peripheral vasodilatory effect, bufuralol appears to interfere less than propranolol with renal hemodynamics and renal excretory function.
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PMID:[Bufuralol: do beta blockers reduce blood circulation in the kidneys?]. 613 56

In 20 healthy subjects hydro-saline depletion was achieved by a 4-day natriuretic treatment associated with hypo-saline diet. Dopamine (DA) was infused in subpressor dose (.1 microgram . kg-1 . min-1) during sustained hypotonic polyuria induced by 5% glucose infusion. Four 15-min clearance periods were performed. DA was infused during the 2nd and the 3rd period. The effective renal plasma flow (RPF) as well as the glomerular filtration rate (GFR) were calculated by PAH and creatinine clearances, respectively. In our experimental conditions DA produced: a) an increase in the abnormally isoosmotic sodium reabsorption as % of sodium distal load; b) a decrease in both sodium and osmolar clearance; c) an early increase in free water clearance. RPF and GFR decreased not significantly. The present results indicate that DA in hydro-saline depletion helps to preserve the extracellular fluid volume in minimizing the salt and water loss associated with hypotonic polyuria. These effects on sodium excretion may be related to sympathomimetic properties acquired by DA in this experimental condition.
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PMID:[Sympathomimetic component of dopamine renal action in water-saline depletion]. 744 90